| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fatigue | D005221 | 10 associated lipids |
| Photosensitivity Disorders | D010787 | 8 associated lipids |
| Fibrosarcoma | D005354 | 8 associated lipids |
| Chondrodysplasia Punctata | D002806 | 8 associated lipids |
| Chronic Disease | D002908 | 7 associated lipids |
| Alopecia Areata | D000506 | 6 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Parasitemia | D018512 | 5 associated lipids |
| Tinea Versicolor | D014010 | 5 associated lipids |
| Keratitis, Herpetic | D016849 | 5 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bhilwade HN et al. | Squalene as novel food factor. | 2010 | Curr Pharm Biotechnol | pmid:20874681 |
| Iannitti T and Palmieri B | An update on the therapeutic role of alkylglycerols. | 2010 | Mar Drugs | pmid:20948908 |
| Fragapane E et al. | A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly. | 2010 | Clin. Vaccine Immunol. | pmid:20810680 |
| Esposito S et al. | Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major. | 2010 | Vaccine | pmid:20888873 |
| Khurana S et al. | Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. | 2010 | Sci Transl Med | pmid:20371470 |
| Lippi G et al. | Vaccination, squalene and anti-squalene antibodies: facts or fiction? | 2010 | Eur. J. Intern. Med. | pmid:20206873 |
| Barnett SW et al. | Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant. | 2010 | J. Virol. | pmid:20392857 |
| Caron J et al. | Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20363623 |
| Xiong Z et al. | A short total synthesis of (+)-omaezakianol via an epoxide-initiated cationic cascade reaction. | 2010 | Org. Lett. | pmid:20218639 |
| Durando P et al. | MF59-adjuvanted vaccine: a safe and useful tool to enhance and broaden protection against seasonal influenza viruses in subjects at risk. | 2010 | Expert Opin Biol Ther | pmid:20218923 |
| Taramino S et al. | Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. | 2010 | Biochim. Biophys. Acta | pmid:19879375 |
| van Himbergen TM et al. | Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19834104 |
| Keitel W et al. | Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. | 2010 | Vaccine | pmid:19835829 |
| Brunner R et al. | The ABC of clinical and experimental adjuvants--a brief overview. | 2010 | Immunol. Lett. | pmid:19895847 |
| Eroglu E and Melis A | Extracellular terpenoid hydrocarbon extraction and quantitation from the green microalgae Botryococcus braunii var. Showa. | 2010 | Bioresour. Technol. | pmid:20005092 |
| Kalvodova L | Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20018176 |
| Xiao L et al. | The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. | 2010 | Biomaterials | pmid:20488530 |
| Carmona A et al. | Immunogenicity and safety of AS03-adjuvanted 2009 influenza A H1N1 vaccine in children 6-35 months. | 2010 | Vaccine | pmid:20600478 |
| Caligiani A et al. | Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction. | 2010 | Plant Foods Hum Nutr | pmid:20607413 |
| Zhao RY et al. | Cloning and characterization of squalene synthase gene from Fusarium fujikuroi (Saw.) Wr. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20585832 |
| Yasuda Y et al. | Comparison of half and full doses of an MF59-adjuvanted cell culture-derived A/H1N1v vaccine in Japanese children. | 2010 | Adv Ther | pmid:20586002 |
| Frey SE et al. | Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. | 2010 | Vaccine | pmid:20619382 |
| Dosio F et al. | Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation. | 2010 | Bioconjug. Chem. | pmid:20597546 |
| Sarpietro MG et al. | Interaction of acyclovir and its squalenoyl-acyclovir prodrug with DMPC in monolayers at the air/water interface. | 2010 | Int J Pharm | pmid:20635474 |
| Wohlrab J et al. | Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine. | 2010 | Skin Pharmacol Physiol | pmid:20523109 |
| Koohang A et al. | Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. | 2010 | J. Org. Chem. | pmid:20545375 |
| Camin F et al. | Stable isotope ratios of carbon and hydrogen to distinguish olive oil from shark squalene-squalane. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20499327 |
| Mantzouridou F and Tsimidou MZ | Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. | 2010 | FEMS Yeast Res. | pmid:20550581 |
| Van Damme P et al. | Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. | 2010 | BMC Infect. Dis. | pmid:20504306 |
| Waddington CS et al. | Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. | 2010 | BMJ | pmid:20508026 |
| Beck F et al. | Queries about vaccines containing squalene. | 2010 | Immunol. Cell Biol. | pmid:20157330 |
| Gerpe A et al. | Naftifine-analogues as anti-Trypanosoma cruzi agents. | 2010 | Eur J Med Chem | pmid:20163894 |
| Warleta F et al. | Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. | 2010 | Food Chem. Toxicol. | pmid:20138105 |
| Sugihara N et al. | Novel fractionation method for squalene and phytosterols contained in the deodorization distillate of rice bran oil. | 2010 | J Oleo Sci | pmid:20103978 |
| Chen CC et al. | Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. | 2010 | Eur J Pharm Biopharm | pmid:20060469 |
| Spanova M et al. | Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiae. | 2010 | J. Biol. Chem. | pmid:20032462 |
| Tsai T et al. | Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. | 2010 | Vaccine | pmid:19969117 |
| Narayan BH et al. | Modulation of doxorubicin-induced genotoxicity by squalene in Balb/c mice. | 2010 | Food Funct | pmid:21776469 |
| Bildstein L et al. | Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway. | 2010 | J Control Release | pmid:20691740 |
| Weiss TL et al. | Raman spectroscopy analysis of botryococcene hydrocarbons from the green microalga Botryococcus braunii. | 2010 | J. Biol. Chem. | pmid:20705610 |
| Kato S et al. | Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics. | 2010 | J Nanosci Nanotechnol | pmid:21137794 |
| Lin FY et al. | Mechanism of action and inhibition of dehydrosqualene synthase. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21098670 |
| Ali NA et al. | Essential oil composition of leaves of Stachys yemenensis obtained by supercritical COâ‚‚. | 2010 | Nat. Prod. Res. | pmid:21104527 |
| Walker WT and Faust SN | Monovalent inactivated split-virion AS03-adjuvanted pandemic influenza A (H1N1) vaccine. | 2010 | Expert Rev Vaccines | pmid:21105775 |
| El Sahly H | MF59™ as a vaccine adjuvant: a review of safety and immunogenicity. | 2010 | Expert Rev Vaccines | pmid:20923265 |
| Waddington C et al. | Open-label, randomised, parallel-group, multicentre study to evaluate the safety, tolerability and immunogenicity of an AS03(B)/oil-in-water emulsion-adjuvanted (AS03(B)) split-virion versus non-adjuvanted whole-virion H1N1 influenza vaccine in UK children 6 months to 12 years of age. | 2010 | Health Technol Assess | pmid:20923610 |
| Reddy LH et al. | Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor. | 2009 Sep-Oct | Mol. Pharm. | pmid:19634915 |
| Huang MH et al. | Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine. | 2009 May-Jun | Microbes Infect. | pmid:19344782 |
| Kopena R et al. | Lipophilic compounds from the femoral gland secretions of male Hungarian green lizards, Lacerta viridis. | 2009 May-Jun | Z. Naturforsch., C, J. Biosci. | pmid:19678551 |
| Seiki S and Frishman WH | Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. | 2009 Mar-Apr | Cardiol Rev | pmid:19367148 |
| Huang ZR et al. | Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. | 2009 | Molecules | pmid:19169201 |
| Banzhoff A et al. | MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. | 2009 | PLoS ONE | pmid:19197383 |
| Tritto E et al. | Mechanism of action of licensed vaccine adjuvants. | 2009 | Vaccine | pmid:19200813 |
| Ansaldi F et al. | Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection. | 2009 | Vaccine | pmid:19200846 |
| Galli G et al. | Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19237568 |
| Lambrecht BN et al. | Mechanism of action of clinically approved adjuvants. | 2009 | Curr. Opin. Immunol. | pmid:19246182 |
| Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-omaezakianol. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19248063 |
| Burke B et al. | Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits. | 2009 | Virology | pmid:19249806 |
| Baudner BC et al. | MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020). | 2009 | Pharm. Res. | pmid:19255727 |
| Radak BK et al. | Modeling reactive scattering of F(2P) at a liquid squalane interface: a hybrid QM/MM molecular dynamics study. | 2009 | J Phys Chem A | pmid:19323516 |
| Kato S et al. | Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371265 |
| Campagnac E et al. | Fenpropimorph slows down the sterol pathway and the development of the arbuscular mycorrhizal fungus Glomus intraradices. | 2009 | Mycorrhiza | pmid:19340463 |
| Cheng J and Hoshino T | Cyclization cascade of the C33-bisnorheptaprenoid catalyzed by recombinant squalene cyclase. | 2009 | Org. Biomol. Chem. | pmid:19343258 |
| Seelert H et al. | From protons to OXPHOS supercomplexes and Alzheimer's disease: structure-dynamics-function relationships of energy-transducing membranes. | 2009 | Biochim. Biophys. Acta | pmid:19281792 |
| Uchida H et al. | Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. | 2009 | Planta | pmid:19283408 |
| Sarpietro MG et al. | Conjugation of squalene to acyclovir improves the affinity for biomembrane models. | 2009 | Int J Pharm | pmid:19686827 |
| Pellegrini M et al. | MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database. | 2009 | Vaccine | pmid:19751689 |
| Ryu A et al. | Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. | 2009 | Biol. Pharm. Bull. | pmid:19721223 |
| Clark TW et al. | Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine. | 2009 | N. Engl. J. Med. | pmid:19745215 |
| Ghimire GP et al. | Improved squalene production via modulation of the methylerythritol 4-phosphate pathway and heterologous expression of genes from Streptomyces peucetius ATCC 27952 in Escherichia coli. | 2009 | Appl. Environ. Microbiol. | pmid:19767465 |
| Shabtay A et al. | The potential of Pleurotus-treated olive mill solid waste as cattle feed. | 2009 | Bioresour. Technol. | pmid:19683915 |
| Pedroso N et al. | Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. | 2009 | Free Radic. Biol. Med. | pmid:19027845 |
| Laitinen K et al. | Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. | 2009 | Br. J. Nutr. | pmid:19017423 |
| Godio RP and MartÃn JF | Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid. | 2009 | Fungal Genet. Biol. | pmid:19130892 |
| Wertz PW | Human synthetic sebum formulation and stability under conditions of use and storage. | 2009 | Int J Cosmet Sci | pmid:19134124 |
| Matyas GR et al. | Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. | 2009 | Biochim. Biophys. Acta | pmid:19100711 |
| Ghimire GP et al. | Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization. | 2009 | Biotechnol. Lett. | pmid:19116691 |
| Alam MM et al. | Phase behavior, formation, and rheology of cubic phase and related gel emulsion in Tween 80/water/oil systems. | 2009 | J Oleo Sci | pmid:19491531 |
| Herchi W et al. | Characterization and quantification of the aliphatic hydrocarbon fraction during linseed development ( Linum usitatissimum L.). | 2009 | J. Agric. Food Chem. | pmid:19492811 |
| Cho S et al. | High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects. | 2009 | Clin. Exp. Dermatol. | pmid:19522983 |
| Petrick L and Dubowski Y | Heterogeneous oxidation of squalene film by ozone under various indoor conditions. | 2009 | Indoor Air | pmid:19500173 |
| Tokuhiro K et al. | Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae. | 2009 | Appl. Environ. Microbiol. | pmid:19592534 |
| Pass RF | Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant. | 2009 | J. Clin. Virol. | pmid:19647480 |
| Forrest HL et al. | Single- and multiple-clade influenza A H5N1 vaccines induce cross protection in ferrets. | 2009 | Vaccine | pmid:19406182 |
| López P and MartÃn J | Potential chemosignals associated with male identity in the amphisbaenian Blanus cinereus. | 2009 | Chem. Senses | pmid:19406874 |
| Al-Edresi S and Baie S | Formulation and stability of whitening VCO-in-water nano-cream. | 2009 | Int J Pharm | pmid:19429303 |
| Camilloni B et al. | Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages. | 2009 | Vaccine | pmid:19410623 |
| Galli G et al. | Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19416838 |
| Phillips CJ et al. | Antibodies to squalene in US Navy Persian Gulf War veterans with chronic multisymptom illness. | 2009 | Vaccine | pmid:19379786 |
| Del Giudice G et al. | Seasonal influenza vaccine provides priming for A/H1N1 immunization. | 2009 | Sci Transl Med | pmid:20371459 |
| Couvreur P | ["Squalenoylation": a new approach to the design of anticancer and antiviral nanomedicines]. | 2009 | Bull. Acad. Natl. Med. | pmid:19883017 |
| Tong R et al. | Stereo- and regioselective synthesis of squalene tetraepoxide. | 2009 | J. Org. Chem. | pmid:19827774 |
| Vesikari T et al. | MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination. | 2009 | Vaccine | pmid:19840662 |
| Kim ES et al. | Squalene-induced exogenous lipoid pneumonia in an infant. | 2009 | Pediatr Int | pmid:19799746 |
| Laursen AB | [Dangerous adjuvant in swine influenza vaccine]. | 2009 | Ugeskr. Laeg. | pmid:19866499 |
| Reddy LH and Couvreur P | Squalene: A natural triterpene for use in disease management and therapy. | 2009 | Adv. Drug Deliv. Rev. | pmid:19804806 |
| Gerpe A et al. | 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. | 2009 | Bioorg. Med. Chem. | pmid:19811923 |
| Bildstein L et al. | Freeze-drying of squalenoylated nucleoside analogue nanoparticles. | 2009 | Int J Pharm | pmid:19782881 |
| Fox CB | Squalene emulsions for parenteral vaccine and drug delivery. | 2009 | Molecules | pmid:19783926 |
| Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |