MeSH term | MeSH ID | Detail |
---|---|---|
Pneumonia, Lipid | D011017 | 2 associated lipids |
Steatorrhea | D045602 | 2 associated lipids |
Hemorrhagic Septicemia, Viral | D031941 | 1 associated lipids |
Persian Gulf Syndrome | D018923 | 1 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
TSAI SC et al. | TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. | 1964 | Arch. Biochem. Biophys. | pmid:14186739 |
Trocha PJ and Sprinson DB | Location and regulation of early enzymes of sterol biosynthesis in yeast. | 1976 | Arch. Biochem. Biophys. | pmid:7207 |
Oesch F et al. | Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. | 1971 | Arch. Biochem. Biophys. | pmid:5117530 |
Sasiak K and Rilling HC | Purification to homogeneity and some properties of squalene synthetase. | 1988 | Arch. Biochem. Biophys. | pmid:3277535 |
GAYLOR JL | Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. | 1963 | Arch. Biochem. Biophys. | pmid:13946925 |
BEELER DA et al. | The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. | 1963 | Arch. Biochem. Biophys. | pmid:13970235 |
Okada S et al. | Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. | 2004 | Arch. Biochem. Biophys. | pmid:14725863 |
POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |