Van Leusden H and Villee CA |
The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. |
1965 |
Steroids |
pmid:5857495
|
Cattel L et al. |
Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase. |
1989 Mar-May |
Steroids |
pmid:2678608
|
Lewis D et al. |
Enzyme inhibition during the conversion of squalene to cholesterol. |
1995 |
Steroids |
pmid:7482633
|
Dennick RG |
The intracellular organisation of cholesterol biosynthesis. A review. |
1972 |
Steroids Lipids Res |
pmid:4572325
|
Abe I |
[Bioorganic chemistry of squalene cyclase]. |
1994 |
Tanpakushitsu Kakusan Koso |
pmid:8090933
|
Yamamoto S |
[Oxidative cyclization of squalene. Biosynthesis of sterols]. |
1970 |
Tanpakushitsu Kakusan Koso |
pmid:4912088
|
Corey EJ and Yamamoto H |
Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. |
1970 |
Tetrahedron Lett. |
pmid:5447652
|
Rees HH et al. |
Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. |
1968 |
Tetrahedron Lett. |
pmid:5640097
|
Montana M et al. |
Safety review: squalene and thimerosal in vaccines. |
2010 Nov-Dec |
Therapie |
pmid:21176760
|
Dorea JG |
Safety of thimerosal in vaccines: for whom and how many doses? |
2011 Mar-Apr |
Therapie |
pmid:23189333
|
Achiraman S et al. |
Increased squalene concentrations in the clitoral gland during the estrous cycle in rats: an estrus-indicating scent mark? |
2011 |
Theriogenology |
pmid:21924481
|
Alghisi F et al. |
Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis. |
2011 |
Thorax |
pmid:21228426
|
Miettinen TA |
Hyperlipoproteinemia--relation to platelet lipids, platelet function and tendency to thrombosis. |
1974 |
Thromb. Res. |
pmid:4367389
|
Ali HM et al. |
Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. |
2014 |
Thyroid |
pmid:23885719
|
Chida N and Okamura T |
Increased cholesterol-biosynthesis in familial hypercholesterolemia. |
1971 |
Tohoku J. Exp. Med. |
pmid:5140375
|
Torinuki W et al. |
Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. |
1982 |
Tohoku J. Exp. Med. |
pmid:7101278
|
Hayakawa K and Matsuo I |
Effects of PUVA therapy on skin surface lipids: skin surface lipid peroxidation in psoriasis vulgaris and its biological significance. |
1986 |
Tokai J. Exp. Clin. Med. |
pmid:3672560
|
Yockel S and Schatz GC |
Dynamic QM/MM: a hybrid approach to simulating gas-liquid interactions. |
2012 |
Top Curr Chem |
pmid:21506003
|
Uchino T et al. |
Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. |
2004 |
Toxicol In Vitro |
pmid:15046771
|
Flint OP et al. |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. |
1997 |
Toxicol. Appl. Pharmacol. |
pmid:9221828
|
Kuroda Y et al. |
Distinctive patterns of autoimmune response induced by different types of mineral oil. |
2004 |
Toxicol. Sci. |
pmid:14718649
|
Sunthornandh P and Ratanabanangkoon K |
A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. |
1994 |
Toxicon |
pmid:8079368
|
Johnson WS |
Nonenzymic biogenetic-like olefinic cyclizations. |
1967 |
Trans N Y Acad Sci |
pmid:5237390
|
Gylling H et al. |
Cholesterol synthesis prevails over absorption in metabolic syndrome. |
2007 |
Transl Res |
pmid:17543849
|
Siirtola A et al. |
Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. |
2006 |
Transplantation |
pmid:16477216
|
Moebius FF et al. |
Genetic defects in postsqualene cholesterol biosynthesis. |
2000 |
Trends Endocrinol. Metab. |
pmid:10707051
|
Laursen AB |
[Dangerous adjuvant in swine influenza vaccine]. |
2009 |
Ugeskr. Laeg. |
pmid:19866499
|
Bruun Laursen A |
[Catastrophic consequences of Pandemrix swine flu vaccine containing squalene]. |
2013 |
Ugeskr. Laeg. |
pmid:23833781
|
Mølbak K |
[Squalene unlikely sinner]. |
2013 |
Ugeskr. Laeg. |
pmid:23833782
|
Ihara T |
[Evaluation of alum-adjuvanted whole virus influenza vaccine and future aspects of influenza A (H1N1) 2009 vaccine]. |
2010 |
Uirusu |
pmid:20848866
|
Vendt VP |
[Studies in the field of chemistry, biochemistry and photobiochemistry of sterols]. |
1975 Sep-Oct |
Ukr Biokhim Zh |
pmid:1105921
|
Sanina OL and Datsenko ZM |
[Sterol composition of sarcolemma in normal rabbits and in experimental muscular dystrophy]. |
1975 Nov-Dec |
Ukr Biokhim Zh |
pmid:1202710
|
PerederiÄ OF and Morozova RP |
[Squalene and sterols of rat stomach tissue and the effect of acetylsalicylic acid on their content]. |
1978 Nov-Dec |
Ukr. Biokhim. Zh. |
pmid:749299
|
Morozova RP et al. |
[Separation of lipid extract from animal blood and tissues and isolation of squalene and sterols from it]. |
1982 Jul-Aug |
Ukr. Biokhim. Zh. |
pmid:7135500
|
Dediukhina EG and Eroshin VK |
[Hydrocarbon biosynthesis by microorganisms]. |
1973 Nov-Dec |
Usp Sovrem Biol |
pmid:4593530
|
Morel S et al. |
Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity. |
2011 |
Vaccine |
pmid:21256188
|
Decaro N et al. |
Immunogenicity and protective efficacy in dogs of an MF59â„¢-adjuvanted vaccine against recombinant canine/porcine coronavirus. |
2011 |
Vaccine |
pmid:21272607
|
de Roux A et al. |
Impact of corticosteroids on the immune response to a MF59-adjuvanted influenza vaccine in elderly COPD-patients. |
2006 |
Vaccine |
pmid:16288937
|
Singh M et al. |
A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens. |
2006 |
Vaccine |
pmid:16300864
|
Puig-Barberà J et al. |
Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. |
2004 |
Vaccine |
pmid:15530669
|
Tritto E et al. |
Mechanism of action of licensed vaccine adjuvants. |
2009 |
Vaccine |
pmid:19200813
|
Ansaldi F et al. |
Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection. |
2009 |
Vaccine |
pmid:19200846
|
Del Giudice G et al. |
An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. |
2006 |
Vaccine |
pmid:16464520
|
Cataldo DM and Van Nest G |
The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. |
1997 |
Vaccine |
pmid:9364672
|
Barnett SW et al. |
Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. |
1997 |
Vaccine |
pmid:9234536
|
Romera SA et al. |
Adjuvant effects of sulfolipo-cyclodextrin in a squalane-in-water and water-in-mineral oil emulsions for BHV-1 vaccines in cattle. |
2000 |
Vaccine |
pmid:10924795
|
Schultze V et al. |
Safety of MF59 adjuvant. |
2008 |
Vaccine |
pmid:18462843
|
Boyce TG et al. |
Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adults. |
2000 |
Vaccine |
pmid:10930676
|
O'Hagan DT et al. |
Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1. |
2000 |
Vaccine |
pmid:10699327
|
Keitel W et al. |
Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. |
2010 |
Vaccine |
pmid:19835829
|
Vesikari T et al. |
MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination. |
2009 |
Vaccine |
pmid:19840662
|
Hilgers LA et al. |
A novel non-mineral oil-based adjuvant. I. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in laboratory animals. |
1994 |
Vaccine |
pmid:8085385
|
Hilgers LA et al. |
A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs. |
1994 |
Vaccine |
pmid:8085386
|
Byars NE et al. |
Vaccinating guinea pigs with recombinant glycoprotein D of herpes simplex virus in an efficacious adjuvant formulation elicits protection against vaginal infection. |
1994 |
Vaccine |
pmid:8165851
|
Faenzi E et al. |
One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies. |
2012 |
Vaccine |
pmid:22521851
|
Hatz C et al. |
A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations. |
2012 |
Vaccine |
pmid:22626675
|
Precioso AR et al. |
A phase I randomized, double-blind, controlled trial of 2009 influenza A (H1N1) inactivated monovalent vaccines with different adjuvant systems. |
2011 |
Vaccine |
pmid:21945258
|
Pariani E et al. |
Response to 2009 pandemic and seasonal influenza vaccines co-administered to HIV-infected and HIV-uninfected former drug users living in a rehabilitation community in Italy. |
2011 |
Vaccine |
pmid:21974995
|
Andrews NJ et al. |
Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. |
2011 |
Vaccine |
pmid:21875635
|
Barchfeld GL et al. |
The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. |
1999 |
Vaccine |
pmid:10067675
|
Iorio AM et al. |
Influenza viruses and cross-reactivity in healthy adults: humoral and cellular immunity induced by seasonal 2007/2008 influenza vaccination against vaccine antigens and 2009 A(H1N1) pandemic influenza virus. |
2012 |
Vaccine |
pmid:22245606
|
Frey SE et al. |
Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. |
2010 |
Vaccine |
pmid:20619382
|
Dupuis M et al. |
Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. |
1999 |
Vaccine |
pmid:10519932
|
Ott G et al. |
Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. |
1995 |
Vaccine |
pmid:8578842
|
Heineman TC et al. |
A randomized, controlled study in adults of the immunogenicity of a novel hepatitis B vaccine containing MF59 adjuvant. |
1999 |
Vaccine |
pmid:10438046
|
De Donato S et al. |
Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly. |
1999 |
Vaccine |
pmid:10462245
|
Tsai T et al. |
Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. |
2010 |
Vaccine |
pmid:19969117
|
Greer CE et al. |
The comparison of the effect of LTR72 and MF59 adjuvants on mouse humoral response to intranasal immunisation with human papillomavirus type 6b (HPV-6b) virus-like particles. |
2000 |
Vaccine |
pmid:11137233
|
Pietrella D et al. |
A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. |
2010 |
Vaccine |
pmid:20038431
|
Candela S et al. |
An early (3-6 weeks) active surveillance study to assess the safety of pandemic influenza vaccine Focetria in a province of Emilia-Romagna region, Italy - part one. |
2013 |
Vaccine |
pmid:22766247
|
Langley JM et al. |
Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study. |
2012 |
Vaccine |
pmid:22469860
|
Fukase H et al. |
Assessment of the immunogenicity and safety of varying doses of an MF59®-adjuvanted cell culture-derived A/H1N1 pandemic influenza vaccine in Japanese paediatric, adult and elderly subjects. |
2012 |
Vaccine |
pmid:22472791
|
Hatz C et al. |
A randomized clinical trial to identify the optimal antigen and MF59(®) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy adult and elderly subjects. |
2012 |
Vaccine |
pmid:22446638
|
Süli J et al. |
Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. |
2004 |
Vaccine |
pmid:15308373
|
BenÃsek Z et al. |
Experimental squalene adjuvant. II. Harmlessness and local reactogenity. |
2004 |
Vaccine |
pmid:15308374
|
O'Hagan DT et al. |
The mechanism of action of MF59 - an innately attractive adjuvant formulation. |
2012 |
Vaccine |
pmid:22682289
|
Okike IO et al. |
The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. |
2011 |
Vaccine |
pmid:21742005
|
Reynales H et al. |
A prospective observational safety study on MF59(®) adjuvanted cell culture-derived vaccine, Celtura(®) during the A/H1N1 (2009) influenza pandemic. |
2012 |
Vaccine |
pmid:22902681
|
Ventura R et al. |
Technology transfer of an oil-in-water vaccine-adjuvant for strengthening pandemic influenza preparedness in Indonesia. |
2013 |
Vaccine |
pmid:22884665
|
Della Cioppa G et al. |
Trivalent and quadrivalent MF59(®)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study. |
2011 |
Vaccine |
pmid:21906647
|
Moro ML et al. |
A population based cohort study to assess the safety of pandemic influenza vaccine Focetria in Emilia-Romagna region, Italy - part two. |
2013 |
Vaccine |
pmid:22885015
|
Fox CB et al. |
Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. |
2011 |
Vaccine |
pmid:21906648
|
Radosević K et al. |
Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants. |
2008 |
Vaccine |
pmid:18514980
|
Baldo V et al. |
MF59-adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications. |
2007 |
Vaccine |
pmid:17383057
|
Black S et al. |
Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis. |
2010 |
Vaccine |
pmid:20813217
|
Calabro S et al. |
The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. |
2013 |
Vaccine |
pmid:23684834
|
Skeiky YA et al. |
Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. |
2002 |
Vaccine |
pmid:12213399
|
de Bruijn I et al. |
Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly. |
2007 |
Vaccine |
pmid:18063446
|
Stephenson I et al. |
Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. |
2003 |
Vaccine |
pmid:12639491
|
Tetsutani K and Ishii KJ |
Adjuvants in influenza vaccines. |
2012 |
Vaccine |
pmid:23084848
|
Cristiani C et al. |
Safety of MF-59 adjuvanted vaccine for pandemic influenza: results of the vaccination campaign in an Italian health district. |
2011 |
Vaccine |
pmid:21396903
|
Meier S et al. |
Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children. |
2011 |
Vaccine |
pmid:21419775
|
Bråve A et al. |
Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. |
2007 |
Vaccine |
pmid:17707956
|
Parretta E et al. |
Italian post-marketing surveillance for adverse event reports after MF59-adjuvanted H1N1v vaccination. |
2011 |
Vaccine |
pmid:21406267
|
Ansaldi F et al. |
Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. |
2008 |
Vaccine |
pmid:18294741
|
Segura-Velázquez R et al. |
Influenza vaccine: development of a novel intranasal and subcutaneous recombinant adjuvant. |
2013 |
Vaccine |
pmid:23746458
|
Puig-Barberà J et al. |
MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. |
2013 |
Vaccine |
pmid:23731629
|
Van Buynder PG et al. |
The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly. |
2013 |
Vaccine |
pmid:23933368
|
Vinay TN et al. |
Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus). |
2013 |
Vaccine |
pmid:23896420
|
Poder A et al. |
An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. |
2014 |
Vaccine |
pmid:24252703
|