| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsuo I et al. | Mechanism of skin surface lipid peroxidation. | 1983 | Curr. Probl. Dermatol. | pmid:6197240 |
| Brown AJ et al. | Cholesterol precursors: more than mere markers of biosynthesis. | 2014 | Curr. Opin. Lipidol. | pmid:24378747 |
| Fitzky BU et al. | Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism. | 1999 | Curr. Opin. Lipidol. | pmid:10327280 |
| Lambrecht BN et al. | Mechanism of action of clinically approved adjuvants. | 2009 | Curr. Opin. Immunol. | pmid:19246182 |
| Kostyuk VA et al. | Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers. | 2013 | Curr. Med. Chem. | pmid:23210792 |
| Albers-Jackson B et al. | Incorporation of 14C acetate into the sterols of rabbit lens in organ culture. | 1982-1983 | Curr. Eye Res. | pmid:7184713 |
| Bhilwade HN et al. | Squalene as novel food factor. | 2010 | Curr Pharm Biotechnol | pmid:20874681 |
| Cattel L and Ceruti M | Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme. | 1998 | Crit. Rev. Biochem. Mol. Biol. | pmid:9827705 |
| Visioli F and Galli C | Biological properties of olive oil phytochemicals. | 2002 | Crit Rev Food Sci Nutr | pmid:12058980 |
| Vishnubhatla S et al. | Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and wax. | 2012 | Cont Lens Anterior Eye | pmid:22906863 |
| Teshima S and Kanazawa A | Biosynthesis of sterols in abalone, Haliotis gurneri, and mussel, Mytilus edulis. | 1974 | Comp. Biochem. Physiol., B | pmid:4452229 |
| Frayha GJ | Synthesis of certain cholesterol precursors by hydatid protoscoleces of Echinococcus granulosus and cysticerci of Taenia hydatigena. | 1974 | Comp. Biochem. Physiol., B | pmid:4416028 |
| Silva CJ et al. | Biosynthetic studies of marine lipids. 35. The demonstration of de novo sterol biosynthesis in sponges using radiolabeled isoprenoid precursors. | 1991 | Comp. Biochem. Physiol., B | pmid:1790671 |
| Teshima SI and Kanazawa A | Biosynthesis of sterols in a starfish, Laiaster leachii. | 1975 | Comp. Biochem. Physiol., B | pmid:1183195 |
| Voogt PA et al. | What about squalene in the earthworm Lumbricus terrestris? | 1975 | Comp. Biochem. Physiol., B | pmid:1122731 |
| Phleger CF et al. | Pressure effect on squalene-2,3-oxide cyclization in fish. | 1973 | Comp. Biochem. Physiol., B | pmid:4719990 |
| Anderson DG | Gorgosterol biosynthesis: localization of squalene formation in the zooxanthellar component of various gorgonians. | 1985 | Comp. Biochem. Physiol., B | pmid:2861942 |
| Edkins E and Hansen IA | Wax esters secreted by the uropygial glands of some Australian waterfowl, including the magpie goose. | 1972 | Comp. Biochem. Physiol., B | pmid:5075378 |
| Wells JW | Steroids in the pineal gland of the domestic fowl (Gallus domesticus): cholesterol and its biosynthesis. | 1971 | Comp. Biochem. Physiol., B | pmid:5133342 |
| Silva CJ and Djerassi C | Biosynthetic studies of marine lipids 36. The origin of common sterol side chains in eleven sponges using [3-3H]-squalene. | 1992 Jan-Feb | Comp. Biochem. Physiol., B | pmid:1499273 |
| Phleger CF et al. | Membrane biosynthesis in swimbladders of deep sea fishes Coryphaenoides acrolepis and Antimora rostrata. | 1977 | Comp. Biochem. Physiol., B | pmid:830467 |
| Arce V et al. | The in vivo incorporation of acetate into different non-saponifiable lipids by neonatal chick tissues. | 1984 | Comp. Biochem. Physiol., B | pmid:6478791 |
| Frayha GJ | A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). | 1968 | Comp. Biochem. Physiol. | pmid:5710286 |
| VAN DEN OORD A | THE ABSENCE OF CHOLESTEROL SYNTHESIS IN THE CRAB, CANCER PAGURUS L. | 1964 | Comp. Biochem. Physiol. | pmid:14246359 |
| Blondin GA et al. | The biosynthesis of squalene and sterols in fish. | 1966 | Comp. Biochem. Physiol. | pmid:4380202 |
| Frayha GJ and Fairbairn D | Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda). | 1969 | Comp. Biochem. Physiol. | pmid:4306773 |
| Lewis DJ et al. | Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine. | 2003 | Commun Dis Public Health | pmid:15067859 |
| Fox CB et al. | Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions. | 2008 | Colloids Surf B Biointerfaces | pmid:18440205 |
| Berglund J et al. | Safety, immunogenicity, and antibody persistence following an investigational Streptococcus pneumoniae and Haemophilus influenzae triple-protein vaccine in a phase 1 randomized controlled study in healthy adults. | 2014 | Clin. Vaccine Immunol. | pmid:24173029 |
| Fragapane E et al. | A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly. | 2010 | Clin. Vaccine Immunol. | pmid:20810680 |
| Del Giudice G et al. | Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene. | 2006 | Clin. Vaccine Immunol. | pmid:16960112 |
| Cheong HJ et al. | Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine. | 2011 | Clin. Vaccine Immunol. | pmid:21715575 |
| Viganò A et al. | Long-term immunogenicity after one and two doses of a monovalent MF59-adjuvanted A/H1N1 Influenza virus vaccine coadministered with the seasonal 2009-2010 nonadjuvanted Influenza virus vaccine in HIV-infected children, adolescents, and young adults in a randomized controlled trial. | 2011 | Clin. Vaccine Immunol. | pmid:21795458 |
| Song JY et al. | Comparison of the long-term immunogenicity of two pandemic influenza A/H1N1 2009 vaccines, the MF59-adjuvanted and unadjuvanted vaccines, in adults. | 2012 | Clin. Vaccine Immunol. | pmid:22379067 |
| Huijskens E et al. | Immunogenicity, boostability, and sustainability of the immune response after vaccination against Influenza A virus (H1N1) 2009 in a healthy population. | 2011 | Clin. Vaccine Immunol. | pmid:21795459 |
| Fox CB et al. | Effects on immunogenicity by formulations of emulsion-based adjuvants for malaria vaccines. | 2012 | Clin. Vaccine Immunol. | pmid:22896687 |
| Durando P et al. | Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults. | 2008 | Clin. Vaccine Immunol. | pmid:18003811 |
| Bihari I et al. | Assessment of antigen-specific and cross-reactive antibody responses to an MF59-adjuvanted A/H5N1 prepandemic influenza vaccine in adult and elderly subjects. | 2012 | Clin. Vaccine Immunol. | pmid:23081815 |
| Lopez P et al. | Combined administration of MF59-adjuvanted A/H5N1 prepandemic and seasonal influenza vaccines: long-term antibody persistence and robust booster responses 1 year after a one-dose priming schedule. | 2013 | Clin. Vaccine Immunol. | pmid:23536690 |
| Rajaratnam RA et al. | Impaired postprandial clearance of squalene and apolipoprotein B-48 in post-menopausal women with coronary artery disease. | 1999 | Clin. Sci. | pmid:10409473 |
| Kudchodkar BJ et al. | Mechanisms of hypolipidemic action of nicotinic acid. | 1978 | Clin. Pharmacol. Ther. | pmid:688728 |
| O'Hagan DT et al. | MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans: what did we learn during its development? | 2007 | Clin. Pharmacol. Ther. | pmid:17971820 |
| Kawakami T et al. | Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. | 1997 | Clin. Orthop. Relat. Res. | pmid:9137198 |
| Hoschler K et al. | Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children aged <3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later. | 2014 | Clin. Infect. Dis. | pmid:24149079 |
| Manuel O et al. | Humoral response to the influenza A H1N1/09 monovalent AS03-adjuvanted vaccine in immunocompromised patients. | 2011 | Clin. Infect. Dis. | pmid:21288852 |
| Atmar RL et al. | Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations. | 2006 | Clin. Infect. Dis. | pmid:17029131 |
| Cunningham CK et al. | Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women. | 2001 | Clin. Infect. Dis. | pmid:11229849 |
| Bate J et al. | Immunogenicity of pandemic (H1N1) 2009 vaccine in children with cancer in the United Kingdom. | 2010 | Clin. Infect. Dis. | pmid:21067352 |
| Son J et al. | Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients. | 2013 | Clin. Exp. Nephrol. | pmid:22990301 |
| Milanetti F et al. | Safety and immunogenicity of co-administered MF59-adjuvanted 2009 pandemic and plain 2009-10 seasonal influenza vaccines in rheumatoid arthritis patients on biologicals. | 2014 | Clin. Exp. Immunol. | pmid:24666311 |
| Holm BC et al. | Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. | 2004 | Clin. Exp. Immunol. | pmid:15196244 |
| Holm BC et al. | The arthritogenic adjuvant squalene does not accumulate in joints, but gives rise to pathogenic cells in both draining and non-draining lymph nodes. | 2002 | Clin. Exp. Immunol. | pmid:11966758 |
| Cho S et al. | High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects. | 2009 | Clin. Exp. Dermatol. | pmid:19522983 |
| Wysocki SJ et al. | Simultaneous assessment of fetal lung maturity and sebaceous gland function by gas chromatography. | 1984 | Clin. Chim. Acta | pmid:6705230 |
| Yamanishi Y et al. | Serum squalene levels in hepatobiliary diseases. | 1978 | Clin. Chim. Acta | pmid:679482 |
| Hallikainen M et al. | Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption. | 2006 | Clin. Chim. Acta | pmid:16814761 |
| Senthilkumar S et al. | Effect of squalene on cyclophosphamide-induced toxicity. | 2006 | Clin. Chim. Acta | pmid:16150433 |
| Simonen P et al. | Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes. | 2002 | Clin. Chim. Acta | pmid:11750274 |
| Ketomäki A et al. | Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis. | 2004 | Clin. Chim. Acta | pmid:15149875 |
| Hirayama C et al. | Serum cholesterol and squalene in hepatocellular carcinoma. | 1979 | Clin. Chim. Acta | pmid:216506 |
| Nikkilä K et al. | Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. | 1992 | Clin. Chim. Acta | pmid:1499139 |
| Messeri G et al. | Amniotic fluid squalene and gestational age. | 1982 | Clin. Chem. | pmid:7094305 |
| Beran J et al. | A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses. | 2010 | Clin Ther | pmid:21316535 |
| Nestel PJ and Kudchodkar B | Plasma squalene as an index of cholesterol synthesis. | 1975 | Clin Sci Mol Med | pmid:1204294 |
| Broeders NE et al. | Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study. | 2011 | Clin J Am Soc Nephrol | pmid:21921153 |
| Morimoto Y et al. | Asymmetric total synthesis of highly symmetric squalene-derived cytotoxic polyethers. | 2002 | Chirality | pmid:12112332 |
| Asnis DS et al. | Shark oil pneumonia. An overlooked entity. | 1993 | Chest | pmid:8449116 |
| Mouzdahir A et al. | Aerobic and anaerobic abiotic oxidation of squalene in the presence of hydroperoxides. | 2001 | Chemosphere | pmid:11482668 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Ito R et al. | Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L. | 2013 | Chemistry | pmid:24203491 |
| López P and MartÃn J | Potential chemosignals associated with male identity in the amphisbaenian Blanus cinereus. | 2009 | Chem. Senses | pmid:19406874 |
| Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
| Radwan SS and Mangold HK | Lipids in plant tissue cultures. V. Effect of environmental conditions on the lipids of Glycine soja and Brassica napus cultures. | 1975 | Chem. Phys. Lipids | pmid:1168102 |
| Stein RA and Mead JF | Small hydrocarbons formed by the peroxidation of squalene. | 1988 | Chem. Phys. Lipids | pmid:3342456 |
| Pogliani L et al. | An NMR and molecular mechanics study of squalene and squalene derivatives. | 1994 | Chem. Phys. Lipids | pmid:8013054 |
| Nurminen T et al. | Neutral lipids in the cells and cell envelope fractions of aerobic baker's yeast and anaerobic brewer's yeast. | 1975 | Chem. Phys. Lipids | pmid:1091369 |
| Kishi M et al. | Acid-catalyzed cyclization of squalene oxide. | 1967 | Chem. Pharm. Bull. | pmid:5583148 |
| Kawaki H | The interaction of monosubstituted benzenes with the stationary liquid in gas liquid chromatography. | 2004 | Chem. Pharm. Bull. | pmid:14758007 |
| Giner JL et al. | Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. | 2005 | Chem. Commun. (Camb.) | pmid:15959594 |
| Senthilkumar S et al. | Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. | 2006 | Chem. Biol. Interact. | pmid:16554041 |
| Richter E et al. | Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. | 1982 | Chem. Biol. Interact. | pmid:7083398 |
| Dang T and Prestwich GD | Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. | 2000 | Chem. Biol. | pmid:11048954 |
| Poralla K | Profound insights into squalene cyclization. | 2004 | Chem. Biol. | pmid:15112988 |
| Reinert DJ et al. | Conversion of squalene to the pentacarbocyclic hopene. | 2004 | Chem. Biol. | pmid:15113001 |
| Pannkuk EL et al. | Sebaceous lipid profiling of bat integumentary tissues: quantitative analysis of free Fatty acids, monoacylglycerides, squalene, and sterols. | 2013 | Chem. Biodivers. | pmid:24327437 |
| Wu TK et al. | Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships. | 2008 | Chem Rec | pmid:18956480 |
| Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
| Andersson HC | Disorders of post-squalene cholesterol biosynthesis leading to human dysmorphogenesis. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:11990452 |
| Dupuis M et al. | Dendritic cells internalize vaccine adjuvant after intramuscular injection. | 1998 | Cell. Immunol. | pmid:9637761 |
| Yoshino S and Yoshino J | Recruitment of pathogenic T cells to synovial tissues of rats injected intraarticularly with nonspecific agents. | 1994 | Cell. Immunol. | pmid:7522973 |
| Gill S et al. | Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase. | 2011 | Cell Metab. | pmid:21356516 |
| Seiki S and Frishman WH | Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. | 2009 Mar-Apr | Cardiol Rev | pmid:19367148 |
| Rao CV et al. | Chemopreventive effect of squalene on colon cancer. | 1998 | Carcinogenesis | pmid:9498278 |
| Sporn MB and Suh N | Chemoprevention of cancer. | 2000 | Carcinogenesis | pmid:10688873 |
| Smith TJ et al. | Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. | 1998 | Carcinogenesis | pmid:9600360 |
| Schulz S et al. | Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. | 1992 | Cancer Res. | pmid:1531325 |
| Ito M et al. | Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. | 1981 | Cancer Res. | pmid:7248952 |
| Yarkoni E and Rapp HJ | Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil. | 1979 | Cancer Res. | pmid:427795 |
| Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
| Masihi KN et al. | Modulation of natural killer cytotoxicity by muramyl dipeptide and trehalose dimycolate incorporated in squalane droplets. | 1987 | Cancer Immunol. Immunother. | pmid:3815418 |