(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Alopecia Areata D000506 6 associated lipids
Adenocarcinoma D000230 166 associated lipids
Acne Vulgaris D000152 35 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Van Leusden H and Villee CA The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. 1965 Steroids pmid:5857495
Kipping D [Observations on skin surface fats]. 1965 Z Haut Geschlechtskr pmid:5860995
KARLSON P [NOBEL PRIZE FOR MEDICINE AND PHYSIOLOGY IN 1964]. 1965 Dtsch. Med. Wochenschr. pmid:14238764
CORNFORTH JW et al. THE MIGRATION AND ELIMINATION OF HYDROGEN DURING BIOSYNTHESIS OF CHOLESTEROL FROM SQUALENE. 1965 J. Am. Chem. Soc. pmid:14329430
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548
Stone KJ and Hemming FW The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. 1965 Biochem. J. pmid:4284430
Garbuzov AG et al. [The presence of squalene in the human aorta]. 1965 Arkh. Patol. pmid:5881137
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648
Cornforth JW et al. Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. 1966 Proc. R. Soc. Lond., B, Biol. Sci. pmid:4379289
Cornforth JW et al. Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. 1966 Proc. R. Soc. Lond., B, Biol. Sci. pmid:4379291
Blondin GA et al. The biosynthesis of squalene and sterols in fish. 1966 Comp. Biochem. Physiol. pmid:4380202
Krishna G et al. Enzymic conversion of farnesyl pyrophosphate to squalene. 1966 Arch. Biochem. Biophys. pmid:4380977
Akhtar M et al. The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol. 1966 Biochem. J. pmid:4381706
Villee CA et al. The regulation of the biosynthesis of sterols and steroids in the placenta. 1966 Adv. Enzyme Regul. pmid:4862939
Rilling HC A new intermediate in the biosynthesis of squalene. 1966 J. Biol. Chem. pmid:4287912
Gaylor JL et al. Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. 1966 J. Lipid Res. pmid:4290536
Lynen F [The biochemical basis of the biosynthesis of cholesterol and fatty acids]. 1966 Wien. Klin. Wochenschr. pmid:4296920
Ismail AA et al. Interrelation between thyroid hormones and essential fatty acids. 1966 Acta Physiol Acad Sci Hung pmid:5953398
Zelewski L and Villee CA The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta. 1966 Biochemistry pmid:5963423
Paoletti P et al. Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. 1966 Neurochirurgia (Stuttg) pmid:5966653
Williams RJ et al. A possible mechanism for the biosynthesis of eschscholtzxanthin. 1966 Biochim. Biophys. Acta pmid:5966716
Cory EJ et al. 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. 1966 J. Am. Chem. Soc. pmid:5918046
Corey EJ and Russey WE Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. 1966 J. Am. Chem. Soc. pmid:5918047
Van Tamelen EE et al. Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. 1966 J. Am. Chem. Soc. pmid:5918048
Cmelik SH and Webster GD Squalene in vernix caseosa from African neonates. 1966 Cent Afr J Med pmid:5919884
Hsia SL et al. Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. 1966 J. Invest. Dermatol. pmid:5924299
Butterworth PH et al. In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. 1966 Arch. Biochem. Biophys. pmid:5944963
Chesterton CJ The subcellular site of cholesterol synthesis in rat liver. 1966 Biochem. Biophys. Res. Commun. pmid:5971766
Brooks CJ et al. Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. 1966 Biochim. Biophys. Acta pmid:5973204
Van Tamelen EE et al. Nonenzymic laboratory cyclization of squalene 2,3-oxide. 1966 J. Am. Chem. Soc. pmid:5980879
Hellig HR and Savard K Sterol biosynthesis in the bovine corpus luteum in vitro. 1966 Biochemistry pmid:6006805
Garbuzov AG et al. Presence of squalene in human aorta. 1966 May-Jun Fed Proc Transl Suppl pmid:5222095
Cherkes AI and Klebanov BM [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. 1966 Nov-Dec Farmakol Toksikol pmid:6000378
Rao KS and Olson RE The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. 1967 Biochem. Biophys. Res. Commun. pmid:6030977
Short RV The synthesis and secretion of steroids by the corpus luteum. 1967 Arch Anat Microsc Morphol Exp pmid:4973334
Johnson WS Nonenzymic biogenetic-like olefinic cyclizations. 1967 Trans N Y Acad Sci pmid:5237390
Benveniste P et al. [Biosynthesis of squalene with the help of microsomes originating from the tissue of tobacco cultivated in vitro]. 1967 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4967365
Willett JD et al. Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. 1967 J. Biol. Chem. pmid:6061706
van Tamelen EE et al. Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. 1967 J. Am. Chem. Soc. pmid:6064361
Kishi M et al. Acid-catalyzed cyclization of squalene oxide. 1967 Chem. Pharm. Bull. pmid:5583148
Schubert K and Schumann W [On the biosynthesis of sterines]. 1967 Acta Biol. Med. Ger. pmid:5593407
Corey EJ and Ortiz de Montellano PR Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. 1967 J. Am. Chem. Soc. pmid:6042774
van Tamelen EE et al. On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. 1967 J. Am. Chem. Soc. pmid:6042776
Corey EJ et al. 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. 1967 J. Am. Chem. Soc. pmid:6043808
Corey EJ and Gross SK Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. 1967 J. Am. Chem. Soc. pmid:6046552
Rao KS and Olson RE The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. 1967 Biochim. Biophys. Acta pmid:6049507
Katsuki H and Bloch K Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. 1967 J. Biol. Chem. pmid:6016607
Kellum RE Human sebaceous gland lipids. Analysis by thin-layer chromatography. 1967 Arch Dermatol pmid:6019001
Matschiner JT et al. Effect of indigestible oils on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021812
Matschiner JT et al. Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021953