| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schulz JG et al. | HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | 2004 | J. Neurochem. | pmid:15030386 |
| Jones JP et al. | Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. | 1975 | J. Neurochem. | pmid:1110355 |
| Wagner-Recio M et al. | Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. | 1991 | J. Neurochem. | pmid:1940905 |
| Dennick RG et al. | Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. | 1974 | J. Neurochem. | pmid:4854410 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. | 1972 | J. Neurochem. | pmid:5009889 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Dennick RG and Dean PD | Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. | 1974 | J. Neurochem. | pmid:4277662 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
| Singh DK and Porter TD | Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. | 2006 | J. Nutr. | pmid:16484558 |
| HIGH EG and DAY HG | Effects of different amounts of lutein, squalene, phytol and related substances on the utilization of carotene and vitamin A for storage and growth in the rat. | 1951 | J. Nutr. | pmid:14851042 |
| Matschiner JT et al. | Effect of indigestible oils on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021812 |
| Matschiner JT et al. | Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021953 |
| Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
| Someya K et al. | The antioxidant effect of palm fruit carotene on skin lipid peroxidation in guinea pigs as estimated by chemiluminescence-HPLC method. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7844638 |
| Xiong Q et al. | Structure and reactivity of the dammarenyl cation: configurational transmission in triterpene synthesis. | 2005 | J. Org. Chem. | pmid:15989315 |
| Barrero AF et al. | Solid-phase selenium-catalyzed selective allylic chlorination of polyprenoids: facile syntheses of biologically active terpenoids. | 2006 | J. Org. Chem. | pmid:16839173 |
| Tong R et al. | Stereo- and regioselective synthesis of squalene tetraepoxide. | 2009 | J. Org. Chem. | pmid:19827774 |
| Koohang A et al. | Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. | 2010 | J. Org. Chem. | pmid:20545375 |
| Fontana A et al. | Evidence for the biosynthesis of squalene via the methylerythritol phosphate pathway in a Streptomyces sp. obtained from a marine sediment. | 2001 | J. Org. Chem. | pmid:11529755 |
| Barrero AF et al. | Mild TiIII- and Mn/ZrIV-catalytic reductive coupling of allylic halides: efficient synthesis of symmetric terpenes. | 2007 | J. Org. Chem. | pmid:17375959 |
| O'Hagan DT | Recent advances in vaccine adjuvants for systemic and mucosal administration. | 1998 | J. Pharm. Pharmacol. | pmid:9504429 |
| Rabiskova M et al. | The influence of surface properties on uptake of oil into complex coacervate microcapsules. | 1994 | J. Pharm. Pharmacol. | pmid:7815274 |
| Sajbidor J et al. | Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. | 1998 | J. Pharm. Pharmacol. | pmid:9600722 |
| Kamimura H et al. | Enhanced elimination of theophylline, phenobarbital and strychnine from the bodies of rats and mice by squalane treatment. | 1992 | J. Pharmacobio-dyn. | pmid:1527697 |
| Ohkuma T et al. | Intensification of host's immunity by squalene in sarcoma 180 bearing ICR mice. | 1983 | J. Pharmacobio-dyn. | pmid:6864440 |
| Reddy LH et al. | Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18258784 |
| MACKENNA RM et al. | Squalene and other hydrocarbons in human sebum. | 1955 | J. Physiol. (Lond.) | pmid:14354699 |
| Copado MA et al. | Fatty acids and squalene carried by alpha fetoprotein, and fetal and adult serum albumin from chicken. Comparison with these from mammals. | 1999 | J. Protein Chem. | pmid:10449039 |
| Ruiz-Gutiérrez V et al. | Detection of squalene in alpha-fetoprotein and fetal serum albumin from bovine. | 2001 | J. Protein Chem. | pmid:11330344 |
| Conner RL et al. | Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. | 1968 | J. Protozool. | pmid:5703082 |
| Deng X et al. | Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides. | 2002 | J. Reprod. Immunol. | pmid:11839398 |
| Garrett IR et al. | Ambivalent properties of gold drugs in adjuvant induced polyarthritis in rats. | 1985 | J. Rheumatol. | pmid:3937896 |
| Gutfinger T and Letan A | Quantitative changes in some unsaponifiable components of soya bean oil due to refining. | 1974 | J. Sci. Food Agric. | pmid:4473685 |
| van Leusden HA et al. | Lack of squalene and lanosterol synthesis by the perfused human placenta at term. | 1973 | J. Steroid Biochem. | pmid:4747979 |
| Caspi E et al. | Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid. | 1973 | J. Steroid Biochem. | pmid:4795867 |
| Bird S and Gower DB | Axillary 5 alpha-androst-16-en-3-one, cholesterol and squalene in men; preliminary evidence for 5 alpha-androst-16-en-3-one being a product of bacterial action. | 1982 | J. Steroid Biochem. | pmid:7176644 |
| Soloway AH and LeQuesne PW | Potential endogenous mutagens/carcinogens. | 1980 | J. Theor. Biol. | pmid:7464159 |
| van den Brand JM et al. | Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets. | 2011 | J. Virol. | pmid:21209108 |
| Chmielewska AM et al. | Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses. | 2014 | J. Virol. | pmid:24599994 |
| Stephenson I et al. | Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. | 2006 | J. Virol. | pmid:16641287 |
| Lin Y et al. | Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. | 2008 | J. Virol. | pmid:18508900 |
| Barnett SW et al. | Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant. | 2010 | J. Virol. | pmid:20392857 |
| Nesburn AB et al. | Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. | 1998 | J. Virol. | pmid:9733807 |
| Verschoor EJ et al. | Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. | 1999 | J. Virol. | pmid:10074183 |
| Stoskopf MK et al. | The impact of water temperature on core body temperature of North American river otters (Lutra canadensis) during simulated oil spill recovery washing protocols. | 1997 | J. Zoo Wildl. Med. | pmid:9523634 |
| Treanor JJ | Expanding the options for confronting pandemic influenza. | 2014 | JAMA | pmid:25291574 |
| Belshe RB et al. | Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291578 |
| Mulligan MJ et al. | Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291577 |
| Tabache F et al. | Acute polyarthritis after influenza A (H1N1) immunization. | 2011 | Joint Bone Spine | pmid:21444232 |