| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sotiroudis TG and Kyrtopoulos SA | Anticarcinogenic compounds of olive oil and related biomarkers. | 2008 | Eur J Nutr | pmid:18458836 |
| Stella B et al. | Nonpolymeric nanoassemblies for ocular administration of acyclovir: pharmacokinetic evaluation in rabbits. | 2012 | Eur J Pharm Biopharm | pmid:22008147 |
| Chen CC et al. | Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. | 2010 | Eur J Pharm Biopharm | pmid:20060469 |
| Bildstein L et al. | Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes. | 2011 | Eur J Pharm Biopharm | pmid:21784150 |
| Lee JS et al. | Exogenous lipoid pneumonia: high-resolution CT findings. | 1999 | Eur Radiol | pmid:10101652 |
| Ochs D et al. | Properties of purified squalene-hopene cyclase from Bacillus acidocaldarius. | 1990 | Eur. J. Biochem. | pmid:2253626 |
| Cornforth JW et al. | Substrate stereochemistry of 3-hydroxy-3-methylglutaryl-coenzyme A synthase. | 1974 | Eur. J. Biochem. | pmid:4597848 |
| Parks LW et al. | Sterol transmethylation during aerobic adaptation of yeast. | 1974 | Eur. J. Biochem. | pmid:4598750 |
| Kribii R et al. | Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. | 1997 | Eur. J. Biochem. | pmid:9363754 |
| Anding C et al. | Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. | 1971 | Eur. J. Biochem. | pmid:5003307 |
| Kushiro T et al. | Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. | 1998 | Eur. J. Biochem. | pmid:9746369 |
| Phillips GT and Ross FP | Stereochemistry of C-1,2-dehydrogenation during cholesterol degradation by Mycobacterium phlei. | 1974 | Eur. J. Biochem. | pmid:4838683 |
| Bouvier P et al. | Non-specific biosynthesis of gammacerane derivatives by a cell-free system from the protozoon Tetrahymena pyriformis. Conformations of squalene, (3S)-squalene epoxide and (3R)-squalene epoxide during the cyclization. | 1980 | Eur. J. Biochem. | pmid:6780347 |
| Rohmer M et al. | Non-specific lanosterol and hopanoid biosynthesis be a cell-free system from the bacterium Methylococcus capsulatus. | 1980 | Eur. J. Biochem. | pmid:6780348 |
| Eneroth P et al. | Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium. | 1969 | Eur. J. Biochem. | pmid:5368336 |
| Goad LJ and Goodwin TW | Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. | 1969 | Eur. J. Biochem. | pmid:5780485 |
| Eppenberger U et al. | [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. | 1969 | Eur. J. Biochem. | pmid:5781271 |
| Dada OA et al. | Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. | 1968 | Eur. J. Biochem. | pmid:5653765 |
| Rohmer M et al. | Non-specific biosynthesis of hopane triterpenes by a cell-free system from Acetobacter pasteurianum. | 1980 | Eur. J. Biochem. | pmid:7460938 |
| Moreau JP et al. | Biosynthesis of sterols by a yeast homogenate. Incorporation of mevalonic acid into cholesta-5,7,24-trien-3beta-ol and 5alpha-cholesta-7,24-dien-3beta-ol. | 1975 | Eur. J. Biochem. | pmid:1100393 |
| Hendler RW et al. | Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity. | 2003 | Eur. J. Biochem. | pmid:12709050 |
| Das B et al. | In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy. | 2003 | Eur. J. Cancer | pmid:14602142 |
| Khallouki F et al. | Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. | 2003 | Eur. J. Cancer Prev. | pmid:12548113 |
| Miettinen TA and Gylling H | Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. | 2003 | Eur. J. Clin. Invest. | pmid:14636301 |
| Miettinen TA | Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis. | 1980 | Eur. J. Clin. Invest. | pmid:6768564 |
| Gylling H et al. | Effects of acipimox and cholestyramine on serum lipoproteins, non-cholesterol sterols and cholesterol absorption and elimination. | 1989 | Eur. J. Clin. Pharmacol. | pmid:2792164 |
| Gloor M and Kohler H | A contribution to a new test method for dandruff-inhibiting and "keratolytic" action of drugs. | 1977 | Eur. J. Clin. Pharmacol. | pmid:880976 |
| Gasparini R et al. | Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects. | 2001 | Eur. J. Epidemiol. | pmid:11599686 |
| Tomasi M et al. | Strong mucosal adjuvanticity of cholera toxin within lipid particles of a new multiple emulsion delivery system for oral immunization. | 1997 | Eur. J. Immunol. | pmid:9368632 |
| Dupuis M et al. | Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis. | 2001 | Eur. J. Immunol. | pmid:11592066 |
| Lippi G et al. | Vaccination, squalene and anti-squalene antibodies: facts or fiction? | 2010 | Eur. J. Intern. Med. | pmid:20206873 |
| Sawada M et al. | Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. | 2001 | Eur. J. Pharmacol. | pmid:11716837 |
| Wepierre J et al. | Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. | 1968 | Eur. J. Pharmacol. | pmid:5654669 |
| Gonzalez R et al. | Studies of sterol synthesis, synthesis regulation and transport in cultured human kidney. | 1974 | Exp. Cell Res. | pmid:4841900 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Chiba K et al. | Skin roughness and wrinkle formation induced by repeated application of squalene-monohydroperoxide to the hairless mouse. | 1999 | Exp. Dermatol. | pmid:10597136 |
| Tachi M and Iwamori M | Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. | 2008 | Exp. Dermatol. | pmid:17979971 |
| Hayashi N et al. | Effect of sunlight exposure and aging on skin surface lipids and urate. | 2003 | Exp. Dermatol. | pmid:14756518 |
| Tiffany JM | Individual variations in human meibomian lipid composition. | 1978 | Exp. Eye Res. | pmid:710541 |
| Fliesler SJ et al. | Squalene is localized to the plasma membrane in bovine retinal rod outer segments. | 1997 | Exp. Eye Res. | pmid:9176062 |
| Cenedella RJ | Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. | 1997 | Exp. Eye Res. | pmid:9237866 |
| Fliesler SJ et al. | Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. | 1995 | Exp. Eye Res. | pmid:7720806 |
| Aguilera Y et al. | The protective role of squalene in alcohol damage in the chick embryo retina. | 2005 | Exp. Eye Res. | pmid:15781281 |
| Takeuchi N et al. | Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. | 1978 | Exp. Gerontol. | pmid:639893 |
| Bell FP | Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study. | 1976 | Exp. Mol. Pathol. | pmid:1001402 |
| Asa PB et al. | Antibodies to squalene in Gulf War syndrome. | 2000 | Exp. Mol. Pathol. | pmid:10640454 |
| Alving CR and Grabenstein JD | Re: Antibodies to squalene in Gulf War Syndrome. | 2000 | Exp. Mol. Pathol. | pmid:10816387 |
| Lofland HB et al. | Atherosclerosis in Cebus monkeys. II. Arterial metabolism. | 1968 | Exp. Mol. Pathol. | pmid:4969998 |
| Nicolosi RJ et al. | Lipid accumulation in muscular foci in White Carneau and Show Racer pigeon aortas. | 1972 | Exp. Mol. Pathol. | pmid:5043333 |
| St Clair RW et al. | Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. | 1968 | Exp. Mol. Pathol. | pmid:5647248 |
| Asa PB et al. | Antibodies to squalene in recipients of anthrax vaccine. | 2002 | Exp. Mol. Pathol. | pmid:12127050 |
| Gajkowska B et al. | The experimental squalene encephaloneuropathy in the rat. | 1999 | Exp. Toxicol. Pathol. | pmid:10048717 |
| Bose AK and Hungund BL | The role of glycine in the biosynthesis of steroids. | 1973 | Experientia | pmid:4582087 |
| Grob EC and Csupor L | [Information on the leaf lipids of Acer platanoides L. during autumn yellowing]. | 1967 | Experientia | pmid:6077859 |
| Ferezou JP et al. | [On the absence of biosynthesis of sterols and squalene in coelenterata (anthozoa), the sea anemone Calliactis parasitica]. | 1972 | Experientia | pmid:4401744 |
| Ferezou JP et al. | [The absence of sterol and squalene biosynthesis a coelenterata (anthozoa), the sea anemone Calliactis parasitica]. | 1972 | Experientia | pmid:4402545 |
| el-Ibrashy MT and Mansour MH | Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae. | 1970 | Experientia | pmid:5483755 |
| Gower DB et al. | Axillary 5 alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. | 1985 | Experientia | pmid:4043321 |
| Durando P et al. | MF59-adjuvanted vaccine: a safe and useful tool to enhance and broaden protection against seasonal influenza viruses in subjects at risk. | 2010 | Expert Opin Biol Ther | pmid:20218923 |
| Celia C et al. | Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity. | 2011 | Expert Opin Drug Deliv | pmid:22077480 |
| Smith TJ | Squalene: potential chemopreventive agent. | 2000 | Expert Opin Investig Drugs | pmid:11060781 |
| Vera-Lastra O et al. | Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum. | 2013 | Expert Rev Clin Immunol | pmid:23557271 |
| Podda A and Del Giudice G | MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. | 2003 | Expert Rev Vaccines | pmid:12899571 |
| Gasparini R et al. | Aflunov(®): a prepandemic influenza vaccine. | 2012 | Expert Rev Vaccines | pmid:22309663 |
| Puig-Barberà J et al. | MF59™-adjuvanted seasonal influenza vaccine in young children. | 2011 | Expert Rev Vaccines | pmid:22043952 |
| Garçon N et al. | Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion. | 2012 | Expert Rev Vaccines | pmid:22380826 |
| Rappuoli R | Vaccine adjuvants: the future is bright. Interview by Jenaid Rees. | 2013 | Expert Rev Vaccines | pmid:23829664 |
| Puig Barberà J and González Vidal D | MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. | 2007 | Expert Rev Vaccines | pmid:17931147 |
| O'Hagan DT | MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. | 2007 | Expert Rev Vaccines | pmid:17931151 |
| Fox CB and Haensler J | An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants. | 2013 | Expert Rev Vaccines | pmid:23885820 |
| O'Hagan DT et al. | The history of MF59(®) adjuvant: a phoenix that arose from the ashes. | 2013 | Expert Rev Vaccines | pmid:23256736 |
| Walker WT and Faust SN | Monovalent inactivated split-virion AS03-adjuvanted pandemic influenza A (H1N1) vaccine. | 2010 | Expert Rev Vaccines | pmid:21105775 |
| O'Hagan DT et al. | MF59 adjuvant: the best insurance against influenza strain diversity. | 2011 | Expert Rev Vaccines | pmid:21506643 |
| El Sahly H | MF59™ as a vaccine adjuvant: a review of safety and immunogenicity. | 2010 | Expert Rev Vaccines | pmid:20923265 |
| Viola F et al. | 22,23-Epoxy-2-aza-2,3-dihydrosqualene derivatives: potent new inhibitors of squalene 2,3-oxide-lanosterol cyclase. | 1990 | Farmaco | pmid:2282128 |
| Saenz MT et al. | Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil. | 1998 | Farmaco | pmid:9786644 |
| Cherkes AI and Klebanov BM | [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. | 1966 Nov-Dec | Farmakol Toksikol | pmid:6000378 |
| Ito R et al. | Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases. | 2013 | FEBS J. | pmid:23294602 |
| Ta MT et al. | Accumulation of squalene is associated with the clustering of lipid droplets. | 2012 | FEBS J. | pmid:23013491 |
| Astruc M et al. | The binding of squalene by human placental cytosol: role in conversion of squalene to lanosterol. | 1974 | FEBS Lett. | pmid:4426400 |
| Furubayashi M et al. | Directed evolution of squalene synthase for dehydrosqualene biosynthesis. | 2014 | FEBS Lett. | pmid:25093296 |
| Ryder NS et al. | Inhibition of fungal and mammalian sterol biosynthesis by 2-aza-2,3-dihydrosqualene. | 1986 | FEBS Lett. | pmid:3525224 |
| Nakano M et al. | Useful 1O2 (1delta g) generator, 3-(4'-methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO), for dioxygenation of squalence (a skin surface lipid) in an organic solvent and bacterial killing in aqueous medium. | 1998 | FEBS Lett. | pmid:9710240 |
| Balliano G et al. | Differential inhibition of fungal oxidosqualene cyclase by 6E and 6Z isomers of 2,3-epoxy-10-aza-10,11-dihydrosqualene. | 1993 | FEBS Lett. | pmid:8462686 |
| Dracheva S et al. | Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. | 1996 | FEBS Lett. | pmid:8612754 |
| Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
| Arthington-Skaggs BA et al. | Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. | 1996 | FEBS Lett. | pmid:8772195 |
| Garbuzov AG et al. | Presence of squalene in human aorta. | 1966 May-Jun | Fed Proc Transl Suppl | pmid:5222095 |
| Scallen TJ et al. | Proceedings: Sterol carrier protein hypothesis. | 1974 | Fed. Proc. | pmid:4827525 |
| RABINOWITZ JL et al. | Branched chain acids in the biosynthesis of squalene and cholesterol. | 1955 | Fed. Proc. | pmid:13262139 |
| Fukasawa LO et al. | Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. | 2004 | FEMS Immunol. Med. Microbiol. | pmid:15196569 |
| Kuchta T et al. | Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. | 1997 | FEMS Microbiol. Lett. | pmid:9163904 |
| Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
| Douka E et al. | Structural diversity of the triterpenic hydrocarbons from the bacterium Zymomonas mobilis: the signature of defective squalene cyclization by the squalene/hopene cyclase. | 2001 | FEMS Microbiol. Lett. | pmid:11377875 |
| Mantzouridou F and Tsimidou MZ | Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. | 2010 | FEMS Yeast Res. | pmid:20550581 |
| Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |
| Hosogaya N et al. | The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata. | 2013 | FEMS Yeast Res. | pmid:23496820 |
| Klesius PH et al. | The macrophage chemotactic activity of Streptococcus agalactiae and Streptococcus iniae extracellular products (ECP). | 2007 | Fish Shellfish Immunol. | pmid:17212985 |
| Koval'ova VA et al. | [Effects of natural antioxidants on the content of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ulceration]. | 2014 | Fiziol Zh | pmid:25007524 |
| Blagović B et al. | Lipid analysis of the plasma membrane and mitochondria of brewer's yeast. | 2005 | Folia Microbiol. (Praha) | pmid:15954530 |