Goff PH et al. |
Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. |
2013 |
PLoS ONE |
pmid:24223176
|
Leszczynska A et al. |
Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. |
2009 |
PLoS ONE |
pmid:20041128
|
Lai RP et al. |
Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants. |
2012 |
PLoS ONE |
pmid:22509385
|
Marinaro M et al. |
A caprine herpesvirus 1 vaccine adjuvanted with MF59â„¢ protects against vaginal infection and interferes with the establishment of latency in goats. |
2012 |
PLoS ONE |
pmid:22511971
|
Oliaro-Bosso S et al. |
Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. |
2011 |
PLoS ONE |
pmid:21811565
|
Meyer K et al. |
A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infection. |
2011 |
PLoS ONE |
pmid:21887300
|
Bischoff AL et al. |
Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. |
2013 |
PLoS ONE |
pmid:23637733
|
Puleston R et al. |
Multi-centre observational study of transplacental transmission of influenza antibodies following vaccination with AS03(A)-adjuvanted H1N1 2009 vaccine. |
2013 |
PLoS ONE |
pmid:23372640
|
Takami T et al. |
A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. |
2012 |
PLoS ONE |
pmid:23145048
|
Henryk T et al. |
[The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. |
2005 |
Pol. Merkur. Lekarski |
pmid:15997638
|
Lewkowicz N et al. |
[Biological action and clinical application of shark liver oil]. |
2006 |
Pol. Merkur. Lekarski |
pmid:16875171
|
Sliwowski J |
[Mechanisms of squalene cyclization to tetra- and pentacyclic triterpenes (author's transl)]. |
1974 |
Postepy Biochem. |
pmid:4849151
|
Wojciechowski ZA |
[Protein activators of the biosynthesis and metabolism of cholesterol]. |
1986 |
Postepy Biochem. |
pmid:3550764
|
JACHYMCZYK W |
[Biosynthesis of triterpenoid compounds]. |
1963 |
Postepy Biochem. |
pmid:13957182
|
|
Influenza vaccine with squalene adjuvant: new preparation. No better than available products. |
2004 |
Prescrire Int |
pmid:15599987
|
Volkov GL et al. |
[In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. |
1976 Mar-Apr |
Prikl. Biokhim. Mikrobiol. |
pmid:1005362
|
Anisimov MM et al. |
[Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. |
1978 Jul-Aug |
Prikl. Biokhim. Mikrobiol. |
pmid:724665
|
Ellebedy AH et al. |
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21270336
|
Liu GC et al. |
Measurement of cholesterol synthesis in man by isotope kinetics of squalene. |
1975 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:1060141
|
Ritter MC and Dempsey ME |
Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. |
1973 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:4509660
|
Maksimenko A et al. |
A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. |
2014 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:24385587
|
Galli G et al. |
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. |
2009 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19237568
|
Vono M et al. |
The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:24324152
|
Galli G et al. |
Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. |
2009 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19416838
|
Werthemann L and Johnson WS |
Application of the chloro ketal Claisen reaction to the total synthesis of squalene. |
1970 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:5274470
|
Werthemann L and Johnson WS |
Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. |
1970 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:5275377
|
Mosca F et al. |
Molecular and cellular signatures of human vaccine adjuvants. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18650390
|
Fisher JE et al. |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9874784
|
Giron MD et al. |
Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. |
1994 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:8022795
|
Stone KJ and Strominger JL |
Inhibition of sterol biosynthesis by bacitracin. |
1972 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:4338587
|
Niehaus TD et al. |
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21746901
|
Yamamoto S et al. |
Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. |
1969 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:5257956
|
Shibata N et al. |
Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11226224
|
Lin FY et al. |
Mechanism of action and inhibition of dehydrosqualene synthase. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21098670
|
Chang TY et al. |
Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. |
1977 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:265577
|
McNamara DJ et al. |
Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. |
1977 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:268653
|
Seubert A et al. |
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21690334
|
Babiychuk E et al. |
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18287026
|
Popják G et al. |
Effects of 2,3-iminosqualene on cultured cells. |
1987 |
Proc. R. Soc. Lond., B, Biol. Sci. |
pmid:2894034
|
Cornforth JW et al. |
Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. |
1966 |
Proc. R. Soc. Lond., B, Biol. Sci. |
pmid:4379289
|
Cornforth JW et al. |
Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. |
1966 |
Proc. R. Soc. Lond., B, Biol. Sci. |
pmid:4379291
|
Cornforth J |
Symmetry of squalene epoxidation in vivo. |
1977 |
Proc. R. Soc. Lond., B, Biol. Sci. |
pmid:22855
|
SHORB MS et al. |
EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. |
1965 |
Proc. Soc. Exp. Biol. Med. |
pmid:14277681
|
ALEXANDER GJ and ALEXANDER RB |
INHIBITION OF CHOLESTEROL SYNTHESIS IN VIVO BY A CONVULSANT, METRAZOL. |
1964 |
Proc. Soc. Exp. Biol. Med. |
pmid:14117448
|
BURGESS TL and WILSON JD |
Studies on hormonal regulation of squalene synthesis in preputial gland and skin of the rat. |
1963 |
Proc. Soc. Exp. Biol. Med. |
pmid:14016990
|
GAYLOR JL |
Anaerobic conversion of acetate to squalene by rat skin. |
1961 |
Proc. Soc. Exp. Biol. Med. |
pmid:13704081
|
Fiser RH et al. |
Effects of acute infection on cholesterogenesis in the rhesus monkey. |
1971 |
Proc. Soc. Exp. Biol. Med. |
pmid:4399094
|
PATTERSON JF |
Biosynthesis of squalene by rat preputial gland. |
1960 |
Proc. Soc. Exp. Biol. Med. |
pmid:13733368
|
Bazzano G and Bazzano GS |
Hypocholesterolemic effect of -ketoglutarate in the Mongolian gerbil. |
1972 |
Proc. Soc. Exp. Biol. Med. |
pmid:5033114
|
Beck FW and Whitehouse MW |
I. Drug sensitivity of rat adjuvant arthritis, induced with "adjuvants" containing no mineral oil components. |
1974 |
Proc. Soc. Exp. Biol. Med. |
pmid:4841187
|
FLESCH P |
Hair loss from squalene. |
1951 |
Proc. Soc. Exp. Biol. Med. |
pmid:14844354
|
Theiner M and Friedman L |
Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. |
1969 |
Proc. Soc. Exp. Biol. Med. |
pmid:4183040
|
Aaronson S |
Inhibition of yeast multiplication by hypocholesteremic compounds and its annulment by lipids. |
1971 |
Proc. Soc. Exp. Biol. Med. |
pmid:5540639
|
Mercer EI |
Inhibitors of sterol biosynthesis and their applications. |
1993 |
Prog. Lipid Res. |
pmid:8309949
|
Haines TH |
Do sterols reduce proton and sodium leaks through lipid bilayers? |
2001 |
Prog. Lipid Res. |
pmid:11412894
|
Buddhan S et al. |
Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats. |
2007 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:17574827
|
Szostak WB and Szostak-Wegierek D |
[Health properties of shark oil]. |
2006 |
Prz. Lek. |
pmid:17083160
|
Grimes DS et al. |
Sunlight, cholesterol and coronary heart disease. |
1996 |
QJM |
pmid:8935479
|
Limberti A et al. |
[Squalene-cholesterol ratio in the amniotic fluid and gestational age: changes in the threshold in relation to the preparation of the sample]. |
1986 |
Quad Sclavo Diagn |
pmid:3786665
|
Palamarchuk VI et al. |
[Radiation-induced changes in the content of squalene, lathosterol and cholesterol in rat blood proteins]. |
1991 May-Jun |
Radiobiologiia |
pmid:1887013
|
Palamarchuk VI |
[Characteristics of the radiation-induced changes in the content of sterols and squalene in the lymphoid system tissues and erythrocyte membranes of rats]. |
1990 May-Jun |
Radiobiologiia |
pmid:2371389
|
Novoselova EG and KolomiÄtseva IK |
[Early radiation impairments of the metabolism of cholesterol, squalene and ubiquinone in rat liver]. |
1976 Jul-Aug |
Radiobiologiia |
pmid:996254
|
Zambonin CG et al. |
Laser desorption/ionization time-of-flight mass spectrometry of squalene in oil samples. |
2006 |
Rapid Commun. Mass Spectrom. |
pmid:16345138
|
Camin F et al. |
Stable isotope ratios of carbon and hydrogen to distinguish olive oil from shark squalene-squalane. |
2010 |
Rapid Commun. Mass Spectrom. |
pmid:20499327
|
Naziri E and Tsimidou MZ |
Formulated squalene for food related applications. |
2013 |
Recent Pat Food Nutr Agric |
pmid:23270393
|
Richter E and Schäfer SG |
The effect of squalane on the absorption of dietary cholesterol by the rat. |
1982 |
Res Exp Med (Berl) |
pmid:7100640
|
Dillard CJ et al. |
Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. |
1982 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:7122999
|
Allison AC and Byars NE |
Syntex adjuvant formulation. |
1992 |
Res. Immunol. |
pmid:1439132
|
VILLALBA GOMEZ GM |
[Squalene index]. |
1956 May-Aug |
Rev Sanid Asist Soc |
pmid:13379961
|
Linares A et al. |
Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. |
1984 |
Rev. Esp. Fisiol. |
pmid:6531508
|
Tilvis RS et al. |
Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. |
1978 |
Scand. J. Clin. Lab. Invest. |
pmid:628820
|
Koivisto PV and Miettinen TA |
Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. |
1988 |
Scand. J. Clin. Lab. Invest. |
pmid:3217753
|
Miettinen TA and Tilvis R |
Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. |
1981 |
Scand. J. Clin. Lab. Invest. |
pmid:7313530
|
Strandberg TE et al. |
Squalene and sterol synthesis in isolated small-intestinal cells of the rat. |
1981 |
Scand. J. Gastroenterol. |
pmid:7323711
|
Tsai TF et al. |
Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. |
2011 |
Scand. J. Infect. Dis. |
pmid:21534891
|
Del Giudice G et al. |
Seasonal influenza vaccine provides priming for A/H1N1 immunization. |
2009 |
Sci Transl Med |
pmid:20371459
|
Khurana S et al. |
Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. |
2010 |
Sci Transl Med |
pmid:20371470
|
Pollard AJ and Hill AV |
Antibody repertoire: embracing diversity. |
2011 |
Sci Transl Med |
pmid:21795586
|
Khurana S et al. |
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. |
2011 |
Sci Transl Med |
pmid:21632986
|
Cornforth JW |
Asymmetry and enzyme action. |
1976 |
Science |
pmid:935862
|
Edmond J et al. |
Mevalonate metabolism: role of kidneys. |
1976 |
Science |
pmid:935865
|
Blumer M |
Hydrocarbons in digestive tract and liver of a basking shark. |
1967 |
Science |
pmid:5609822
|
Wendt KU et al. |
Structure and function of a squalene cyclase. |
1997 |
Science |
pmid:9295270
|
Graebe JE |
Isoprenoid biosynthesis in a cell-free system from pea shoots. |
1967 |
Science |
pmid:4381746
|
Crispino GA et al. |
Selective perhydroxylation of squalene: taming the arithmetic demon. |
1993 |
Science |
pmid:8418495
|
Hayaishi O and Nozaki M |
Nature and mechanisms of oxygenases. |
1969 |
Science |
pmid:4304952
|
McLaren L et al. |
Dense-gas chromatography of nonvolatile substances of high molecular weight. |
1968 |
Science |
pmid:5634909
|
Giddings JC et al. |
High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. |
1968 |
Science |
pmid:5675186
|
De Souza NJ and Nes WR |
Sterols: isolation from a blue-green alga. |
1968 |
Science |
pmid:5677529
|
Maugh TH |
Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. |
1982 |
Science |
pmid:7146911
|
Sherman DR et al. |
Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. |
1992 |
Science |
pmid:1470914
|
Wohlrab J et al. |
Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine. |
2010 |
Skin Pharmacol Physiol |
pmid:20523109
|
Ekanayake-Mudiyanselage S et al. |
Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids. |
2005 Jan-Feb |
Skin Pharmacol Physiol |
pmid:15608499
|
Zouboulis CC et al. |
Culture of human sebocytes and markers of sebocytic differentiation in vitro. |
1991 |
Skin Pharmacol. |
pmid:1715175
|
Chiba K et al. |
Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. |
2003 Jul-Aug |
Skin Pharmacol. Appl. Skin Physiol. |
pmid:12784064
|
Couvreur P et al. |
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. |
2008 |
Small |
pmid:18247384
|
Dean PD |
The cyclases of triterpene and sterol biosynthesis. |
1971 |
Steroidologia |
pmid:5004310
|
Cattel L et al. |
Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase. |
1989 Mar-May |
Steroids |
pmid:2678608
|
Seo S et al. |
Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. |
1993 |
Steroids |
pmid:8484187
|
Lewis D et al. |
Enzyme inhibition during the conversion of squalene to cholesterol. |
1995 |
Steroids |
pmid:7482633
|