MeSH term | MeSH ID | Detail |
---|---|---|
Colonic Neoplasms | D003110 | 161 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Boar RB and Damps K | Resolution of 2,3-dihydrosqualene-2,3-diol, 10,11-dihydro-10,11-dihydroxyfarnesyl benzoate, and 6,7-dihydro-6,7-dihydroxygeranyl benzoate. Synthesis of (3R)- and (3S)-2,3-epoxy-2,3-dihydrosqualene. | 1977 | J. Chem. Soc. Perkin Trans. I | pmid:558213 |
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Wiss O and Wiss V | On the influence of cholesterol feeding and of a lipogenic diet on the cholesterogenesis in rat liver in vivo. | 1977 | Helv. Chim. Acta | pmid:599043 |
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Popják G | "As I remember it" research on biosynthesis of fatty acids, triglycerides, squalene, and cholesterol. | 1977 | J Am Oil Chem Soc | pmid:328555 |
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Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
Ono T et al. | Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system. | 1977 | Biochim. Biophys. Acta | pmid:403952 |
Phleger CF et al. | Membrane biosynthesis in swimbladders of deep sea fishes Coryphaenoides acrolepis and Antimora rostrata. | 1977 | Comp. Biochem. Physiol., B | pmid:830467 |
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Wood SG and Gottlieb D | Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. | 1978 | Biochem. J. | pmid:637849 |
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Wielgosz GJ and Armstrong DT | Effects of prolactin, progesterone, and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat. | 1978 | Can. J. Physiol. Pharmacol. | pmid:638868 |
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Amdur BH et al. | Presence of squalene in gram-positive bacteria. | 1978 | J. Bacteriol. | pmid:670148 |
Gavey KL and Scallen TJ | Studies on the conversion of enzymatically generated, microsome-bound squalene to sterol. | 1978 | J. Biol. Chem. | pmid:670211 |
Yamanishi Y et al. | Serum squalene levels in hepatobiliary diseases. | 1978 | Clin. Chim. Acta | pmid:679482 |
Kudchodkar BJ et al. | Mechanisms of hypolipidemic action of nicotinic acid. | 1978 | Clin. Pharmacol. Ther. | pmid:688728 |
Douglas TJ et al. | Inhibition of cholesterol biosynthesis in ovine ovarian follicles in vitro by human chorionic gonadotrophin. | 1978 | Aust. J. Biol. Sci. | pmid:571711 |
Tornabene TG | Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. | 1978 | J. Mol. Evol. | pmid:691076 |
Tornabene TG et al. | Phytanyl-glycerol ethers and squalenes in the archaebacterium Methanobacterium thermoautotrophicum. | 1978 | J. Mol. Evol. | pmid:691077 |
White SH | Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene. | 1978 | Biophys. J. | pmid:698340 |
Tilvis RS et al. | Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. | 1978 | Scand. J. Clin. Lab. Invest. | pmid:628820 |
Tiffany JM | Individual variations in human meibomian lipid composition. | 1978 | Exp. Eye Res. | pmid:710541 |
Saudek CD et al. | Plasma squalene: lipoprotein distribution and kinetic analysis. | 1978 | J. Lipid Res. | pmid:712242 |
Mironova VN and Chaialo PP | [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. | 1978 | Biull Eksp Biol Med | pmid:728610 |
Nishino T et al. | Synthesis of dehydrosqualene in microsomal fraction of Saccharomyces cerevisiae. | 1978 | Biochem. Biophys. Res. Commun. | pmid:32886 |
Yamawaki M et al. | Antitumor activity of squalene-treated cell-wall skeleton of Nocardia rubra in mice. | 1978 | Gan | pmid:103768 |
Patt TE and Hanson RS | Intracytoplasmic membrane, phospholipid, and sterol content of Methylobacterium organophilum cells grown under different conditions. | 1978 | J. Bacteriol. | pmid:96093 |
Goldberg I and Shechter I | Occurrence of squalene in methanol-grown bacteria. | 1978 | J. Bacteriol. | pmid:98521 |
Weeks OB and Francesconi MD | Occurrence of squalene and sterols in Cellulomonas dehydrogenans (Arnaudi 1942) comb. nov. Hester 1971. | 1978 | J. Bacteriol. | pmid:101527 |
Bertolino A et al. | Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. | 1978 | Biochim. Biophys. Acta | pmid:210830 |
Mills OH et al. | Enhancement of comedogenic substances by ultraviolet radiation. | 1978 | Br. J. Dermatol. | pmid:147099 |
Strauss JS et al. | Surface lipid composition in children with protein-calorie malnutrition. | 1978 | Am. J. Clin. Nutr. | pmid:414616 |
Anisimov MM et al. | [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. | 1978 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:724665 |
PerederiÄ OF and Morozova RP | [Squalene and sterols of rat stomach tissue and the effect of acetylsalicylic acid on their content]. | 1978 Nov-Dec | Ukr. Biokhim. Zh. | pmid:749299 |
PokrovskiÄ AA et al. | [Method of isolating, identifying and quantitatively determining alkanes, cycloalkanes, monocyclic arenes and squalene in animal organs and tissues]. | 1978 Sep-Oct | Vopr Pitan | pmid:716335 |
Pascaud A et al. | [Turnover of the endogenous free cholesterol of the hepatic cell plasma membrane sinusoids]. | 1979 | Biochimie | pmid:534664 |
Kushwaha SC and Kates M | Effect of glycerol on carotenogenesis in the extreme halophile, Halobacterium cutirubrum. | 1979 | Can. J. Microbiol. | pmid:540254 |
Kushwaha SC and Kates M | Studies of the biosynthesis of C50 carotenoids in Halobacterium cutirubrum. | 1979 | Can. J. Microbiol. | pmid:540255 |
Popják G and Agnew WS | Squalene synthetase. | 1979 | Mol. Cell. Biochem. | pmid:41173 |
Hirayama C et al. | Serum cholesterol and squalene in hepatocellular carcinoma. | 1979 | Clin. Chim. Acta | pmid:216506 |
Yarkoni E and Rapp HJ | Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil. | 1979 | Cancer Res. | pmid:427795 |
Nakamura M and Sato R | The roles of soluble factors in squalene epoxidation by rat liver microsomes. | 1979 | Biochem. Biophys. Res. Commun. | pmid:486208 |
Tornabene TG et al. | Squalenes, phytanes and other isoprenoids as major neutral lipids of methanogenic and thermoacidophilic "archaebacteria". | 1979 | J. Mol. Evol. | pmid:458874 |
Chang TY et al. | Inhibition of cholesterol biosynthesis in Chinese hamster ovary cells by 4,4,10 beta-trimethyl-trans-decal-3 beta-ol. A specific 2,3-oxidosqualene cyclase inhibitor. | 1979 | J. Biol. Chem. | pmid:500643 |
Caras IW and Bloch K | Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase. | 1979 | J. Biol. Chem. | pmid:500676 |
Kligman LH and Kligman AM | The effect on rhino mouse skin of agents which influence keratinization and exfoliation. | 1979 | J. Invest. Dermatol. | pmid:501133 |
Wysocki SJ et al. | Amniotic fluid squalene and fetal maturity. | 1979 | Br J Obstet Gynaecol | pmid:508672 |
Frier BM and Saudek CD | Cholesterol metabolism in diabetes: the effect of insulin on the kinetics of plasma squalene. | 1979 | J. Clin. Endocrinol. Metab. | pmid:511973 |
Adrangui M et al. | [Water-surfactant-oil diagrams based on perhydrosqualene and triglycerides (Miglyol 812). Study of emulsion phases and stability]. | 1979 | Pharm Acta Helv | pmid:515109 |
Yarkoni E and Rapp HJ | Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs. | 1980 | Infect. Immun. | pmid:6995325 |
Tilvis R and Miettinen TA | Squalene, methyl sterol, and cholesterol levels in human organs. Postmortem analysis of their distributions. | 1980 | Arch. Pathol. Lab. Med. | pmid:6892520 |
Cenedella RJ | Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. | 1980 | Biochem. Pharmacol. | pmid:6159896 |
Ohkido M et al. | Lipid peroxide of human skin. | 1980 | Curr. Probl. Dermatol. | pmid:6165521 |
Bouvier P et al. | Non-specific biosynthesis of gammacerane derivatives by a cell-free system from the protozoon Tetrahymena pyriformis. Conformations of squalene, (3S)-squalene epoxide and (3R)-squalene epoxide during the cyclization. | 1980 | Eur. J. Biochem. | pmid:6780347 |
Rohmer M et al. | Non-specific lanosterol and hopanoid biosynthesis be a cell-free system from the bacterium Methylococcus capsulatus. | 1980 | Eur. J. Biochem. | pmid:6780348 |
Miettinen TA | Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. | 1980 | Eur. J. Clin. Invest. | pmid:6768564 |
Bach D and Miller IR | Glyceryl monooleate black lipid membranes obtained from squalene solutions. | 1980 | Biophys. J. | pmid:7053057 |
Lindholm JS and Downing DT | Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. | 1980 | Lipids | pmid:7219074 |
Pimm MV et al. | Suppression of an ascitic rat hepatoma with cord factor and Nocardia cell wall skeleton in squalene emulsions. | 1980 | Eur J Cancer | pmid:7227439 |
McGinley KJ et al. | Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. | 1980 | J. Clin. Microbiol. | pmid:7276142 |
Friedlander EJ et al. | Supernatant protein factor facilitates intermembrane transfer of squalene. | 1980 | J. Biol. Chem. | pmid:7410347 |
Bell FP | Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. | 1980 | Bull Environ Contam Toxicol | pmid:7357111 |
Falcone DJ et al. | Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. | 1980 | Am. J. Pathol. | pmid:7361865 |
Caras IW et al. | Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. | 1980 | J. Biol. Chem. | pmid:7364757 |
Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
Shechter I et al. | A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. | 1980 | J. Lipid Res. | pmid:7381322 |
Srikantaiah MV et al. | Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins. | 1980 | Lipids | pmid:7432102 |
Rohmer M et al. | Non-specific biosynthesis of hopane triterpenes by a cell-free system from Acetobacter pasteurianum. | 1980 | Eur. J. Biochem. | pmid:7460938 |
Morin RJ and Srikantaiah MV | In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol. | 1980 | J. Lipid Res. | pmid:7462811 |
Soloway AH and LeQuesne PW | Potential endogenous mutagens/carcinogens. | 1980 | J. Theor. Biol. | pmid:7464159 |
Matsumoto G and Hanya T | Presence of squalane in urban aquatic environments. | 1980 | J. Chromatogr. | pmid:7410506 |
Strauss JS et al. | The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. | 1980 | J. Invest. Dermatol. | pmid:6444323 |
Schroepfer GJ | Sterol biosynthesis. | 1981 | Annu. Rev. Biochem. | pmid:7023367 |
Moroyama T | [Sterol metabolism of cultured skin tissue of chick embryo and the effect of anticholesterolemic drugs and chemical carcinogens on it (author's transl)]. | 1981 | Hiroshima Daigaku Shigaku Zasshi | pmid:6953141 |
Hunter MI et al. | The effect of temperature on the growth and lipid composition of the extremely halophilic coccus, Sarcina marina. | 1981 | Antonie Van Leeuwenhoek | pmid:7247392 |
Ito M et al. | Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. | 1981 | Cancer Res. | pmid:7248952 |