(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Precancerous Conditions D011230 48 associated lipids
Parkinson Disease D010300 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
SOBEL H Squalene in sebum and sebum-like materials. 1949 J. Invest. Dermatol. pmid:15398762
HADORN H and JUNGKUNZ R [Further studies on squalene. 4]. 1950 Mitt Lebensmittelunters Hyg pmid:14806249
FLESCH P Hair loss from squalene. 1951 Proc. Soc. Exp. Biol. Med. pmid:14844354
HIGH EG and DAY HG Effects of different amounts of lutein, squalene, phytol and related substances on the utilization of carotene and vitamin A for storage and growth in the rat. 1951 J. Nutr. pmid:14851042
NICOLAIDES N and ROTHMAN S Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. 1952 J. Invest. Dermatol. pmid:13023010
DALE J Dehydrogenation of squalene with N-bromosuccinimide. 1952 Arch. Biochem. Biophys. pmid:13008464
WHEATLEY VR Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. 1953 Biochem. J. pmid:13115346
LANGDON RG and BLOCH K The biosynthesis of squalene. 1953 J. Biol. Chem. pmid:13034767
LANGDON RG and BLOCH K The utilization of squalene in the biosynthesis of cholesterol. 1953 J. Biol. Chem. pmid:13034768
CORNFORTH JW and POPJAK G Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. 1954 Biochem. J. pmid:13208629
SQUALENE, a precursor of cholesterol. 1954 Nutr. Rev. pmid:13166142
EIDINOFF ML et al. The biosynthesis of squalene from acetate in man. 1954 J. Clin. Invest. pmid:13143078
POPJAK G Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. 1954 Arch. Biochem. Biophys. pmid:13125576
SCHWENK E et al. Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. 1954 Arch. Biochem. Biophys. pmid:13139684
NICOLAIDES N and ROTHMAN S The site of sterol and squalene synthesis in the human skin. 1955 J. Invest. Dermatol. pmid:14354270
BOUGHTON B et al. Some observations of the nature, origin and possible function of the squalene and other hydrocarbons of human sebum. 1955 J. Invest. Dermatol. pmid:14354278
MACKENNA RM et al. Squalene and other hydrocarbons in human sebum. 1955 J. Physiol. (Lond.) pmid:14354699
DICKHART W The squalene contents of various oils. 1955 Am J Pharm Sci Support Public Health pmid:13275573
RABINOWITZ JL et al. Branched chain acids in the biosynthesis of squalene and cholesterol. 1955 Fed. Proc. pmid:13262139
DITURI F et al. Terpenoid intermediates in the biosynthesis of cholesterol. 1956 J. Biol. Chem. pmid:13345809