| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemorrhagic Septicemia, Viral | D031941 | 1 associated lipids |
| Persian Gulf Syndrome | D018923 | 1 associated lipids |
| Steatorrhea | D045602 | 2 associated lipids |
| Fasciitis | D005208 | 2 associated lipids |
| Ossification, Heterotopic | D009999 | 2 associated lipids |
| Pneumonia, Lipid | D011017 | 2 associated lipids |
| Exostoses, Multiple Hereditary | D005097 | 3 associated lipids |
| Gallbladder Diseases | D005705 | 3 associated lipids |
| Parvoviridae Infections | D010322 | 4 associated lipids |
| Simian Acquired Immunodeficiency Syndrome | D016097 | 4 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang W et al. | Feeding with supplemental squalene enhances the productive performance in boars. | 2008 | Anim. Reprod. Sci. | pmid:18164149 |
| Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-omaezakianol. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19248063 |
| Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-intricatetraol. | 2007 | Angew. Chem. Int. Ed. Engl. | pmid:17191285 |
| Cornforth JW | Olefin alkylation in biosynthesis. | 1968 | Angew. Chem. Int. Ed. Engl. | pmid:4976264 |
| Tong R and McDonald FE | Mimicking biosynthesis: total synthesis of the triterpene natural product abudinol B from a squalene-like precursor. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18459096 |
| RodrÃguez-López J et al. | Epoxide-opening cascades triggered by a Nicholas reaction: total synthesis of teurilene. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23436322 |
| Ernst J et al. | The crystal structure of squalene. | 1976 | Angew. Chem. Int. Ed. Engl. | pmid:827944 |
| Hoshino T et al. | Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15593147 |
| Giacometti J | Determination of aliphatic alcohols, squalene, alpha-tocopherol and sterols in olive oils: direct method involving gas chromatography of the unsaponifiable fraction following silylation. | 2001 | Analyst | pmid:11340981 |
| Young TE and Maggs RJ | The use of a moving wire detector system for the study of liquid chromatographic columns. | 1967 May-Jun | Anal. Chim. Acta | pmid:6045413 |
| Mountfort KA et al. | Identification of oxidation products of squalene in solution and in latent fingerprints by ESI-MS and LC/APCI-MS. | 2007 | Anal. Chem. | pmid:17343365 |
| BROOKS SC and GODEFROI VC | QUANITITATIVE COLLECTION OF MICRO AMOUNTS OF STEROIDS FROM GAS-LIQUID CHROMATOGRAPHY. | 1964 | Anal. Biochem. | pmid:14134426 |
| Grieveson LA et al. | A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene. | 1997 | Anal. Biochem. | pmid:9324936 |
| Taylor RF and Ikawa M | Gas chromatography of carotenoids. | 1971 | Anal. Biochem. | pmid:5130948 |
| Toh TH et al. | Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry. | 2001 | Anal. Biochem. | pmid:11141305 |
| ROTHBLAT GH et al. | A quantitative colorimetric assay for squalene. | 1962 | Anal. Biochem. | pmid:14494417 |
| Ikekawa N et al. | Determination of morphine in urine by gas chromatography. | 1969 | Anal. Biochem. | pmid:5781407 |
| Tait RM | Development of a radiometric spot-wash assay for squalene synthase. | 1992 | Anal. Biochem. | pmid:1416027 |
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
| Ruiz-Aragón J et al. | [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature]. | 2013 | An Pediatr (Barc) | pmid:23490433 |
| Bachman D et al. | Effect of bacille Calmette-Guerin immunotherapy on feline sarcoma virus-induced neoplasms in the cat. | 1982 | Am. J. Vet. Res. | pmid:6280529 |
| Hoffman SL et al. | Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. | 1994 | Am. J. Trop. Med. Hyg. | pmid:7985753 |
| Carlson BC et al. | The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats. | 2000 | Am. J. Pathol. | pmid:10854227 |
| Falcone DJ et al. | Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. | 1980 | Am. J. Pathol. | pmid:7361865 |
| Heikkinen T et al. | Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. | 2012 | Am. J. Obstet. Gynecol. | pmid:22939717 |
| Kanaji N et al. | Positron emission tomography-positive squalene-induced lipoid pneumonia confirmed by gas chromatography-mass spectrometry of bronchoalveolar lavage fluid. | 2008 | Am. J. Med. Sci. | pmid:18414072 |
| Villa M et al. | Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. | 2013 | Am. J. Epidemiol. | pmid:23863759 |
| Mannino S et al. | Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy. | 2012 | Am. J. Epidemiol. | pmid:22940713 |
| Skowronski DM et al. | Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". | 2013 | Am. J. Epidemiol. | pmid:23436898 |
| Newmark HL | Is oleic acid or squalene the important preventive agent? | 2000 | Am. J. Clin. Nutr. | pmid:10919949 |
| Downing DT et al. | Changes in skin surface lipid composition induced by severe caloric restriction in man. | 1972 | Am. J. Clin. Nutr. | pmid:5010536 |
| Miettinen TA and Vanhanen H | Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. | 1994 | Am. J. Clin. Nutr. | pmid:8310985 |
| Strauss JS et al. | Surface lipid composition in children with protein-calorie malnutrition. | 1978 | Am. J. Clin. Nutr. | pmid:414616 |
| Miettinen TA et al. | Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism. | 1987 | Am. Heart J. | pmid:3812207 |
| DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
| Kelly GS | Squalene and its potential clinical uses. | 1999 | Altern Med Rev | pmid:9988781 |
| Waterman E and Lockwood B | Active components and clinical applications of olive oil. | 2007 | Altern Med Rev | pmid:18069902 |
| Keefer MC et al. | Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8744579 |
| Ohkawa S et al. | Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. | 1994 | AIDS Res. Hum. Retroviruses | pmid:8179961 |
| Vajdy M et al. | Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. | 2004 | AIDS Res. Hum. Retroviruses | pmid:15588349 |
| Kajaste-Rudnitski A et al. | Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals. | 2011 | AIDS | pmid:21150561 |
| Durier C et al. | Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults. | 2013 | AIDS | pmid:23018437 |
| Pregliasco F et al. | Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly. | 2001 | Aging (Milano) | pmid:11292151 |
| Beck FW and Whitehouse MW | Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. | 1976 | Agents Actions | pmid:822699 |
| Kim SK and Karadeniz F | Biological importance and applications of squalene and squalane. | 2012 | Adv. Food Nutr. Res. | pmid:22361190 |
| Villee CA et al. | The regulation of the biosynthesis of sterols and steroids in the placenta. | 1966 | Adv. Enzyme Regul. | pmid:4862939 |
| Reddy LH and Couvreur P | Squalene: A natural triterpene for use in disease management and therapy. | 2009 | Adv. Drug Deliv. Rev. | pmid:19804806 |
| Haralampidis K et al. | Biosynthesis of triterpenoid saponins in plants. | 2002 | Adv. Biochem. Eng. Biotechnol. | pmid:11783842 |
| Yasuda Y et al. | Comparison of half and full doses of an MF59-adjuvanted cell culture-derived A/H1N1v vaccine in Japanese children. | 2010 | Adv Ther | pmid:20586002 |
| Caron J et al. | Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene. | 2013 | Adv Healthc Mater | pmid:23213041 |
| KROENING F | [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. | 1959 | Acta Unio Int Contra Cancrum | pmid:13848508 |
| Edgren B and Hellström K | Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits. | 1972 | Acta Physiol. Scand. | pmid:4640173 |
| Ismail AA et al. | Interrelation between thyroid hormones and essential fatty acids. | 1966 | Acta Physiol Acad Sci Hung | pmid:5953398 |
| Arffmann E and Glavind J | Studies by the newt test on carcinogenic properties of rats. | 1967 | Acta Pathol Microbiol Scand | pmid:6050372 |
| Zadák Z et al. | Polyunsaturated fatty acids, phytosterols and cholesterol metabolism in the Mediterranean diet. | 2006 | Acta Medica (Hradec Kralove) | pmid:16696439 |
| van Leusden HA et al. | Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. | 1971 | Acta Endocrinol. | pmid:5108099 |
| Cunliffe WJ et al. | An explanation fro chloracne -- an industrial hazard. | 1975 | Acta Derm. Venereol. | pmid:50695 |
| Cotterill JA et al. | Variation in skin surface lipid composition and sebum excretion rate with time. | 1973 | Acta Derm. Venereol. | pmid:4127454 |
| Liu CI et al. | Structural insights into the catalytic mechanism of human squalene synthase. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531458 |
| Mullakhanbhai MF and Francis GW | Bacterial lipids. 1. Lipid constituents of a moderately halophilic bacterium. | 1972 | Acta Chem Scand | pmid:5049648 |
| Schubert K and Schumann W | [On the biosynthesis of sterines]. | 1967 | Acta Biol. Med. Ger. | pmid:5593407 |
| Arias JL et al. | Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. | 2011 | ACS Nano | pmid:21275408 |
| Maksimenko A et al. | Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. | 2014 | ACS Nano | pmid:24555414 |
| Sémiramoth N et al. | Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections. | 2012 | ACS Nano | pmid:22482704 |
| Jawaid AM et al. | Shape-controlled colloidal synthesis of rock-salt lead selenide nanocrystals. | 2011 | ACS Nano | pmid:21770427 |
| Fox CB et al. | Immunomodulatory and physical effects of phospholipid composition in vaccine adjuvant emulsions. | 2012 | AAPS PharmSciTech | pmid:22415641 |