(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Rosacea D012393 13 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Keloid D007627 12 associated lipids
Otitis Media D010033 12 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Influenza, Human D007251 11 associated lipids
Hepatitis D006505 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Crispino GA et al. Selective perhydroxylation of squalene: taming the arithmetic demon. 1993 Science pmid:8418495
Gloor M and Karenfeld A Effect of ultraviolet light therapy, given over a period of several weeks, on the amount and composition of the skin surface lipids. 1977 Dermatologica pmid:844642
Asnis DS et al. Shark oil pneumonia. An overlooked entity. 1993 Chest pmid:8449116
Balliano G et al. Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene. 1993 FEBS Lett. pmid:8462686
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
Prashad M Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. 1993 J. Med. Chem. pmid:8496942
Horie M et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. 1993 Biochim. Biophys. Acta pmid:8504141
Socaciu C et al. In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. 1995 C. R. Acad. Sci. III, Sci. Vie pmid:8521075
Kohasi O et al. Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D. 1977 Int. Arch. Allergy Appl. Immunol. pmid:852904
McKean ML and Nes WR Delayed conversion of squalene to sterols during development of Pinus pinea seeds. 1977 Lipids pmid:853880
Airaudi D et al. Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. 1995 Jul-Aug Mycoses pmid:8559196
Chan C et al. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8568810
Henk G and Heinz T [Hydrocarbon content in the fat of meat pigs after feeding "Fermosin"]. 1993 Arch Tierernahr pmid:8572916
Ott G et al. Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. 1995 Vaccine pmid:8578842
Astruc M et al. Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. 1977 Biochim. Biophys. Acta pmid:857899
Dracheva S et al. Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. 1996 FEBS Lett. pmid:8612754
Ito T et al. Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. 1996 Gastroenterology pmid:8613070
Yoshino S Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. 1996 Biomed. Pharmacother. pmid:8672728
Barth MM et al. Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. 1996 J. Med. Chem. pmid:8691425
Fan SR et al. Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. 1996 Mutat. Res. pmid:8692222
Yamada Y et al. Oxidation of linear terpenes and squalene variants by Arthrobacter sp. 1977 Appl. Environ. Microbiol. pmid:869527
Fogelman AM et al. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. 1977 Biochem. Biophys. Res. Commun. pmid:869944
Gylling H et al. The metabolism of cholestanol in primary biliary cirrhosis. 1996 J. Hepatol. pmid:8738731
Chan P et al. Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. 1996 J Clin Pharmacol pmid:8739021
Lakshmanan MR and Veech RL Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. 1977 J. Biol. Chem. pmid:873910
Keefer MC et al. Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. 1996 AIDS Res. Hum. Retroviruses pmid:8744579
Arthington-Skaggs BA et al. Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. 1996 FEBS Lett. pmid:8772195
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Higgins DA et al. MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. 1996 Vaccine pmid:8782343
Airaudi D et al. In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. 1996 Jan-Feb Mycoses pmid:8786759
Piretti MV et al. Simultaneous reversed-phase high-performance liquid chromatographic separation of non-polar isoprenoid lipids and their determination. 1995 J. Chromatogr. B, Biomed. Appl. pmid:8788146
Simon SA et al. The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. 1977 Biophys. J. pmid:880329
Gloor M and Kohler H A contribution to a new test method for dandruff-inhibiting and "keratolytic" action of drugs. 1977 Eur. J. Clin. Pharmacol. pmid:880976
Mark M et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. 1996 J. Lipid Res. pmid:8820110
Bonté F et al. Simarouba amara extract increases human skin keratinocyte differentiation. 1996 J Ethnopharmacol pmid:8844461
Ferguson JB and Bloch K Purification and properties of a soluble protein activator of rat liver squalene epoxidase. 1977 J. Biol. Chem. pmid:885856
Dogliotti M et al. Nutritional influences of pellagra on sebum composition. 1977 Br. J. Dermatol. pmid:889695
Kohashi O et al. Effect of oil composition on both adjuvant-induced arthritis and delayed hypersensitivity to purified protein derivative and peptidoglycans in various rat strains. 1977 Infect. Immun. pmid:892904
Fujie T et al. Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. 1996 Arch. Dermatol. Res. pmid:8931874
Grimes DS et al. Sunlight, cholesterol and coronary heart disease. 1996 QJM pmid:8935479
Traquina P et al. MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. 1996 J. Infect. Dis. pmid:8940205
Krisans SK Cell compartmentalization of cholesterol biosynthesis. 1996 Ann. N. Y. Acad. Sci. pmid:8993542
Stach D et al. Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. 1997 J. Med. Chem. pmid:9003518
Nikkilä K et al. Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. 1996 J. Lipid Res. pmid:9017519
Beytía ED and Porter JW Biochemistry of polyisoprenoid biosynthesis. 1976 Annu. Rev. Biochem. pmid:9026
Downing DT et al. The time course of lipid formation in human sebaceous glands. 1977 J. Invest. Dermatol. pmid:903669
Baum CL et al. Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. 1997 J. Biol. Chem. pmid:9045674
O'Hagan DT et al. Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. 1997 Mol Med Today pmid:9060004
Kushiro T et al. In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. 1997 Biol. Pharm. Bull. pmid:9084891
Eisele B et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. 1997 J. Lipid Res. pmid:9101437