| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michael-Jubeli R et al. | High-temperature gas chromatography-mass spectrometry for skin surface lipids profiling. | 2011 | J. Lipid Res. | pmid:20952798 |
| Nikkari T et al. | In vivo studies of sterol and squalene secretion by human skin. | 1974 | J. Lipid Res. | pmid:4430879 |
| Kelley MT et al. | Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. | 1969 | J. Lipid Res. | pmid:4305711 |
| Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
| HORLICK L and AVIGAN J | STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. | 1963 | J. Lipid Res. | pmid:14168146 |
| Strandberg TE et al. | Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. | 1990 | J. Lipid Res. | pmid:2246614 |
| GOODMAN DS and POPJAK G | Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes. | 1960 | J. Lipid Res. | pmid:13851061 |
| Gaskin F and Clayton RB | An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. | 1972 | J. Lipid Res. | pmid:4400581 |
| Nikkilä K et al. | Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. | 1996 | J. Lipid Res. | pmid:9017519 |
| Morand OH et al. | Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. | 1997 | J. Lipid Res. | pmid:9162756 |
| Weldon MK et al. | Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro. | 1998 | J. Lipid Res. | pmid:9741703 |
| Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
| Sloviter HA et al. | Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. | 1970 | J. Lipid Res. | pmid:5418482 |
| Gaylor JL et al. | Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. | 1966 | J. Lipid Res. | pmid:4290536 |
| Tornabene TG et al. | Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. | 1969 | J. Lipid Res. | pmid:5785002 |
| Relas H et al. | Fate of intravenously administered squalene and plant sterols in human subjects. | 2001 | J. Lipid Res. | pmid:11369807 |
| Ahrens EH | Sterol balance in hyperlipidemic patients after dietary exchange of carbohydrate for fat. | 1976 | J. Lipid Res. | pmid:1270936 |
| Gylling H and Miettinen TA | Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. | 2002 | J. Lipid Res. | pmid:12235179 |
| Nakagawa K et al. | Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin. | 2007 | J. Lipid Res. | pmid:17848584 |
| Morin RJ and Srikantaiah MV | In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol. | 1980 | J. Lipid Res. | pmid:7462811 |
| Helske S et al. | Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves. | 2008 | J. Lipid Res. | pmid:18398220 |
| Nagumo A et al. | Purification and characterization of recombinant squalene epoxidase. | 1995 | J. Lipid Res. | pmid:7595073 |
| Raouane M et al. | Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma. | 2011 | J. Med. Chem. | pmid:21561161 |
| Sen SE et al. | Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol. | 1990 | J. Med. Chem. | pmid:2342064 |
| Sen SE and Prestwich GD | Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase. | 1989 | J. Med. Chem. | pmid:2769687 |
| Ceruti M et al. | 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. | 1998 | J. Med. Chem. | pmid:9484504 |
| Stach D et al. | Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. | 1997 | J. Med. Chem. | pmid:9003518 |
| Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
| Barth MM et al. | Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. | 1996 | J. Med. Chem. | pmid:8691425 |
| Prashad M | Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. | 1993 | J. Med. Chem. | pmid:8496942 |
| Ceruti M et al. | 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. | 1992 | J. Med. Chem. | pmid:1501233 |
| Witiak DT et al. | Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. | 1969 | J. Med. Chem. | pmid:5793168 |
| Yoder JA et al. | Squalene: a naturally abundant mammalian skin secretion and long distance tick-attractant (Acari: Ixodidae). | 1999 | J. Med. Entomol. | pmid:10467784 |
| Morita T et al. | Inhibitory effect of a new mycotic agent, piritetrate on ergosterol biosynthesis in pathogenic fungi. | 1989 | J. Med. Vet. Mycol. | pmid:2666631 |
| Barrett-Bee KJ et al. | The mode of antifungal action of tolnaftate. | 1986 | J. Med. Vet. Mycol. | pmid:3522841 |
| Song JY et al. | Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine. | 2013 | J. Med. Virol. | pmid:23852684 |
| Hong WK et al. | Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. | 2013 | J. Microbiol. Biotechnol. | pmid:23676912 |
| Peri A and Serio M | Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. | 2008 | J. Mol. Endocrinol. | pmid:18768664 |
| Tornabene TG | Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. | 1978 | J. Mol. Evol. | pmid:691076 |
| Tornabene TG et al. | Phytanyl-glycerol ethers and squalenes in the archaebacterium Methanobacterium thermoautotrophicum. | 1978 | J. Mol. Evol. | pmid:691077 |
| Tornabene TG et al. | Squalenes, phytanes and other isoprenoids as major neutral lipids of methanogenic and thermoacidophilic "archaebacteria". | 1979 | J. Mol. Evol. | pmid:458874 |
| Gaber BP and Goodsell DS | The art of molecular graphics. Escape from flatland. | 2000 | J. Mol. Graph. Model. | pmid:10935209 |
| Asari F et al. | Turbinaric acid, a cytotoxic secosqualene carboxylic acid from the brown alga Turbinaria ornata. | 1989 Sep-Oct | J. Nat. Prod. | pmid:2607351 |
| Tran TV et al. | NF-κB inhibitors from Eurycoma longifolia. | 2014 | J. Nat. Prod. | pmid:24467387 |
| Noro JC et al. | Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. | 2008 | J. Nat. Prod. | pmid:18710283 |
| Abe I et al. | Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. | 2001 | J. Nat. Prod. | pmid:11520216 |
| Shamberger RJ | Inhibitory effect of vitamin A on carcinogenesis. | 1971 | J. Natl. Cancer Inst. | pmid:5157584 |
| Harro CD et al. | Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. | 2001 | J. Natl. Cancer Inst. | pmid:11181775 |
| Dennick RG et al. | Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. | 1974 | J. Neurochem. | pmid:4854410 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |