| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemorrhagic Septicemia, Viral | D031941 | 1 associated lipids |
| Persian Gulf Syndrome | D018923 | 1 associated lipids |
| Fasciitis | D005208 | 2 associated lipids |
| Ossification, Heterotopic | D009999 | 2 associated lipids |
| Pneumonia, Lipid | D011017 | 2 associated lipids |
| Steatorrhea | D045602 | 2 associated lipids |
| Gallbladder Diseases | D005705 | 3 associated lipids |
| Exostoses, Multiple Hereditary | D005097 | 3 associated lipids |
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Coronavirus Infections | D018352 | 4 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| GAYLOR JL | Biosynthesis of skin sterols. III. Conversion of squalene to sterols by rat skin. | 1963 | J. Biol. Chem. | pmid:13946923 |
| HOLMES WL and STACK E | Gas chromatography of squalene, sterols and bile acid methyl esters. | 1962 | Biochim. Biophys. Acta | pmid:13908533 |
| GOSSELIN L | Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. | 1962 | Arch. Int. Physiol. Biochim. | pmid:13900655 |
| GOSSELIN L et al. | Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. | 1962 | Nature | pmid:13900654 |
| CHILDS CR and BLOCH K | Further observations on the biosynthesis of squalene. | 1962 | J. Biol. Chem. | pmid:13878983 |
| ALAM SQ et al. | Detection and estimation of squalene in leaves. | 1962 | Nature | pmid:13860005 |
| NICHOLAS HJ and THOMAS BE | Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. | 1959 | Biochim. Biophys. Acta | pmid:13854106 |
| GOODMAN DS and POPJAK G | Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes. | 1960 | J. Lipid Res. | pmid:13851061 |
| KROENING F | [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. | 1959 | Acta Unio Int Contra Cancrum | pmid:13848508 |
| WITTING LA and PORTER JW | Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. | 1959 | J. Biol. Chem. | pmid:13845505 |
| WOOTTON JM and WRIGHT LD | Biosynthesis of squalene by the annelid Lumbricus terrestris. | 1960 | Nature | pmid:13786660 |
| MELCHIORRI-SANTOLINI U and RENZINI G | [Detection of sterols and squalene in sporigenic bacteria]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13769177 |
| SEDEE PD | Intermediary metabolism in aseptically reared blowfly larvae, Calliphora erythrocephala (Meig.). I. Buosynthesis of squalene and cholesterol. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13749584 |
| RENZINI G | [Detection of sterols and squalene in B. coli aerogenes]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13740904 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. | 1961 | J. Biol. Chem. | pmid:13737104 |
| POPJAK G et al. | Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate. | 1961 | Biochem. Biophys. Res. Commun. | pmid:13737103 |
| PATTERSON JF | Biosynthesis of squalene by rat preputial gland. | 1960 | Proc. Soc. Exp. Biol. Med. | pmid:13733368 |
| Cooper MF et al. | Sebaceous lipogenesis and androgen metabolism in acne. | 1976 | Biochem. Soc. Trans. | pmid:137154 |
| GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
| GOODMAN DS | Studies on the conversion of squalene to sterol with rat liver enzymes. | 1961 | J. Biol. Chem. | pmid:13707027 |
| GAYLOR JL | Anaerobic conversion of acetate to squalene by rat skin. | 1961 | Proc. Soc. Exp. Biol. Med. | pmid:13704081 |
| ANDERSON DG et al. | The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. | 1960 | Biochem. Biophys. Res. Commun. | pmid:13683185 |
| Kushwaha SC and Kates M | Lipid composition of Neurospora crassa. | 1976 | Lipids | pmid:136584 |
| RILLING HC and BLOCH K | On the mechanism of squaiene biogenesis from mevalonic acid. | 1959 | J. Biol. Chem. | pmid:13654391 |
| MARKLEY K and GURIN S | Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. | 1959 | Biochim. Biophys. Acta | pmid:13628647 |
| LOUD AV and BUCHER NL | The turnover of squalene in relation to the biosynthesis of cholesterol. | 1958 | J. Biol. Chem. | pmid:13563436 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13546172 |
| Gloor M | [The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)]. | 1976 | Z. Hautkr. | pmid:13544 |
| EIDINOFF ML et al. | Cholesterol biosynthesis: studies related to the metabolic role of squalene. | 1958 | J. Clin. Invest. | pmid:13539207 |
| WOLFF RE and PICHAT L | [Synthesis of 11,14-C14-squalene]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537435 |
| WOLFF RE and GODEFROY N | [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537384 |
| CORNFORTH JW et al. | Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13535596 |
| DITURI F et al. | Precursors of squalene and cholesterol. | 1957 | J. Biol. Chem. | pmid:13502345 |
| SOBEL H et al. | Determinations of squalene in sebum from the forehead of patients with skin cancer. | 1957 | J. Invest. Dermatol. | pmid:13491890 |
| TCHEN TT and BLOCH K | On the mechanism of enzymatic cyclization of squalene. | 1957 | J. Biol. Chem. | pmid:13438882 |
| TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
| HELLER JH et al. | Squalene content of various shark livers. | 1957 | Nature | pmid:13430738 |
| BOUGHTON B et al. | Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. | 1957 | Biochem. J. | pmid:13426103 |
| Fujita H and Matsuo I | Type I lipid photo-oxidation by the nonsteroidal anti-inflammatory drug suprofen: a possible key to its photosensitivity. | 1992-1993 Oct | Photodermatol Photoimmunol Photomed | pmid:1342189 |
| VILLALBA GOMEZ GM | [Squalene index]. | 1956 May-Aug | Rev Sanid Asist Soc | pmid:13379961 |
| DITURI F et al. | Terpenoid intermediates in the biosynthesis of cholesterol. | 1956 | J. Biol. Chem. | pmid:13345809 |
| Murakoshi M et al. | Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis. | 1992 | Int. J. Cancer | pmid:1334056 |
| SQUALENE and cholesterol synthesis in the human skin. | 1956 | Nutr. Rev. | pmid:13309889 | |
| DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
| RABINOWITZ JL et al. | Branched chain acids in the biosynthesis of squalene and cholesterol. | 1955 | Fed. Proc. | pmid:13262139 |
| Van Sickle WA et al. | Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. | 1992 | Lipids | pmid:1326069 |
| CORNFORTH JW and POPJAK G | Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. | 1954 | Biochem. J. | pmid:13208629 |
| SQUALENE, a precursor of cholesterol. | 1954 | Nutr. Rev. | pmid:13166142 | |
| EIDINOFF ML et al. | The biosynthesis of squalene from acetate in man. | 1954 | J. Clin. Invest. | pmid:13143078 |
| SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
| Bogan BW et al. | Alkanindiges illinoisensis gen. nov., sp. nov., an obligately hydrocarbonoclastic, aerobic squalane-degrading bacterium isolated from oilfield soils. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:13130023 |
| POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
| WHEATLEY VR | Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. | 1953 | Biochem. J. | pmid:13115346 |
| LANGDON RG and BLOCH K | The utilization of squalene in the biosynthesis of cholesterol. | 1953 | J. Biol. Chem. | pmid:13034768 |
| LANGDON RG and BLOCH K | The biosynthesis of squalene. | 1953 | J. Biol. Chem. | pmid:13034767 |
| NICOLAIDES N and ROTHMAN S | Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. | 1952 | J. Invest. Dermatol. | pmid:13023010 |
| Cooper MF et al. | Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. | 1976 | Br. J. Dermatol. | pmid:130160 |
| Pye RJ et al. | Skin surface lipid composition in rosacea. | 1976 | Br. J. Dermatol. | pmid:130159 |
| DALE J | Dehydrogenation of squalene with N-bromosuccinimide. | 1952 | Arch. Biochem. Biophys. | pmid:13008464 |
| Catalán CA et al. | A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. | 2003 | Phytochemistry | pmid:12943786 |
| Iorio AM et al. | Antibody responses and HIV-1 viral load in HIV-1-seropositive subjects immunised with either the MF59-adjuvanted influenza vaccine or a conventional non-adjuvanted subunit vaccine during highly active antiretroviral therapy. | 2003 | Vaccine | pmid:12922092 |
| Podda A and Del Giudice G | MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. | 2003 | Expert Rev Vaccines | pmid:12899571 |
| Satoh M et al. | Induction of lupus autoantibodies by adjuvants. | 2003 | J. Autoimmun. | pmid:12892730 |
| Zhang L et al. | Proopiomelanocortin peptides and sebogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12851311 |
| Rontani JF et al. | Production of a polyunsaturated isoprenoid wax ester during aerobic metabolism of squalene by Marinobacter squalenivorans sp. nov. | 2003 | Appl. Environ. Microbiol. | pmid:12839795 |
| Miettinen TA and Gylling H | Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. | 2003 | Atherosclerosis | pmid:12801618 |
| Madani KA | Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. | 2003 | Nutr. Rev. | pmid:12795450 |
| Ekanayake Mudiyanselage S et al. | Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo. | 2003 | J. Invest. Dermatol. | pmid:12787115 |
| Rocco F et al. | Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases. | 2003 | Lipids | pmid:12784859 |
| Chiba K et al. | Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784064 |
| Lu HT et al. | Preparative separation and purification of squalene from the microalga Thraustochytrium ATCC 26185 by high-speed counter-current chromatography. | 2003 | J Chromatogr A | pmid:12779217 |
| Ahrens EH | Sterol balance in hyperlipidemic patients after dietary exchange of carbohydrate for fat. | 1976 | J. Lipid Res. | pmid:1270936 |
| Hendler RW et al. | Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity. | 2003 | Eur. J. Biochem. | pmid:12709050 |
| Banzhoff A et al. | A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis. | 2003 May-Jun | Gerontology | pmid:12679609 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Luan Z et al. | Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663370 |
| Souto ML et al. | The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12657259 |
| Stephenson I et al. | Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. | 2003 | Vaccine | pmid:12639491 |
| Righetti M et al. | The in vitro metabolism of mevalonate by sterol and non-sterol pathways. | 1976 | J. Biol. Chem. | pmid:1262340 |
| Ketomäki A et al. | Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. | 2003 | Pediatr. Res. | pmid:12612218 |
| Ballou WR et al. | Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. | 2003 | J. Infect. Dis. | pmid:12599085 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Liu GC et al. | Measurement of squalene in human tissues and plasma: validation and application. | 1976 | J. Lipid Res. | pmid:1255019 |
| Khallouki F et al. | Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. | 2003 | Eur. J. Cancer Prev. | pmid:12548113 |
| Kushwaha SC and Kates M | Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. | 1976 | Can. J. Biochem. | pmid:1252986 |
| Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |
| Wiss O | Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252233 |
| Wiss O | Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. | 1976 | Biochem. Biophys. Res. Commun. | pmid:1252232 |
| Flores-Sánchez IJ et al. | Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. | 2002 | Plant Cell Physiol. | pmid:12514247 |
| Lee KT et al. | Structure of three new terpenoids, spiciformisins a and b, and monocyclosqualene, isolated from the herbs of Ligularia fischeri var. spiciformis and cytotoxicity. | 2002 | Arch. Pharm. Res. | pmid:12510832 |
| Strauss JS et al. | Skin lipids and acne. | 1975 | Annu. Rev. Med. | pmid:125065 |
| Dembitsky VM and Srebnik M | Variability of hydrocarbon and fatty acid components in cultures of the filamentous cyanobacterium Scytonema sp. isolated from microbial community "black cover" of limestone walls in Jerusalem. | 2002 | Biochemistry Mosc. | pmid:12495426 |
| Clouse SD | Brassinosteroids. Plant counterparts to animal steroid hormones? | 2002 | Vitam. Horm. | pmid:12481548 |
| Ostlund RE et al. | Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. | 2002 | Nutr. Rev. | pmid:12462517 |
| Hauss T et al. | Squalane is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier. | 2002 | Biochim. Biophys. Acta | pmid:12460672 |
| Zhang Z et al. | Effect of squalene and shark liver oil on serum cholesterol level in hamsters. | 2002 | Int J Food Sci Nutr | pmid:12396466 |
| Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
| Quang DN et al. | Concentriols B, C and D, three squalene-type triterpenoids from the ascomycete Daldinia concentrica. | 2002 | Phytochemistry | pmid:12359521 |
| Ley JP et al. | 3,4-Dihydroxymandelic acid, a noradrenalin metabolite with powerful antioxidative potential. | 2002 | J. Agric. Food Chem. | pmid:12358456 |
| Bernier UR et al. | Chemical analysis of human skin emanations: comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae). | 2002 | J. Am. Mosq. Control Assoc. | pmid:12322940 |