MeSH term | MeSH ID | Detail |
---|---|---|
Alzheimer Disease | D000544 | 76 associated lipids |
Alopecia Areata | D000506 | 6 associated lipids |
Adenocarcinoma | D000230 | 166 associated lipids |
Acne Vulgaris | D000152 | 35 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yamamoto S and Bloch K | Enzymatic studies on the oxidative cyclizations of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4400141 |
Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
Popják G | Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4332649 |
Yamamoto S | [Oxidative cyclization of squalene. Biosynthesis of sterols]. | 1970 | Tanpakushitsu Kakusan Koso | pmid:4912088 |
Epstein WW and Rilling HC | Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. | 1970 | J. Biol. Chem. | pmid:4318477 |
Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
Robinson DR and West CA | Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. I. Identification of diterpene hydrocarbons formed from mevalonate. | 1970 | Biochemistry | pmid:5411208 |
Ramasastry P et al. | Chemical composition of human skin surface lipids from birth to puberty. | 1970 | J. Invest. Dermatol. | pmid:5414607 |
Sloviter HA et al. | Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. | 1970 | J. Lipid Res. | pmid:5418482 |
Sargent JR et al. | Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. | 1970 | Biochem. J. | pmid:5420034 |
Miettinen TA et al. | Serum squalene and methyl sterols. | 1970 | N. Engl. J. Med. | pmid:5470273 |
Peter G et al. | [Gas chromatographic examinations of sebaceous gland lipids. I. Total lipid determination]. | 1970 | Arch Klin Exp Dermatol | pmid:5477881 |
el-Ibrashy MT and Mansour MH | Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae. | 1970 | Experientia | pmid:5483755 |
Pochi PE et al. | Sebaceous gland response in man to prolonged total caloric deprivation. | 1970 | J. Invest. Dermatol. | pmid:5483834 |
Kligman AM et al. | Comedogenicity of human sebum. | 1970 | Arch Dermatol | pmid:4247928 |
Godinez MH et al. | The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. | 1970 | Arch. Biochem. Biophys. | pmid:5460184 |
Caspi E and Mulheirn LJ | Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid. | 1970 | J. Am. Chem. Soc. | pmid:5460747 |
Villee CA | Shark oil and medicine. | 1970 | N. Engl. J. Med. | pmid:5462581 |
Stefanovich V and Kajiyama G | Squalene and cholestanol in normal rabbit aorta. | 1970 May-Jun | Atherosclerosis | pmid:5433085 |
Habczyńska D et al. | [The effect of squalene and cholesterol on the histological picture of the periodontium in white rats]. | 1970 Oct-Nov | Czas Stomatol | pmid:5274119 |
Scallen TJ et al. | Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder. | 1971 | Lipids | pmid:4396848 |
Ferne M et al. | [Isolation and characterization of various membrane fractions type active in the synthesis in vitro of squalene and obtained from anergic tissue cultures of tobacco]. | 1971 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4997022 |
Nes WR | Regulation of the sequencing in sterol biosynthesis. | 1971 | Lipids | pmid:4997338 |
Anding C et al. | Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. | 1971 | Eur. J. Biochem. | pmid:5003307 |
Dean PD | The cyclases of triterpene and sterol biosynthesis. | 1971 | Steroidologia | pmid:5004310 |
Bird CW et al. | Steroids and squalene in Methylococcus capsulatus grown on methane. | 1971 | Nature | pmid:4929985 |
van Leusden HA et al. | Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. | 1971 | Acta Endocrinol. | pmid:5108099 |
Oesch F et al. | Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. | 1971 | Arch. Biochem. Biophys. | pmid:5117530 |
Woods RA | Nystatin-resistant mutants of yeast: alterations in sterol content. | 1971 | J. Bacteriol. | pmid:5122815 |
Popják G | Specificity of enzymes of sterol biosynthesis. | 1971 | Harvey Lect. | pmid:5123650 |
Smith AG and Goad LJ | Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. | 1971 | Biochem. J. | pmid:5126917 |
Wells JW | Steroids in the pineal gland of the domestic fowl (Gallus domesticus): cholesterol and its biosynthesis. | 1971 | Comp. Biochem. Physiol., B | pmid:5133342 |
van Tamelen EE et al. | Formation of A-B cis- and trans-19-norlanosterols by enzymic cyclization of 6'-norsqualene 2,3-oxide. | 1971 | J. Am. Chem. Soc. | pmid:5135874 |
Chida N and Okamura T | Increased cholesterol-biosynthesis in familial hypercholesterolemia. | 1971 | Tohoku J. Exp. Med. | pmid:5140375 |
Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |
Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
Goodwin TW | Biosynthesis of carotenoids and plant triterpenes. | 1971 | Biochem. J. | pmid:4331177 |
Bloxham DP and Akhtar M | Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. | 1971 | Biochem. J. | pmid:4331371 |
Green TR and Baisted DJ | Development of the squalene-synthesizing system during early stages of pea seed germination. | 1971 | Biochem. J. | pmid:4335540 |
Cotterill JA et al. | Sebum excretion rate and biochemistry in patients with acne vulgaris treated by oral fenfluramine. | 1971 | Br. J. Dermatol. | pmid:4255130 |
Cotterill JA et al. | The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris. | 1971 | Br. J. Dermatol. | pmid:4255131 |
Summerly R and Woodbury S | The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland. | 1971 | Br. J. Dermatol. | pmid:4257140 |
Cuncliffe WJ et al. | Skin surface lipids in acne. | 1971 | Br. J. Dermatol. | pmid:4257142 |
Peter G and Peter R | [Studies on the composition of palmar skin surface fat in relation to age and its biochemical bases]. | 1971 | Arch Dermatol Forsch | pmid:5571755 |
Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro. | 1971 | Lipids | pmid:5574907 |
Daly MM | Biosynthesis of squalene and sterols by rat aorta. | 1971 | J. Lipid Res. | pmid:5579265 |
Aaronson S | Inhibition of yeast multiplication by hypocholesteremic compounds and its annulment by lipids. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:5540639 |
Corey EJ et al. | Conversion of des-6-methyl-2,3-oxidosqualene to 19-norlanosterol by 2,3-oxidosqualene-sterol cyclase. | 1971 | J. Am. Chem. Soc. | pmid:5548348 |
Altman LJ et al. | Synthesis and conversion of presqualene alcohol to squalene. | 1971 | J. Am. Chem. Soc. | pmid:5550251 |
Coates RM and Robinson WH | Stereoselective total synthesis of (plus or minus)-presqualene alcohol. | 1971 | J. Am. Chem. Soc. | pmid:5550252 |