| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shabtay A et al. | The potential of Pleurotus-treated olive mill solid waste as cattle feed. | 2009 | Bioresour. Technol. | pmid:19683915 |
| Eroglu E and Melis A | Extracellular terpenoid hydrocarbon extraction and quantitation from the green microalgae Botryococcus braunii var. Showa. | 2010 | Bioresour. Technol. | pmid:20005092 |
| Hoshino T et al. | New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10635573 |
| Sato T et al. | Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9532806 |
| Kaya K et al. | Thraustochytrid Aurantiochytrium sp. 18W-13a accummulates high amounts of squalene. | 2011 | Biosci. Biotechnol. Biochem. | pmid:22056449 |
| Sato T et al. | Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056909 |
| Appelkvist EL | In vitro labeling of peroxisomal cholesterol with radioactive precursors. | 1987 | Biosci. Rep. | pmid:3449127 |
| Ghimire GP et al. | Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization. | 2009 | Biotechnol. Lett. | pmid:19116691 |
| Mironova VN and Chaialo PP | [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. | 1978 | Biull Eksp Biol Med | pmid:728610 |
| Yachnin S and Mannickarottu V | Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. | 1984 | Blood | pmid:6696995 |
| Gillard P et al. | Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. | 2014 | BMC Infect. Dis. | pmid:24628789 |
| Van Damme P et al. | Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. | 2010 | BMC Infect. Dis. | pmid:20504306 |
| Guzmán Herrador BR et al. | Usefulness of health registries when estimating vaccine effectiveness during the influenza A(H1N1)pdm09 pandemic in Norway. | 2012 | BMC Infect. Dis. | pmid:22429643 |
| Langley JM et al. | A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine. | 2012 | BMC Infect. Dis. | pmid:23110320 |
| Waddington CS et al. | Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. | 2010 | BMJ | pmid:20508026 |
| Rubinstein F et al. | Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. | 2013 | BMJ | pmid:23381200 |
| Paroli E | [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. | 1964 | Boll. Soc. Ital. Biol. Sper. | pmid:5877121 |
| van der Cammen TJ et al. | Prevention of pressure sores. A comparison of new and old pressure sore treatments. | 1987 | Br J Clin Pract | pmid:3332839 |
| Wysocki SJ et al. | Amniotic fluid squalene and fetal maturity. | 1979 | Br J Obstet Gynaecol | pmid:508672 |
| Editorial: Drugs for gastric ulceration. | 1974 | Br Med J | pmid:4832233 | |
| Cunliffe WJ et al. | Tetracycline and acne vulgaris: a clinical and laboratory investigation. | 1973 | Br Med J | pmid:4271323 |
| Cotterill JA et al. | Further observations on the pathogenesis of acne. | 1972 | Br Med J | pmid:4262616 |
| Shin DH et al. | Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet. | 2004 | Br. J. Biomed. Sci. | pmid:15058737 |
| Dykes PJ et al. | Analysis of the non-ionic detergent-soluble lipids of human stratum corneum. | 1984 | Br. J. Dermatol. | pmid:6696844 |
| Saint-Leger D et al. | A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation. | 1986 | Br. J. Dermatol. | pmid:2941049 |
| Saint-Leger D et al. | A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. | 1986 | Br. J. Dermatol. | pmid:2941050 |
| Dogliotti M et al. | Nutritional influences of pellagra on sebum composition. | 1977 | Br. J. Dermatol. | pmid:889695 |
| Cotterill JA et al. | Age and sex variation in skin surface lipid composition and sebum excretion rate. | 1972 | Br. J. Dermatol. | pmid:5077864 |
| Williams M et al. | The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. | 1973 | Br. J. Dermatol. | pmid:4270005 |
| Cotterill JA et al. | Sebum excretion rate and biochemistry in patients with acne vulgaris treated by oral fenfluramine. | 1971 | Br. J. Dermatol. | pmid:4255130 |
| Cotterill JA et al. | The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris. | 1971 | Br. J. Dermatol. | pmid:4255131 |
| Summerly R and Woodbury S | The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland. | 1971 | Br. J. Dermatol. | pmid:4257140 |
| Cuncliffe WJ et al. | Skin surface lipids in acne. | 1971 | Br. J. Dermatol. | pmid:4257142 |
| Cotterill JA et al. | Variations in skin surface lipid composition and sebum excretion rate with different sampling techniques. II. | 1972 | Br. J. Dermatol. | pmid:4260102 |
| Cotterill JA et al. | A semiquantitative method for the biochemical analysis of sebum. | 1971 | Br. J. Dermatol. | pmid:5557832 |
| Cunliffe WJ et al. | Variations in skin surface lipid composition with different sampling techniques. I. | 1971 | Br. J. Dermatol. | pmid:5557833 |
| Pye RJ et al. | Skin surface lipid composition in rosacea. | 1976 | Br. J. Dermatol. | pmid:130159 |
| Cooper MF et al. | Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. | 1976 | Br. J. Dermatol. | pmid:130160 |
| Mills OH et al. | Enhancement of comedogenic substances by ultraviolet radiation. | 1978 | Br. J. Dermatol. | pmid:147099 |
| Laitinen K et al. | Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. | 2009 | Br. J. Nutr. | pmid:19017423 |
| Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
| Toews AD et al. | Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. | 1997 | Brain Res. Mol. Brain Res. | pmid:9387870 |
| Albro PW and Fishbein L | Intestinal absorption of polychlorinated biphenyls in rats. | 1972 | Bull Environ Contam Toxicol | pmid:4630020 |
| Farrington JW et al. | Intercalibration of analyses of recently biosynthesized hydrocarbons and petroleum hydrocarbons in marine lipids. | 1973 | Bull Environ Contam Toxicol | pmid:4753263 |
| Bell FP | Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. | 1980 | Bull Environ Contam Toxicol | pmid:7357111 |
| Couvreur P | ["Squalenoylation": a new approach to the design of anticancer and antiviral nanomedicines]. | 2009 | Bull. Acad. Natl. Med. | pmid:19883017 |
| GOSSELIN L and DUVIVIER J | [BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE]. | 1965 | Bull. Soc. Chim. Biol. | pmid:14337120 |
| Socaciu C et al. | In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:8521075 |
| NUSBAUM-CASSUTO E and VILLOUTREIX J | [DEMONSTRATION OF LYCOPERSENE IN HIGHER PLANTS]. | 1965 | C. R. Hebd. Seances Acad. Sci. | pmid:14287016 |
| WOLFF RE and GODEFROY N | [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537384 |
| WOLFF RE and PICHAT L | [Synthesis of 11,14-C14-squalene]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537435 |
| Anding C et al. | [Comparative cyclization of 2,3 epoxide of methylene-22-dihydro-22-squalene in cell-free systems extracted from animal and higher plant tissues]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4632903 |
| Ferne M et al. | [Isolation and characterization of various membrane fractions type active in the synthesis in vitro of squalene and obtained from anergic tissue cultures of tobacco]. | 1971 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4997022 |
| Fabre-Joneau M et al. | [The nature and distribution of hydrocarbons in the yeast Candida utilis]. | 1969 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4980247 |
| Benveniste P et al. | [Biosynthesis of squalene with the help of microsomes originating from the tissue of tobacco cultivated in vitro]. | 1967 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4967365 |
| Tulliez J et al. | [The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism]. | 1975 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:807414 |
| LUPIEN PJ et al. | EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. | 1963 | Can J Biochem Physiol | pmid:14083981 |
| Kushwaha SC and Kates M | Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. | 1976 | Can. J. Biochem. | pmid:1252986 |
| Kushwaha SC and Kates M | Effect of glycerol on carotenogenesis in the extreme halophile, Halobacterium cutirubrum. | 1979 | Can. J. Microbiol. | pmid:540254 |
| Kushwaha SC and Kates M | Studies of the biosynthesis of C50 carotenoids in Halobacterium cutirubrum. | 1979 | Can. J. Microbiol. | pmid:540255 |
| Safe S and Caldwell J | The effect of growth environment on the chloroform-methanol and alkali-extractable cell wall and cytoplasm lipid levels of Mucor rouxii. | 1975 | Can. J. Microbiol. | pmid:1116039 |
| Domnas A et al. | Squalene metabolism in two species of Lagenidium. | 1994 | Can. J. Microbiol. | pmid:8076247 |
| Kushwaha SC et al. | Pigments and isoprenoid compounds in extremely and moderately halophilic bacteria. | 1974 | Can. J. Microbiol. | pmid:4822788 |
| Merdinger E et al. | Composition of lipids in extracts of Pullularia pullulans. | 1968 | Can. J. Microbiol. | pmid:5693067 |
| Wielgosz GJ and Armstrong DT | Effects of prolactin, progesterone, and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat. | 1978 | Can. J. Physiol. Pharmacol. | pmid:638868 |
| Newmark HL | Squalene, olive oil, and cancer risk: a review and hypothesis. | 1997 | Cancer Epidemiol. Biomarkers Prev. | pmid:9419410 |
| Masihi KN et al. | Modulation of natural killer cytotoxicity by muramyl dipeptide and trehalose dimycolate incorporated in squalane droplets. | 1987 | Cancer Immunol. Immunother. | pmid:3815418 |
| Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
| Schulz S et al. | Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. | 1992 | Cancer Res. | pmid:1531325 |
| Ito M et al. | Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. | 1981 | Cancer Res. | pmid:7248952 |
| Yarkoni E and Rapp HJ | Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil. | 1979 | Cancer Res. | pmid:427795 |
| Rao CV et al. | Chemopreventive effect of squalene on colon cancer. | 1998 | Carcinogenesis | pmid:9498278 |
| Sporn MB and Suh N | Chemoprevention of cancer. | 2000 | Carcinogenesis | pmid:10688873 |
| Smith TJ et al. | Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. | 1998 | Carcinogenesis | pmid:9600360 |
| Seiki S and Frishman WH | Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. | 2009 Mar-Apr | Cardiol Rev | pmid:19367148 |
| Gill S et al. | Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase. | 2011 | Cell Metab. | pmid:21356516 |
| Dupuis M et al. | Dendritic cells internalize vaccine adjuvant after intramuscular injection. | 1998 | Cell. Immunol. | pmid:9637761 |
| Yoshino S and Yoshino J | Recruitment of pathogenic T cells to synovial tissues of rats injected intraarticularly with nonspecific agents. | 1994 | Cell. Immunol. | pmid:7522973 |
| Andersson HC | Disorders of post-squalene cholesterol biosynthesis leading to human dysmorphogenesis. | 2002 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:11990452 |
| Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
| Wu TK et al. | Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships. | 2008 | Chem Rec | pmid:18956480 |
| Pannkuk EL et al. | Sebaceous lipid profiling of bat integumentary tissues: quantitative analysis of free Fatty acids, monoacylglycerides, squalene, and sterols. | 2013 | Chem. Biodivers. | pmid:24327437 |
| Dang T and Prestwich GD | Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. | 2000 | Chem. Biol. | pmid:11048954 |
| Poralla K | Profound insights into squalene cyclization. | 2004 | Chem. Biol. | pmid:15112988 |
| Reinert DJ et al. | Conversion of squalene to the pentacarbocyclic hopene. | 2004 | Chem. Biol. | pmid:15113001 |
| Senthilkumar S et al. | Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. | 2006 | Chem. Biol. Interact. | pmid:16554041 |
| Richter E et al. | Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. | 1982 | Chem. Biol. Interact. | pmid:7083398 |
| Giner JL et al. | Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. | 2005 | Chem. Commun. (Camb.) | pmid:15959594 |
| Kishi M et al. | Acid-catalyzed cyclization of squalene oxide. | 1967 | Chem. Pharm. Bull. | pmid:5583148 |
| Kawaki H | The interaction of monosubstituted benzenes with the stationary liquid in gas liquid chromatography. | 2004 | Chem. Pharm. Bull. | pmid:14758007 |
| Radwan SS and Mangold HK | Lipids in plant tissue cultures. V. Effect of environmental conditions on the lipids of Glycine soja and Brassica napus cultures. | 1975 | Chem. Phys. Lipids | pmid:1168102 |
| Stein RA and Mead JF | Small hydrocarbons formed by the peroxidation of squalene. | 1988 | Chem. Phys. Lipids | pmid:3342456 |
| Pogliani L et al. | An NMR and molecular mechanics study of squalene and squalene derivatives. | 1994 | Chem. Phys. Lipids | pmid:8013054 |
| Nurminen T et al. | Neutral lipids in the cells and cell envelope fractions of aerobic baker's yeast and anaerobic brewer's yeast. | 1975 | Chem. Phys. Lipids | pmid:1091369 |
| López P and MartÃn J | Potential chemosignals associated with male identity in the amphisbaenian Blanus cinereus. | 2009 | Chem. Senses | pmid:19406874 |
| Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Ito R et al. | Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L. | 2013 | Chemistry | pmid:24203491 |
| Mouzdahir A et al. | Aerobic and anaerobic abiotic oxidation of squalene in the presence of hydroperoxides. | 2001 | Chemosphere | pmid:11482668 |
| Asnis DS et al. | Shark oil pneumonia. An overlooked entity. | 1993 | Chest | pmid:8449116 |