MeSH term | MeSH ID | Detail |
---|---|---|
Fasciitis | D005208 | 2 associated lipids |
Ossification, Heterotopic | D009999 | 2 associated lipids |
Persian Gulf Syndrome | D018923 | 1 associated lipids |
Hemorrhagic Septicemia, Viral | D031941 | 1 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cherayil GD et al. | Abnormal lipid composition of fat tissue in human mesenteric panniculitis. | 1981 | Lipids | pmid:6163941 |
Cicchini T et al. | [The importance of man, mouse and rat skin surface lipid fractions on the "in vitro" penetration of "Schistosoma mansoni" cercariae (author's transl)]. | 1977 Sep-Oct | Ann Sclavo | pmid:616258 |
Cenedella RJ | Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. | 1980 | Biochem. Pharmacol. | pmid:6159896 |
Eilenberg H and Shechter I | A possible regulatory role of squalene epoxidase in Chinese hamster ovary cells. | 1984 | Lipids | pmid:6087072 |
Cain CE et al. | Hydrocarbons from human meninges and meningiomas. | 1967 | Biochim. Biophys. Acta | pmid:6078120 |
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van Tamelen EE et al. | Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6064361 |
Willett JD et al. | Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. | 1967 | J. Biol. Chem. | pmid:6061706 |
Arffmann E and Glavind J | Studies by the newt test on carcinogenic properties of rats. | 1967 | Acta Pathol Microbiol Scand | pmid:6050372 |
Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
Corey EJ and Gross SK | Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6046552 |
Young TE and Maggs RJ | The use of a moving wire detector system for the study of liquid chromatographic columns. | 1967 May-Jun | Anal. Chim. Acta | pmid:6045413 |
Corey EJ et al. | 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. | 1967 | J. Am. Chem. Soc. | pmid:6043808 |
van Tamelen EE et al. | On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6042776 |
Corey EJ and Ortiz de Montellano PR | Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6042774 |
Rao KS and Olson RE | The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. | 1967 | Biochem. Biophys. Res. Commun. | pmid:6030977 |
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Kellum RE | Short chain fatty acids (below C12) of human skin surface lipids. | 1967 | J. Invest. Dermatol. | pmid:6022603 |
Matschiner JT et al. | Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021953 |
Matschiner JT et al. | Effect of indigestible oils on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021812 |
Kellum RE | Human sebaceous gland lipids. Analysis by thin-layer chromatography. | 1967 | Arch Dermatol | pmid:6019001 |
Katsuki H and Bloch K | Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. | 1967 | J. Biol. Chem. | pmid:6016607 |
Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |
Cherkes AI and Klebanov BM | [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. | 1966 Nov-Dec | Farmakol Toksikol | pmid:6000378 |
Wiss O and Wiss V | On the influence of cholesterol feeding and of a lipogenic diet on the cholesterogenesis in rat liver in vivo. | 1977 | Helv. Chim. Acta | pmid:599043 |
Wiss O and Wiss V | The influence of fasting on the synthesis of cholesterol, squalene, fatty acids, and ubiquinones in liver, small intestine, and kidney of rats in vivo. | 1977 | Helv. Chim. Acta | pmid:599042 |
Van Tamelen EE et al. | Nonenzymic laboratory cyclization of squalene 2,3-oxide. | 1966 | J. Am. Chem. Soc. | pmid:5980879 |
Brooks CJ et al. | Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. | 1966 | Biochim. Biophys. Acta | pmid:5973204 |
Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |
Williams RJ et al. | A possible mechanism for the biosynthesis of eschscholtzxanthin. | 1966 | Biochim. Biophys. Acta | pmid:5966716 |
Paoletti P et al. | Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. | 1966 | Neurochirurgia (Stuttg) | pmid:5966653 |
Zelewski L and Villee CA | The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta. | 1966 | Biochemistry | pmid:5963423 |
Ismail AA et al. | Interrelation between thyroid hormones and essential fatty acids. | 1966 | Acta Physiol Acad Sci Hung | pmid:5953398 |
Butterworth PH et al. | In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. | 1966 | Arch. Biochem. Biophys. | pmid:5944963 |
Hsia SL et al. | Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. | 1966 | J. Invest. Dermatol. | pmid:5924299 |
Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
Van Tamelen EE et al. | Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. | 1966 | J. Am. Chem. Soc. | pmid:5918048 |
Corey EJ and Russey WE | Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. | 1966 | J. Am. Chem. Soc. | pmid:5918047 |
Cory EJ et al. | 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. | 1966 | J. Am. Chem. Soc. | pmid:5918046 |
Goodwin TW and Williams RJ | A mechanism for the biosynthesis of alpha-carotene. | 1965 | Biochem. J. | pmid:5881648 |
Garbuzov AG et al. | [The presence of squalene in the human aorta]. | 1965 | Arkh. Patol. | pmid:5881137 |
Paroli E | [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. | 1964 | Boll. Soc. Ital. Biol. Sper. | pmid:5877121 |
Kipping D | [Observations on skin surface fats]. | 1965 | Z Haut Geschlechtskr | pmid:5860995 |
Van Leusden H and Villee CA | The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. | 1965 | Steroids | pmid:5857495 |
Malathi P and Ganguly J | Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. | 1964 | Biochem. J. | pmid:5837438 |
Higgins MJ and Kekwick RG | The role of malonyl-coenzyme A in isoprenoid biosynthesis. | 1969 | Biochem. J. | pmid:5807201 |
Yamamoto S and Bloch K | On the enzymes catalysing the transformation of squalene to lanosterol. | 1969 | Biochem. J. | pmid:5807185 |
Foti L et al. | Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. | 1969 | Life Sci. | pmid:5804653 |
Miettinen TA | Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. | 1969 | Life Sci. | pmid:5801489 |