| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Scallen TJ et al. | Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. | 1968 | J. Biol. Chem. | pmid:4386511 |
| Mukherjee S and Bhose A | Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. | 1968 | Biochim. Biophys. Acta | pmid:5721032 |
| Threlfall DR et al. | Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. | 1968 | Biochem. J. | pmid:5721452 |
| Kelley MT et al. | Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. | 1969 | J. Lipid Res. | pmid:4305711 |
| Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
| Etemadi AH et al. | Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. | 1969 | Biochem. J. | pmid:4388240 |
| Popják G et al. | Biosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene. | 1969 | J. Biol. Chem. | pmid:4388617 |
| Fabre-Joneau M et al. | [The nature and distribution of hydrocarbons in the yeast Candida utilis]. | 1969 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4980247 |
| Frayha GJ and Fairbairn D | Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda). | 1969 | Comp. Biochem. Physiol. | pmid:4306773 |
| Suzue G and Porter JW | Enzymatic synthesis of lycopene from [4-14C]isopentenyl pyrophosphate. | 1969 | Biochim. Biophys. Acta | pmid:4308120 |
| Hayaishi O and Nozaki M | Nature and mechanisms of oxygenases. | 1969 | Science | pmid:4304952 |
| Akhtar M et al. | The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. | 1969 | Biochem. J. | pmid:5343788 |
| Gershbein LL and Singh EJ | Hydrocarbons of dogfish and cod livers and herring oil. | 1969 | J Am Oil Chem Soc | pmid:5345048 |
| Downing DT et al. | Variability in the chemical composition of human skin surface lipids. | 1969 | J. Invest. Dermatol. | pmid:5347411 |
| Partin JC and Schubert WK | Small intestinal mucosa in cholesterol ester storage disease. A light and electron microscope study. | 1969 | Gastroenterology | pmid:5348089 |
| Ramm PJ and Caspi E | The stereochemistry of tritium at carbon atoms 1, 7, and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. | 1969 | J. Biol. Chem. | pmid:5350956 |
| Lewis RW | Distribution of dietary squalene in a wandering Albatross, diomedea exultans. | 1969 | Nature | pmid:5358352 |
| Eneroth P et al. | Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium. | 1969 | Eur. J. Biochem. | pmid:5368336 |
| Schlösser E et al. | Sterols in species of Pythium. | 1969 | Arch Mikrobiol | pmid:5384630 |
| Yamamoto S et al. | Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. | 1969 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5257956 |
| Porcellati G and Giorgini D | The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. | 1969 | Biochem. Pharmacol. | pmid:5772592 |
| Goad LJ and Goodwin TW | Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. | 1969 | Eur. J. Biochem. | pmid:5780485 |
| Eppenberger U et al. | [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. | 1969 | Eur. J. Biochem. | pmid:5781271 |
| Ikekawa N et al. | Determination of morphine in urine by gas chromatography. | 1969 | Anal. Biochem. | pmid:5781407 |
| Akhtar M et al. | The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. | 1969 | Biochem. J. | pmid:5783476 |
| Tornabene TG et al. | Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. | 1969 | J. Lipid Res. | pmid:5785002 |
| Porcellati G et al. | Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. | 1969 | Lipids | pmid:5785689 |
| Boyd GS and Onajobi FD | Control of cholesterol biosynthesis by a plasma apo-lipoprotein. | 1969 | Nature | pmid:5789314 |
| Saxena SC and Zandee DI | Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. | 1969 | Arch. Int. Physiol. Biochim. | pmid:4188405 |
| Theiner M and Friedman L | Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. | 1969 | Proc. Soc. Exp. Biol. Med. | pmid:4183040 |
| Witiak DT et al. | Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. | 1969 | J. Med. Chem. | pmid:5793168 |
| Rees HH et al. | 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. | 1969 | Biochim. Biophys. Acta | pmid:5797101 |
| Walton TJ et al. | Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. | 1969 | Biochem. J. | pmid:5801311 |
| Miettinen TA | Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. | 1969 | Life Sci. | pmid:5801489 |
| Foti L et al. | Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. | 1969 | Life Sci. | pmid:5804653 |
| Yamamoto S and Bloch K | On the enzymes catalysing the transformation of squalene to lanosterol. | 1969 | Biochem. J. | pmid:5807185 |
| Higgins MJ and Kekwick RG | The role of malonyl-coenzyme A in isoprenoid biosynthesis. | 1969 | Biochem. J. | pmid:5807201 |
| St Clair RW et al. | Influence of atherosclerosis on the composition, synthesis, and esterification of lipids in aortas of squirrel monkeys (Saimiri sciureus). | 1969 Sep-Oct | J Atheroscler Res | pmid:4986077 |
| Yamamoto S and Bloch K | Enzymatic studies on the oxidative cyclizations of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4400141 |
| Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
| Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
| Morton RA | Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. | 1970 | Biochem. Soc. Symp. | pmid:4944436 |
| Van TAMELEN EE and Freed JH | Biochemical conversion of partially cyclized squalene 2,3-oxide types to the lanosterol system. Views on the normal enzymic cyclization process. | 1970 | J. Am. Chem. Soc. | pmid:4098774 |
| Popják G | Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4332649 |
| Yamamoto S | [Oxidative cyclization of squalene. Biosynthesis of sterols]. | 1970 | Tanpakushitsu Kakusan Koso | pmid:4912088 |
| Epstein WW and Rilling HC | Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. | 1970 | J. Biol. Chem. | pmid:4318477 |
| Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
| Robinson DR and West CA | Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. I. Identification of diterpene hydrocarbons formed from mevalonate. | 1970 | Biochemistry | pmid:5411208 |
| Ramasastry P et al. | Chemical composition of human skin surface lipids from birth to puberty. | 1970 | J. Invest. Dermatol. | pmid:5414607 |
| Sloviter HA et al. | Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. | 1970 | J. Lipid Res. | pmid:5418482 |
| Sargent JR et al. | Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. | 1970 | Biochem. J. | pmid:5420034 |
| Miettinen TA et al. | Serum squalene and methyl sterols. | 1970 | N. Engl. J. Med. | pmid:5470273 |
| Peter G et al. | [Gas chromatographic examinations of sebaceous gland lipids. I. Total lipid determination]. | 1970 | Arch Klin Exp Dermatol | pmid:5477881 |
| el-Ibrashy MT and Mansour MH | Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae. | 1970 | Experientia | pmid:5483755 |
| Pochi PE et al. | Sebaceous gland response in man to prolonged total caloric deprivation. | 1970 | J. Invest. Dermatol. | pmid:5483834 |
| Brooks CJ et al. | Lipids of human atheroma. VI. Hydrocarbons of the atheromatous plaque. | 1970 | Lipids | pmid:5488810 |
| Jayme M et al. | The nature of the hydrogen migrations in the cyclization of squalene oxide to lanosterol. | 1970 | J. Am. Chem. Soc. | pmid:5435274 |
| van Tamelen EE et al. | Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10'-norsqualene 2,3-oxide. | 1970 | J. Am. Chem. Soc. | pmid:5435278 |
| Phytochemistry: terpenoids for progress. | 1970 | Nature | pmid:5437511 | |
| Yamamoto S and Bloch K | Studies on squalene epoxidase of rat liver. | 1970 | J. Biol. Chem. | pmid:5438357 |
| Gallin JI et al. | Increased serum levels of seualene in patients with acute influenza. | 1970 | N. Engl. J. Med. | pmid:5442630 |
| Zander JM et al. | Tetrahymanol biosynthesis. Studies in vitro on squalene cyclization. | 1970 | J. Biol. Chem. | pmid:5442819 |
| Rahman R et al. | Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. | 1970 | J. Biol. Chem. | pmid:5445804 |
| Corey EJ and Yamamoto H | Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. | 1970 | Tetrahedron Lett. | pmid:5447652 |
| Kligman AM et al. | Comedogenicity of human sebum. | 1970 | Arch Dermatol | pmid:4247928 |
| Godinez MH et al. | The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. | 1970 | Arch. Biochem. Biophys. | pmid:5460184 |
| Caspi E and Mulheirn LJ | Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid. | 1970 | J. Am. Chem. Soc. | pmid:5460747 |
| Villee CA | Shark oil and medicine. | 1970 | N. Engl. J. Med. | pmid:5462581 |
| Stefanovich V and Kajiyama G | Squalene and cholestanol in normal rabbit aorta. | 1970 May-Jun | Atherosclerosis | pmid:5433085 |
| Habczyńska D et al. | [The effect of squalene and cholesterol on the histological picture of the periodontium in white rats]. | 1970 Oct-Nov | Czas Stomatol | pmid:5274119 |
| Scallen TJ et al. | Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder. | 1971 | Lipids | pmid:4396848 |
| Fiser RH et al. | Effects of acute infection on cholesterogenesis in the rhesus monkey. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:4399094 |
| Edmond J et al. | Presqualene alcohol. Further evidence on the structure of a C 30 precursor of squalene. | 1971 | J. Biol. Chem. | pmid:4399596 |
| Ferne M et al. | [Isolation and characterization of various membrane fractions type active in the synthesis in vitro of squalene and obtained from anergic tissue cultures of tobacco]. | 1971 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4997022 |
| Nes WR | Regulation of the sequencing in sterol biosynthesis. | 1971 | Lipids | pmid:4997338 |
| Anding C et al. | Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. | 1971 | Eur. J. Biochem. | pmid:5003307 |
| Dean PD | The cyclases of triterpene and sterol biosynthesis. | 1971 | Steroidologia | pmid:5004310 |
| Shamberger RJ | Inhibitory effect of vitamin A on carcinogenesis. | 1971 | J. Natl. Cancer Inst. | pmid:5157584 |
| Bird CW et al. | Steroids and squalene in Methylococcus capsulatus grown on methane. | 1971 | Nature | pmid:4929985 |
| Oesch F et al. | Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. | 1971 | Arch. Biochem. Biophys. | pmid:5117530 |
| Woods RA | Nystatin-resistant mutants of yeast: alterations in sterol content. | 1971 | J. Bacteriol. | pmid:5122815 |
| Popják G | Specificity of enzymes of sterol biosynthesis. | 1971 | Harvey Lect. | pmid:5123650 |
| Smith AG and Goad LJ | Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. | 1971 | Biochem. J. | pmid:5126917 |
| Ramsey RB et al. | Squalene-like isoprenoid hydrocarbons in bovine brain. | 1971 | J. Neurochem. | pmid:5129357 |
| Taylor RF and Ikawa M | Gas chromatography of carotenoids. | 1971 | Anal. Biochem. | pmid:5130948 |
| Boguslawski W and Zelewski L | Inhibition of cholesterol biosynthesis by the respiratory chain inhibitors in human placenta and in rat liver. | 1971 | Biochem. Pharmacol. | pmid:5132889 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Tamelen EE and Schwartz MA | Mechanism of presqualene pyrophosphate-squalene biosynthesis. | 1971 | J. Am. Chem. Soc. | pmid:4323745 |
| Rilling HC et al. | Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. | 1971 | J. Am. Chem. Soc. | pmid:4323746 |
| Mulheirn LJ and Caspi E | Mechanism of squalene cyclization. The biosynthesis of fusidic acid. | 1971 | J. Biol. Chem. | pmid:5553407 |
| Cotterill JA et al. | A semiquantitative method for the biochemical analysis of sebum. | 1971 | Br. J. Dermatol. | pmid:5557832 |
| Cunliffe WJ et al. | Variations in skin surface lipid composition with different sampling techniques. I. | 1971 | Br. J. Dermatol. | pmid:5557833 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods. | 1971 | Lipids | pmid:5559874 |
| Peter G et al. | [Gas-chromatography studies on sebaceous gland lipids. II. Composition of sebaceous gland lipids in various age groups]. | 1971 | Arch Dermatol Forsch | pmid:5560856 |
| Aaronson S | Inhibition of yeast multiplication by hypocholesteremic compounds and its annulment by lipids. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:5540639 |
| Corey EJ et al. | Conversion of des-6-methyl-2,3-oxidosqualene to 19-norlanosterol by 2,3-oxidosqualene-sterol cyclase. | 1971 | J. Am. Chem. Soc. | pmid:5548348 |
| Altman LJ et al. | Synthesis and conversion of presqualene alcohol to squalene. | 1971 | J. Am. Chem. Soc. | pmid:5550251 |
| Coates RM and Robinson WH | Stereoselective total synthesis of (plus or minus)-presqualene alcohol. | 1971 | J. Am. Chem. Soc. | pmid:5550252 |
| Jones JP et al. | Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: sterol formation. | 1971 | Life Sci. II | pmid:5569686 |
| Malhotra HC and Nes WR | The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol. | 1971 | J. Biol. Chem. | pmid:5570429 |