(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Fatigue D005221 10 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Fibrosarcoma D005354 8 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Chronic Disease D002908 7 associated lipids
Alopecia Areata D000506 6 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Parasitemia D018512 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Dracheva S et al. Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. 1996 FEBS Lett. pmid:8612754
Astruc M et al. Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. 1977 Biochim. Biophys. Acta pmid:857899
Ott G et al. Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. 1995 Vaccine pmid:8578842
Henk G and Heinz T [Hydrocarbon content in the fat of meat pigs after feeding "Fermosin"]. 1993 Arch Tierernahr pmid:8572916
Chan C et al. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8568810
Airaudi D et al. Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. 1995 Jul-Aug Mycoses pmid:8559196
McKean ML and Nes WR Delayed conversion of squalene to sterols during development of Pinus pinea seeds. 1977 Lipids pmid:853880
Kohasi O et al. Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D. 1977 Int. Arch. Allergy Appl. Immunol. pmid:852904
Socaciu C et al. In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. 1995 C. R. Acad. Sci. III, Sci. Vie pmid:8521075
Horie M et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. 1993 Biochim. Biophys. Acta pmid:8504141
Prashad M Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. 1993 J. Med. Chem. pmid:8496942
Seo S et al. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes. 1993 Steroids pmid:8484187
Balliano G et al. Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene. 1993 FEBS Lett. pmid:8462686
Asnis DS et al. Shark oil pneumonia. An overlooked entity. 1993 Chest pmid:8449116
Gloor M and Karenfeld A Effect of ultraviolet light therapy, given over a period of several weeks, on the amount and composition of the skin surface lipids. 1977 Dermatologica pmid:844642
Crispino GA et al. Selective perhydroxylation of squalene: taming the arithmetic demon. 1993 Science pmid:8418495
Kawakami T et al. Squalane as a possible carrier of bone morphogenetic protein. 1993 Biomaterials pmid:8399948
Lohner K et al. Squalene promotes the formation of non-bilayer structures in phospholipid model membranes. 1993 Biochim. Biophys. Acta pmid:8399307
Storm HM et al. Radioprotection of mice by dietary squalene. 1993 Lipids pmid:8355581
Miettinen TA and Vanhanen H Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. 1994 Am. J. Clin. Nutr. pmid:8310985
Mercer EI Inhibitors of sterol biosynthesis and their applications. 1993 Prog. Lipid Res. pmid:8309949
Phleger CF et al. Membrane biosynthesis in swimbladders of deep sea fishes Coryphaenoides acrolepis and Antimora rostrata. 1977 Comp. Biochem. Physiol., B pmid:830467
Florin-Christensen M et al. Occurrence of specific sterols in Pneumocystis carinii. 1994 Biochem. Biophys. Res. Commun. pmid:8292026
Ernst J et al. The crystal structure of squalene. 1976 Angew. Chem. Int. Ed. Engl. pmid:827944
Balliano G et al. 3-Carboxy-4-nitrophenyl-dithio-1,1',2-trisnorsqualene: a site-directed inactivator of yeast oxidosqualene cyclase. 1993 Lipids pmid:8246689
Vanhanen HT et al. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. 1993 J. Lipid Res. pmid:8228636
Ciosek CP et al. Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo. 1993 J. Biol. Chem. pmid:8227045
Beck FW and Whitehouse MW Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. 1976 Agents Actions pmid:822699
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Ohkawa S et al. Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. 1994 AIDS Res. Hum. Retroviruses pmid:8179961
Inoue H et al. Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. 1994 Biochem. Biophys. Res. Commun. pmid:8179579
Byars NE et al. Vaccinating guinea pigs with recombinant glycoprotein D of herpes simplex virus in an efficacious adjuvant formulation elicits protection against vaginal infection. 1994 Vaccine pmid:8165851
Mookhtiar KA et al. Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. 1994 J. Biol. Chem. pmid:8157649
Ren Z and Gould MN Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. 1994 Cancer Lett. pmid:8149348
Abe I [Bioorganic chemistry of squalene cyclase]. 1994 Tanpakushitsu Kakusan Koso pmid:8090933
Hilgers LA et al. A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs. 1994 Vaccine pmid:8085386
Hilgers LA et al. A novel non-mineral oil-based adjuvant. I. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in laboratory animals. 1994 Vaccine pmid:8085385
Sunthornandh P and Ratanabanangkoon K A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. 1994 Toxicon pmid:8079368
Domnas A et al. Squalene metabolism in two species of Lagenidium. 1994 Can. J. Microbiol. pmid:8076247
Tulliez J et al. [The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism]. 1975 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:807414
Gylling H and Miettinen TA Postabsorptive metabolism of dietary squalene. 1994 Atherosclerosis pmid:8060377
Dollis D and Schuber F Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. 1994 Biochem. Pharmacol. pmid:8043030
Giron MD et al. Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8022795
Pogliani L et al. An NMR and molecular mechanics study of squalene and squalene derivatives. 1994 Chem. Phys. Lipids pmid:8013054
Ortiz de Montellano PR and Boparai AS The squalene synthetase active site. Catalytic acceptance of 7- and 11- demethylfarnesyl pyrophosphates. 1976 Biochem. Biophys. Res. Commun. pmid:800341
Wieland B et al. Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus. 1994 J. Bacteriol. pmid:8002598
Hoffman SL et al. Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. 1994 Am. J. Trop. Med. Hyg. pmid:7985753
Kahn JO et al. Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers. 1994 J. Infect. Dis. pmid:7963729
Valensi JP et al. Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. 1994 J. Immunol. pmid:7930610
Coates RM Biogenetic-type rearrangements of terpenes. 1976 Fortschr Chem Org Naturst pmid:791779