MeSH term | MeSH ID | Detail |
---|---|---|
Alzheimer Disease | D000544 | 76 associated lipids |
Alopecia Areata | D000506 | 6 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Acne Vulgaris | D000152 | 35 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ferguson JB and Bloch K | Purification and properties of a soluble protein activator of rat liver squalene epoxidase. | 1977 | J. Biol. Chem. | pmid:885856 |
Bonté F et al. | Simarouba amara extract increases human skin keratinocyte differentiation. | 1996 | J Ethnopharmacol | pmid:8844461 |
Mark M et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820110 |
Gloor M and Kohler H | A contribution to a new test method for dandruff-inhibiting and "keratolytic" action of drugs. | 1977 | Eur. J. Clin. Pharmacol. | pmid:880976 |
Simon SA et al. | The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. | 1977 | Biophys. J. | pmid:880329 |
Piretti MV et al. | Simultaneous reversed-phase high-performance liquid chromatographic separation of non-polar isoprenoid lipids and their determination. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8788146 |
Airaudi D et al. | In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. | 1996 Jan-Feb | Mycoses | pmid:8786759 |
Higgins DA et al. | MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. | 1996 | Vaccine | pmid:8782343 |
Miquel K et al. | Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780704 |
Arthington-Skaggs BA et al. | Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. | 1996 | FEBS Lett. | pmid:8772195 |
Keefer MC et al. | Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8744579 |
Lakshmanan MR and Veech RL | Measurement of rate of rat liver sterol synthesis in vivo using tritiated water. | 1977 | J. Biol. Chem. | pmid:873910 |
Chan P et al. | Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. | 1996 | J Clin Pharmacol | pmid:8739021 |
Gylling H et al. | The metabolism of cholestanol in primary biliary cirrhosis. | 1996 | J. Hepatol. | pmid:8738731 |
Fogelman AM et al. | Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. | 1977 | Biochem. Biophys. Res. Commun. | pmid:869944 |
Yamada Y et al. | Oxidation of linear terpenes and squalene variants by Arthrobacter sp. | 1977 | Appl. Environ. Microbiol. | pmid:869527 |
Fan SR et al. | Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. | 1996 | Mutat. Res. | pmid:8692222 |
Barth MM et al. | Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. | 1996 | J. Med. Chem. | pmid:8691425 |
Yoshino S | Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. | 1996 | Biomed. Pharmacother. | pmid:8672728 |
Ito T et al. | Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. | 1996 | Gastroenterology | pmid:8613070 |