MeSH term | MeSH ID | Detail |
---|---|---|
Pneumonia, Lipid | D011017 | 2 associated lipids |
Persian Gulf Syndrome | D018923 | 1 associated lipids |
Steatorrhea | D045602 | 2 associated lipids |
Hemorrhagic Septicemia, Viral | D031941 | 1 associated lipids |
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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DIPLOCK AT et al. | VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. | 1965 | Biochem. J. | pmid:14333548 |
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GOSSELIN L and DUVIVIER J | [BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE]. | 1965 | Bull. Soc. Chim. Biol. | pmid:14337120 |
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Goodwin TW and Williams RJ | A mechanism for the biosynthesis of alpha-carotene. | 1965 | Biochem. J. | pmid:5881648 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379289 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379291 |
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Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
Hsia SL et al. | Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. | 1966 | J. Invest. Dermatol. | pmid:5924299 |
Butterworth PH et al. | In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. | 1966 | Arch. Biochem. Biophys. | pmid:5944963 |
Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |
Brooks CJ et al. | Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. | 1966 | Biochim. Biophys. Acta | pmid:5973204 |
Van Tamelen EE et al. | Nonenzymic laboratory cyclization of squalene 2,3-oxide. | 1966 | J. Am. Chem. Soc. | pmid:5980879 |
Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |
Garbuzov AG et al. | Presence of squalene in human aorta. | 1966 May-Jun | Fed Proc Transl Suppl | pmid:5222095 |
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Rao KS and Olson RE | The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. | 1967 | Biochem. Biophys. Res. Commun. | pmid:6030977 |
Short RV | The synthesis and secretion of steroids by the corpus luteum. | 1967 | Arch Anat Microsc Morphol Exp | pmid:4973334 |
Johnson WS | Nonenzymic biogenetic-like olefinic cyclizations. | 1967 | Trans N Y Acad Sci | pmid:5237390 |
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Nightingale MS et al. | Testicular sterols. VI. Incorporation of mevalonate into squalene and sterols by cell-free preparations of testicular tissue. | 1967 | J. Biol. Chem. | pmid:4290213 |
Willett JD et al. | Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. | 1967 | J. Biol. Chem. | pmid:6061706 |
van Tamelen EE et al. | Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6064361 |
Kishi M et al. | Acid-catalyzed cyclization of squalene oxide. | 1967 | Chem. Pharm. Bull. | pmid:5583148 |
Corey EJ and Ortiz de Montellano PR | Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6042774 |
van Tamelen EE et al. | On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6042776 |
Corey EJ et al. | 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. | 1967 | J. Am. Chem. Soc. | pmid:6043808 |
Corey EJ and Gross SK | Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6046552 |
Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
Katsuki H and Bloch K | Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. | 1967 | J. Biol. Chem. | pmid:6016607 |
Kellum RE | Human sebaceous gland lipids. Analysis by thin-layer chromatography. | 1967 | Arch Dermatol | pmid:6019001 |
Matschiner JT et al. | Effect of indigestible oils on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021812 |
Matschiner JT et al. | Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021953 |