(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
NICHOLAS HJ and BOMBAUGH KJ CONSTITUENTS OF THE HYDROCARBON FRACTION OF BEEF BRAINS. 1965 Biochim. Biophys. Acta pmid:14320231
Tabacik C et al. Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. 1975 Biochim. Biophys. Acta pmid:1236745
Matyas GR et al. Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. 2009 Biochim. Biophys. Acta pmid:19100711
Taramino S et al. Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. 2010 Biochim. Biophys. Acta pmid:19879375
Kramer JK et al. Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. 1972 Biochim. Biophys. Acta pmid:5037322
Kushwaha SC et al. Isolation and identification of dehydrosqualene and C 40 -carotenoid pigments in Halobacterium cutirubrum. 1972 Biochim. Biophys. Acta pmid:5038263
Avigan J et al. In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. 1972 Biochim. Biophys. Acta pmid:5041430
MARKLEY K and GURIN S Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. 1959 Biochim. Biophys. Acta pmid:13628647
Horie M et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. 1993 Biochim. Biophys. Acta pmid:8504141
Bertolino A et al. Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. 1978 Biochim. Biophys. Acta pmid:210830
Rees HH et al. 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. 1969 Biochim. Biophys. Acta pmid:5797101
Pascaud A et al. [Turnover of the endogenous free cholesterol of the hepatic cell plasma membrane sinusoids]. 1979 Biochimie pmid:534664
Dosio F et al. Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation. 2010 Bioconjug. Chem. pmid:20597546
Passi S et al. The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. 2003 Biofactors pmid:14695946
Pasechnik VI [Cooperative analysis of measurements of capacity and optical parameters of bilayer lipid membranes]. 1983 Jan-Feb Biofizika pmid:6830905
Ivashkevich SP et al. [Effects of sterols having different chemical structure and squalene on osmotic resistance of erythrocytes]. 1981 Biokhimiia pmid:7272362
Davis TA et al. Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. 2001 Biol. Blood Marrow Transplant. pmid:11669219
Zauner W et al. Defined synthetic vaccines. 2001 Biol. Chem. pmid:11405222
Wysocki SJ et al. Lipids in forehead vernix from newborn infants. 1981 Biol. Neonate pmid:7260215
Ryu A et al. Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. 2009 Biol. Pharm. Bull. pmid:19721223
Kushiro T et al. In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. 1997 Biol. Pharm. Bull. pmid:9084891
Uchino T et al. Effect of squalene monohydroperoxide on cytotoxicity and cytokine release in a three-dimensional human skin model and human epidermal keratinocytes. 2002 Biol. Pharm. Bull. pmid:12033500
Piotrowski PC et al. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. 2006 Biol. Reprod. pmid:16571871
Palma P et al. Safety and immunogenicity of a monovalent MF59®-adjuvanted A/H1N1 vaccine in HIV-infected children and young adults. 2012 Biologicals pmid:22261282
Trung Bui D et al. Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. 2013 Biomacromolecules pmid:23829862
Chen WL et al. Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide. 2014 Biomaterials pmid:24268203
Xiao L et al. The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. 2010 Biomaterials pmid:20488530
Kawakami T et al. Squalane as a possible carrier of bone morphogenetic protein. 1993 Biomaterials pmid:8399948
Hillaireau H et al. Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies. 2013 Biomaterials pmid:23562054
Emmons GT et al. Effects of 20,25-diazacholesterol on cholesterol synthesis in cultured chick muscle cells: a radiogas chromatographic and mass spectrometric study of the post-squalene sector. 1982 Biomed. Mass Spectrom. pmid:7126761
Yoshino S Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. 1996 Biomed. Pharmacother. pmid:8672728
Kuroda Y et al. Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. 2004 Biomed. Pharmacother. pmid:15194169
Viola F et al. Stereospecific syntheses of trans-vinyldioxidosqualene and 3-hydroxysulfide derivatives, as potent and time-dependent 2,3-oxidosqualene cyclase inhibitors. 2000 Bioorg. Med. Chem. pmid:10968281
Gerpe A et al. 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. 2009 Bioorg. Med. Chem. pmid:19811923
Fernández JJ et al. Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. 1998 Bioorg. Med. Chem. pmid:9925286
Gerpe A et al. Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. 2008 Bioorg. Med. Chem. pmid:17981471
Galli U et al. Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. 2007 Bioorg. Med. Chem. Lett. pmid:17027267
Caron J et al. Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues. 2010 Bioorg. Med. Chem. Lett. pmid:20363623
Watanabe T et al. Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors. 2010 Bioorg. Med. Chem. Lett. pmid:20728352
Jagadish B et al. Squalene-derived flexible linkers for bioactive peptides. 2007 Bioorg. Med. Chem. Lett. pmid:17448660
Souto ML et al. The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. 2003 Bioorg. Med. Chem. Lett. pmid:12657259
Heinemann SH and Sigworth FJ Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. 1990 Biophys. J. pmid:1689592
White SH Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene. 1978 Biophys. J. pmid:698340
Lapointe JY and Laprade R Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. 1982 Biophys. J. pmid:6896832
Simon SA et al. The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. 1977 Biophys. J. pmid:880329
Salamon Z et al. Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties. 1997 Biophys. J. pmid:9370473
Armstrong KM and Cukierman S On the origin of closing flickers in gramicidin channels: a new hypothesis. 2002 Biophys. J. pmid:11867449
Crilly JF and Earnshaw JC Photon correlation spectroscopy of bilayer lipid membranes. 1983 Biophys. J. pmid:6838962
Bach D and Miller IR Glyceryl monooleate black lipid membranes obtained from squalene solutions. 1980 Biophys. J. pmid:7053057
Nakazawa A et al. Optimization of culture conditions of the thraustochytrid Aurantiochytrium sp. strain 18W-13a for squalene production. 2012 Bioresour. Technol. pmid:22023965