(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Bell FP and Hubert EV Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. 1983 Lipids pmid:6633175
Johnson RC and Shah SN Hepatic cholesterol synthesis from mevalonate and squalwne in rats: effect of feeding cholesterol supplemented diet during weaning and following starvation. 1974 Lipids pmid:4444430
Strandberg TE et al. Effects of cholestyramine and squalene feeding on hepatic and serum plant sterols in the rat. 1989 Lipids pmid:2586228
Eilenberg H and Shechter I A possible regulatory role of squalene epoxidase in Chinese hamster ovary cells. 1984 Lipids pmid:6087072
Scallen TJ et al. Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder. 1971 Lipids pmid:4396848
Shah SN Regulation of hepatic cholesterol synthesis from mevalonate in suckling and weaned rats. 1973 Lipids pmid:4713377
McKean ML and Nes WR Delayed conversion of squalene to sterols during development of Pinus pinea seeds. 1977 Lipids pmid:853880
Nes WR Regulation of the sequencing in sterol biosynthesis. 1971 Lipids pmid:4997338
Koivisto PV and Miettinen TA Increased amounts of cholesterol precursors in lipoproteins after ileal exclusion. 1988 Lipids pmid:3200122
Cattel L et al. 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. 1995 Lipids pmid:7791532
Buttke TM et al. Regulation of squalene epoxidase activity by membrane fatty acid composition in yeast. 1988 Lipids pmid:3280941
Storm HM et al. Radioprotection of mice by dietary squalene. 1993 Lipids pmid:8355581
Milla P et al. 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. 1999 Lipids pmid:10478925
Mallory FB and Conner RL Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. 1971 Lipids pmid:4102490
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods. 1971 Lipids pmid:5559874
Porcellati G et al. Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. 1969 Lipids pmid:5785689
Van Sickle WA et al. Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. 1992 Lipids pmid:1326069
Morin RJ et al. Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities. 1982 Lipids pmid:7121212
Lewis RW Effect of alimentation on human serum squalene levels. 1976 Lipids pmid:180373
Lindholm JS and Downing DT Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. 1980 Lipids pmid:7219074
Bell FP and Hubert EV Stimulation of hepatic squalene and triglyceride synthesis by dimethylsulfoxide, in vitro. 1982 Lipids pmid:7162368
Rocco F et al. Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases. 2003 Lipids pmid:12784859
Srikantaiah MV et al. Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins. 1980 Lipids pmid:7432102
Peyronel D et al. Fatty acid and squalene compositions of Mediterranean Centrophorus SPP egg and liver oils in relation to age. 1984 Lipids pmid:6503627
Iannitti T and Palmieri B An update on the therapeutic role of alkylglycerols. 2010 Mar Drugs pmid:20948908
Hernández-García I et al. [Adverse events after administration of A/H1N1 vaccine to patients]. 2011 Med Clin (Barc) pmid:20199781
Saadatzadeh MR et al. Production of the mycelial phase of Malassezia in vitro. 2001 Med. Mycol. pmid:11798054
De Luca C and Valacchi G Surface lipids as multifunctional mediators of skin responses to environmental stimuli. 2010 Mediators Inflamm. pmid:20981292
Cuzzopoli M et al. Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. 1972 Metab. Clin. Exp. pmid:4641957
Gylling H et al. Hypolipidemic effect and mechanism of ketoconazole without and with cholestyramine in familial hypercholesterolemia. 1991 Metab. Clin. Exp. pmid:1984567
Relas H et al. Effect of stanol ester on postabsorptive squalene and retinyl palmitate. 2000 Metab. Clin. Exp. pmid:10778871
Salvioli G et al. Relationships between squalene and cholesterol in bile: effect of ursodeoxycholic acid administration in patients with radiolucent gallstones. 1984 Metab. Clin. Exp. pmid:6738365
Nakano M et al. 3-(4'-methyl-1'-naphthyl)propionic acid, 1',4'-endoperoxide for dioxygenation of squalene and for bacterial killing. 2000 Meth. Enzymol. pmid:10907513
Maes D et al. Noninvasive techniques for measuring oxidation products on the surface of human skin. 2000 Meth. Enzymol. pmid:10907548
Nishino T and Katsuki H Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase. 1985 Meth. Enzymol. pmid:3894880
Allison AC Squalene and squalane emulsions as adjuvants. 1999 Methods pmid:10525443
Colombatti M and Dosio F Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immunotoxins. 2001 Methods Mol. Biol. pmid:11217376
Huang MH et al. Enhancement of potent antibody and T-cell responses by a single-dose, novel nanoemulsion-formulated pandemic influenza vaccine. 2009 May-Jun Microbes Infect. pmid:19344782
Perzl M et al. Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. 1997 Microbiology (Reading, Engl.) pmid:9141686
Kerwin JL et al. Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. 1995 Microbiology (Reading, Engl.) pmid:7704271
HADORN H and JUNGKUNZ R [Further studies on squalene. 4]. 1950 Mitt Lebensmittelunters Hyg pmid:14806249
O'Hagan DT et al. Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. 1997 Mol Med Today pmid:9060004
Granados-Principal S et al. Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. 2012 Mol Nutr Food Res pmid:22648620
Vriet C et al. From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom. 2013 Mol Plant pmid:23761349
Lamb DC et al. Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. 2007 Mol. Biol. Evol. pmid:17567593
Popják G and Agnew WS Squalene synthetase. 1979 Mol. Cell. Biochem. pmid:41173
García-Román N et al. Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. 2001 Mol. Cell. Neurosci. pmid:11178870
Karst F and Lacroute F Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. 1977 Mol. Gen. Genet. pmid:200835
Allison AC and Byars NE Immunological adjuvants: desirable properties and side-effects. 1991 Mol. Immunol. pmid:1850114
Reddy LH et al. Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor. 2009 Sep-Oct Mol. Pharm. pmid:19634915