(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Nakagawa M et al. Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor. 1985 Jpn. J. Cancer Res. pmid:2408954
Yamaguchi T et al. Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system. 1985 Jpn. J. Cancer Res. pmid:3935620
Hwang SM et al. Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers. 2012 Jpn. J. Infect. Dis. pmid:22627298
Suzuki R Specific requirements of bile salts for absorption of cholesterol from the intestine. 1968 Keio J Med pmid:5715537
SCHOEN H and FAHSOLD W [Studies on the problem of resorption of squalene]. 1960 Klin. Wochenschr. pmid:14443328
Murakami S Isolation and analysis of squalene alcohols from rat preputial glands. 1973 Kobe J Med Sci pmid:4764042
Houston L et al. Response of guinea pigs to a vaccine containing a new adjuvant (SAF) and gram-negative bacteria. 1995 Lab. Anim. Sci. pmid:7752616
Robuccio JA et al. Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs. 1995 Lab. Anim. Sci. pmid:7474883
Budiarso IT Fish oil versus olive oil. 1990 Lancet pmid:1978131
Rickman LS et al. Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine. 1991 Lancet pmid:1673211
Nicholson KG et al. Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza. 2001 Lancet pmid:11425416
Griffiths PD et al. Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial. 2011 Lancet pmid:21481708
McElhaney JE et al. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. 2013 Lancet Infect Dis pmid:23518156
Ledgerwood JE AS03-adjuvanted influenza vaccine in elderly people. 2013 Lancet Infect Dis pmid:23518157
Ambike A et al. Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane. 2011 Langmuir pmid:21413743
Shrestha LK et al. Effect of water on foaming properties of diglycerol fatty acid ester-oil systems. 2007 Langmuir pmid:17523681
Arias JL et al. Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. 2008 Langmuir pmid:18540685
Gilmore SF et al. Role of squalene in the organization of monolayers derived from lipid extracts of Halobacterium salinarum. 2013 Langmuir pmid:23713788
Rasch MR et al. Chains, sheets, and droplets: assemblies of hydrophobic gold nanocrystals with saturated phosphatidylcholine lipid and squalene. 2012 Langmuir pmid:23033891
Lepeltier E et al. Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles. 2013 Langmuir pmid:24219056
Scallen TJ et al. Sterol carrier protein hypothesis: requirement for three substrate-specific soluble proteins in liver cholesterol biosynthesis. 1975 Life Sci. pmid:165341
Miettinen TA Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. 1969 Life Sci. pmid:5801489
Foti L et al. Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. 1969 Life Sci. pmid:5804653
Jones JP et al. Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: sterol formation. 1971 Life Sci. II pmid:5569686
Egwim PO and Kummerow FA In vitro hepatic cholesterogenesis in rats fed corn oil and fat-free diets. 1973 Life Sci. II pmid:4708203
Mercer EI Sterol biosynthesis inhibitors: their current status and modes of action. 1991 Lipids pmid:1779706
Yeo HC and Shibamoto T Formation of formaldehyde and malonaldehyde by photooxidation of squalene. 1992 Lipids pmid:1608304
Cattel L et al. The squalene-2,3-epoxide cyclase as a model for the development of new drugs. 1986 Lipids pmid:3515096
Kushwaha SC and Kates M Lipid composition of Neurospora crassa. 1976 Lipids pmid:136584
Bell FP Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate. 1976 Lipids pmid:994746
Johnson RC and Shah SN Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. 1976 Lipids pmid:994754
Lutsky BN et al. In vitro incorporation of 14C-acetate into lipids of hamster flank organ (costovertebral organ) sebaceous glands and epidermis. 1974 Lipids pmid:4810504
Brooks CJ et al. Lipids of human atheroma. VI. Hydrocarbons of the atheromatous plaque. 1970 Lipids pmid:5488810
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro. 1971 Lipids pmid:5574907
Cherayil GD et al. Abnormal lipid composition of fat tissue in human mesenteric panniculitis. 1981 Lipids pmid:6163941
Nes WR Role of sterols in membranes. 1974 Lipids pmid:4607429
Lees ND et al. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. 1995 Lipids pmid:7791529
Abe I and Prestwich GD Identification of the active site of vertebrate oxidosqualene cyclase. 1995 Lipids pmid:7791531
Tilvis RS and Miettinen TA Dietary squalene increases tissue sterols and fecal bile acids in the rat. 1983 Lipids pmid:6835033
Tilvis RS and Miettinen TA Absorption and metabolic fate of dietary 3H-squalene in the rat. 1983 Lipids pmid:6855483
Strandberg TE Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo. 1983 Lipids pmid:6621260
Balliano G et al. 3-Carboxy-4-nitrophenyl-dithio-1,1',2-trisnorsqualene: a site-directed inactivator of yeast oxidosqualene cyclase. 1993 Lipids pmid:8246689
Ceruti M et al. Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases. 2001 Lipids pmid:11485168
Viola F et al. Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase. 2000 Lipids pmid:10783007
Matthan NR et al. Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women. 2000 Lipids pmid:11026626
Nakagawa K et al. gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. 2010 Lipids pmid:20714817
Lau HL et al. Simultaneous quantification of free fatty acids, free sterols, squalene, and acylglycerol molecular species in palm oil by high-temperature gas chromatography--flame ionization detection. 2005 Lipids pmid:16094863
Choo YM et al. Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil. 2005 Lipids pmid:16028723
Oliaro-Bosso S et al. Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae. 2005 Lipids pmid:16477810
Borchman D et al. Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. 2013 Lipids pmid:24081494