(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Rosacea D012393 13 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Keloid D007627 12 associated lipids
Otitis Media D010033 12 associated lipids
Influenza, Human D007251 11 associated lipids
Hepatitis D006505 11 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Kelley MT et al. Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. 1969 J. Lipid Res. pmid:4305711
Sofer SS and Rilling HC Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. 1969 J. Lipid Res. pmid:4305712
Goad LJ and Goodwin TW Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. 1969 Eur. J. Biochem. pmid:5780485
Eppenberger U et al. [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. 1969 Eur. J. Biochem. pmid:5781271
Ikekawa N et al. Determination of morphine in urine by gas chromatography. 1969 Anal. Biochem. pmid:5781407
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
Tornabene TG et al. Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. 1969 J. Lipid Res. pmid:5785002
Porcellati G et al. Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. 1969 Lipids pmid:5785689
Boyd GS and Onajobi FD Control of cholesterol biosynthesis by a plasma apo-lipoprotein. 1969 Nature pmid:5789314
Miettinen TA Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. 1969 Life Sci. pmid:5801489
Foti L et al. Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. 1969 Life Sci. pmid:5804653
Yamamoto S and Bloch K On the enzymes catalysing the transformation of squalene to lanosterol. 1969 Biochem. J. pmid:5807185
Higgins MJ and Kekwick RG The role of malonyl-coenzyme A in isoprenoid biosynthesis. 1969 Biochem. J. pmid:5807201
Frayha GJ A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). 1968 Comp. Biochem. Physiol. pmid:5710286
Suzue G et al. Presence of squalene in Staphylococcus. 1968 Arch. Biochem. Biophys. pmid:5650319
Dempsey ME Inhibition of lipid biosynthesis. 1968 Ann. N. Y. Acad. Sci. pmid:4385358
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 J. Biol. Chem. pmid:4386511
Lofland HB et al. Atherosclerosis in Cebus monkeys. II. Arterial metabolism. 1968 Exp. Mol. Pathol. pmid:4969998
Cornforth JW Olefin alkylation in biosynthesis. 1968 Angew. Chem. Int. Ed. Engl. pmid:4976264
Sih CJ and Whitlock HW Biochemistry of steroids. 1968 Annu. Rev. Biochem. pmid:4875723
Rees HH et al. Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. 1968 Biochem. J. pmid:4297048
Shafai T and Lewin LM Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. 1968 Biochim. Biophys. Acta pmid:4298231
McLaren L et al. Dense-gas chromatography of nonvolatile substances of high molecular weight. 1968 Science pmid:5634909
Chorbanian AV Sterol synthesis in the human arterial intima. 1968 J. Clin. Invest. pmid:5637146
Clayton RB et al. The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide. 1968 J. Am. Chem. Soc. pmid:5638313
Rees HH et al. The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. 1968 Biochem. J. pmid:5639923
Rees HH et al. Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. 1968 Tetrahedron Lett. pmid:5640097
Aaronson S and Fulco L Effect of hypocholesteremic compounds on bacterial multiplication. 1968 J. Gen. Microbiol. pmid:5640227
Chesterton CJ Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. 1968 J. Biol. Chem. pmid:5646164
St Clair RW et al. Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. 1968 Exp. Mol. Pathol. pmid:5647248
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 Biochem. Biophys. Res. Commun. pmid:5653642
Dada OA et al. Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. 1968 Eur. J. Biochem. pmid:5653765
Wepierre J et al. Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. 1968 Eur. J. Pharmacol. pmid:5654669
Gianelly AA and Terner C Inhibition of cholesterol biosynthesis by dehydroepiandrosterone in lactating mammary gland. 1968 Endocrinology pmid:4177463
Locke DC Chromatographic study of solutions of hydrocarbons in acetonitrile. 1968 J. Chromatogr. pmid:5656425
Voogt PA Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. 1968 Arch. Int. Physiol. Biochim. pmid:4178041
Bighi C et al. Interpretation of gas chromatographic data. Hydrocarbons and aromatic compounds on Carbowax 400. 1968 J. Chromatogr. pmid:5658564
Giddings JC et al. High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. 1968 Science pmid:5675186
De Souza NJ and Nes WR Sterols: isolation from a blue-green alga. 1968 Science pmid:5677529
White HB et al. The occurrence of squalene in kipid of fowlpox virus. 1968 J. Biol. Chem. pmid:5684008
Godtfredsen WO et al. Biosynthesis of fusidic acid from squalene 2,3-oxide. 1968 J. Am. Chem. Soc. pmid:5688690
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091
Merdinger E et al. Composition of lipids in extracts of Pullularia pullulans. 1968 Can. J. Microbiol. pmid:5693067
Caspi E et al. The biosynthesis of tetrahymanol in vitro. 1968 Biochem. J. pmid:5696872
Ackman RG et al. Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. 1968 Nature pmid:5701840
Conner RL et al. Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. 1968 J. Protozool. pmid:5703082
Suzuki R Specific requirements of bile salts for absorption of cholesterol from the intestine. 1968 Keio J Med pmid:5715537
Mukherjee S and Bhose A Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. 1968 Biochim. Biophys. Acta pmid:5721032
Threlfall DR et al. Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. 1968 Biochem. J. pmid:5721452
Autrum H et al. [Squalene in the glandular secretion of mammals]. 1968 Naturwissenschaften pmid:5726004