MeSH term | MeSH ID | Detail |
---|---|---|
Alzheimer Disease | D000544 | 76 associated lipids |
Alopecia Areata | D000506 | 6 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Acne Vulgaris | D000152 | 35 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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GOODMAN DS | Studies on the conversion of squalene to sterol with rat liver enzymes. | 1961 | J. Biol. Chem. | pmid:13707027 |
GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
CAPSTACK E et al. | The biosynthesis of squalene in germinating seeds of Pisum sativum. | 1962 | Biochemistry | pmid:14018475 |
ALAM SQ et al. | Detection and estimation of squalene in leaves. | 1962 | Nature | pmid:13860005 |
GOSSELIN L et al. | Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. | 1962 | Nature | pmid:13900654 |
GOSSELIN L | Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. | 1962 | Arch. Int. Physiol. Biochim. | pmid:13900655 |
CHILDS CR and BLOCH K | Further observations on the biosynthesis of squalene. | 1962 | J. Biol. Chem. | pmid:13878983 |
HOLMES WL and STACK E | Gas chromatography of squalene, sterols and bile acid methyl esters. | 1962 | Biochim. Biophys. Acta | pmid:13908533 |
POPJAK G et al. | Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. | 1962 | J. Biol. Chem. | pmid:14487886 |
POPJAK G et al. | Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14487887 |
ROTHBLAT GH et al. | A quantitative colorimetric assay for squalene. | 1962 | Anal. Biochem. | pmid:14494417 |
HORLICK L and AVIGAN J | STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. | 1963 | J. Lipid Res. | pmid:14168146 |
LUPIEN PJ et al. | EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. | 1963 | Can J Biochem Physiol | pmid:14083981 |
GRIESEMER RD and THOMAS RW | LIPOGENESIS IN HUMAN SKIN. II. THE EFFECT OF PHYSICAL AND CHEMICAL FACTORS ON IN VITRO LIPOGENESIS FROM ACETATE. | 1963 | J. Invest. Dermatol. | pmid:14059599 |
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GRIESEMER RD and THOMAS RW | LIPOGENESIS IN HUMAN SKIN. III. VARIATION WITH BODY SITE. | 1963 | J. Invest. Dermatol. | pmid:14066602 |
PROSTENIK M and MUNK-WEINERT M | The isolation of squalene from human brain. | 1963 | Biochim. Biophys. Acta | pmid:13986372 |
BURGESS TL and WILSON JD | Studies on hormonal regulation of squalene synthesis in preputial gland and skin of the rat. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:14016990 |
CALTABIANO S and SPREMOLLA G | [Histological and humoral aspects of experimental atherosclerosis induced by squalene in rabbits treated with triparanol]. | 1963 | Arch Sci Med (Torino) | pmid:14017944 |
CARAVACA J et al. | Inhibition of squalene and cholesterol biosynthesis by hepatocatalase (Caperase). | 1963 | Biochem. Biophys. Res. Commun. | pmid:14018515 |
CORNFORTH JW et al. | Stereospecific insertion of hydrogen atom into squalene from reduced nicotinamide-adenine dinucleotides. | 1963 | Biochem. Biophys. Res. Commun. | pmid:14023096 |
GAYLOR JL | Biosynthesis of skin sterols. III. Conversion of squalene to sterols by rat skin. | 1963 | J. Biol. Chem. | pmid:13946923 |
GAYLOR JL | Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. | 1963 | Arch. Biochem. Biophys. | pmid:13946925 |
JACHYMCZYK W | [Biosynthesis of triterpenoid compounds]. | 1963 | Postepy Biochem. | pmid:13957182 |
BEELER DA et al. | The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. | 1963 | Arch. Biochem. Biophys. | pmid:13970235 |
SAMUELSSON B and GOODMAN DS | Stereochemistry of the hydrogen transfer to squalene during its biosynthesis from farnesyl pyrophosphate. | 1963 | Biochem. Biophys. Res. Commun. | pmid:13976173 |
Malathi P and Ganguly J | Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. | 1964 | Biochem. J. | pmid:5837438 |
GOODMAN DS | SQUALENE IN HUMAN AND RAT BLOOD PLASMA. | 1964 | J. Clin. Invest. | pmid:14192529 |
SALOKANGAS RA et al. | TERPENE METABOLISM IN THE RAT TESTIS. I. THE CONVERSION OF ISOPENTENYL PYROPHOSPHATE TO SQUALENE AND STEROLS. | 1964 | Biochemistry | pmid:14211625 |
MCCARTHY MJ et al. | COMPOSITION OF MOLECULAR DISTILLATES OF BUTTER OIL: ISOLATION AND IDENTIFICATION OF COMPONENTS OTHER THAN GLYCERIDES. | 1964 | J. Lipid Res. | pmid:14221107 |
TSAI SC et al. | TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. | 1964 | Arch. Biochem. Biophys. | pmid:14186739 |
VAN DEN OORD A | THE ABSENCE OF CHOLESTEROL SYNTHESIS IN THE CRAB, CANCER PAGURUS L. | 1964 | Comp. Biochem. Physiol. | pmid:14246359 |
DILLER ER and HARVEY OA | INTERRELATIONSHIP OF STEROL AND FATTY ACID BIOSYNTHESIS IN RAT LIVER SLICES AS RELATED TO DIETARY LIPID. | 1964 | Biochemistry | pmid:14269326 |
SAMUELSSON B and GOODMAN DS | STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL. | 1964 | J. Biol. Chem. | pmid:14114881 |
ALEXANDER GJ and ALEXANDER RB | INHIBITION OF CHOLESTEROL SYNTHESIS IN VIVO BY A CONVULSANT, METRAZOL. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14117448 |
BROOKS SC and GODEFROI VC | QUANITITATIVE COLLECTION OF MICRO AMOUNTS OF STEROIDS FROM GAS-LIQUID CHROMATOGRAPHY. | 1964 | Anal. Biochem. | pmid:14134426 |
LUCY JA and DINGLE JT | FAT-SOLUBLE VITAMINS AND BIOLOGICAL MEMBRANES. | 1964 | Nature | pmid:14222261 |
Krishna G et al. | An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene. | 1964 | Biochem. Biophys. Res. Commun. | pmid:4284347 |
Gosselin L | [Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides]. | 1964 | Arch. Int. Physiol. Biochim. | pmid:4157959 |
Paroli E | [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. | 1964 | Boll. Soc. Ital. Biol. Sper. | pmid:5877121 |
KARLSON P | [NOBEL PRIZE FOR MEDICINE AND PHYSIOLOGY IN 1964]. | 1965 | Dtsch. Med. Wochenschr. | pmid:14238764 |
CORNFORTH JW et al. | THE MIGRATION AND ELIMINATION OF HYDROGEN DURING BIOSYNTHESIS OF CHOLESTEROL FROM SQUALENE. | 1965 | J. Am. Chem. Soc. | pmid:14329430 |
DIPLOCK AT et al. | VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. | 1965 | Biochem. J. | pmid:14333548 |
VROMAN HE and BAKER GL | LIMITS OF DETECTION OF SOME LIPIDS IN THIN-LAYER CHROMATOGRAPHY. | 1965 | J. Chromatogr. | pmid:14334204 |
GOSSELIN L and DUVIVIER J | [BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE]. | 1965 | Bull. Soc. Chim. Biol. | pmid:14337120 |
GOODWIN TW and WILLIAMS RJ | A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. | 1965 | Biochem. J. | pmid:14342248 |
SHORB MS et al. | EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14277681 |
Stone KJ and Hemming FW | The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. | 1965 | Biochem. J. | pmid:4284430 |
Garbuzov AG et al. | [The presence of squalene in the human aorta]. | 1965 | Arkh. Patol. | pmid:5881137 |
Goodwin TW and Williams RJ | A mechanism for the biosynthesis of alpha-carotene. | 1965 | Biochem. J. | pmid:5881648 |