| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Occupational | D009783 | 12 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michael-Jubeli R et al. | High-temperature gas chromatography-mass spectrometry for skin surface lipids profiling. | 2011 | J. Lipid Res. | pmid:20952798 |
| Nikkari T et al. | In vivo studies of sterol and squalene secretion by human skin. | 1974 | J. Lipid Res. | pmid:4430879 |
| MCCARTHY MJ et al. | COMPOSITION OF MOLECULAR DISTILLATES OF BUTTER OIL: ISOLATION AND IDENTIFICATION OF COMPONENTS OTHER THAN GLYCERIDES. | 1964 | J. Lipid Res. | pmid:14221107 |
| Kelley MT et al. | Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. | 1969 | J. Lipid Res. | pmid:4305711 |
| Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
| HORLICK L and AVIGAN J | STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. | 1963 | J. Lipid Res. | pmid:14168146 |
| Strandberg TE et al. | Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. | 1990 | J. Lipid Res. | pmid:2246614 |
| Liu GC et al. | Measurement of squalene in human tissues and plasma: validation and application. | 1976 | J. Lipid Res. | pmid:1255019 |
| Gaskin F and Clayton RB | An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. | 1972 | J. Lipid Res. | pmid:4400581 |
| Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
| Saudek CD et al. | Plasma squalene: lipoprotein distribution and kinetic analysis. | 1978 | J. Lipid Res. | pmid:712242 |
| Pedersen A et al. | An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. | 2000 | J. Lipid Res. | pmid:11108723 |
| Eisele B et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. | 1997 | J. Lipid Res. | pmid:9101437 |
| Björkhem I et al. | Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. | 1987 | J. Lipid Res. | pmid:3681138 |
| Morand OH et al. | Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. | 1997 | J. Lipid Res. | pmid:9162756 |
| Burki E et al. | Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein. | 1987 | J. Lipid Res. | pmid:3681144 |
| Vanhanen HT et al. | Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. | 1993 | J. Lipid Res. | pmid:8228636 |
| Gylling H et al. | Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study. | 2010 | J. Lipid Res. | pmid:20436182 |
| Raskin P and Siperstein MD | Mevalonate metabolism by renal tissue in vitro. | 1974 | J. Lipid Res. | pmid:4811213 |
| Mark M et al. | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820110 |
| Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
| Sloviter HA et al. | Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. | 1970 | J. Lipid Res. | pmid:5418482 |
| Gaylor JL et al. | Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis. | 1966 | J. Lipid Res. | pmid:4290536 |
| Fuks-Holmberg D and Bloch K | Intermembrane transfer of squalene promoted by supernatant protein factor. | 1983 | J. Lipid Res. | pmid:6854149 |
| Hata S et al. | Effect of detergents on sterol synthesis in a cell-free system of yeast. | 1982 | J. Lipid Res. | pmid:6752317 |
| Corcelli A et al. | Lipid-protein stoichiometries in a crystalline biological membrane: NMR quantitative analysis of the lipid extract of the purple membrane. | 2002 | J. Lipid Res. | pmid:11792732 |
| Tornabene TG et al. | Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. | 1969 | J. Lipid Res. | pmid:5785002 |
| Relas H et al. | Fate of intravenously administered squalene and plant sterols in human subjects. | 2001 | J. Lipid Res. | pmid:11369807 |
| Daly MM | Biosynthesis of squalene and sterols by rat aorta. | 1971 | J. Lipid Res. | pmid:5579265 |
| Miettinen TA | Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. | 1982 | J. Lipid Res. | pmid:7200504 |
| Camera E et al. | Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry. | 2010 | J. Lipid Res. | pmid:20719760 |
| Gylling H and Miettinen TA | Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. | 2002 | J. Lipid Res. | pmid:12235179 |
| Shechter I et al. | A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. | 1980 | J. Lipid Res. | pmid:7381322 |
| Morin RJ and Srikantaiah MV | In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol. | 1980 | J. Lipid Res. | pmid:7462811 |
| Helske S et al. | Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves. | 2008 | J. Lipid Res. | pmid:18398220 |
| Nagumo A et al. | Purification and characterization of recombinant squalene epoxidase. | 1995 | J. Lipid Res. | pmid:7595073 |
| Hamilton JA et al. | Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1. | 2000 | J. Leukoc. Biol. | pmid:10670584 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Ito M et al. | Stereographic and stereometric study of sebaceous gland hyperplasia in rabbit pinnas induced by topically applied substances. | 1991 | J. Invest. Dermatol. | pmid:2056196 |
| Puhvel SM and Sakamoto M | An in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. | 1977 | J. Invest. Dermatol. | pmid:143497 |
| GRIESEMER RD and THOMAS RW | LIPOGENESIS IN HUMAN SKIN. II. THE EFFECT OF PHYSICAL AND CHEMICAL FACTORS ON IN VITRO LIPOGENESIS FROM ACETATE. | 1963 | J. Invest. Dermatol. | pmid:14059599 |
| GRIESEMER RD and THOMAS RW | LIPOGENESIS IN HUMAN SKIN. III. VARIATION WITH BODY SITE. | 1963 | J. Invest. Dermatol. | pmid:14066602 |
| Bortz JT et al. | The origin of alkanes found in human skin surface lipids. | 1989 | J. Invest. Dermatol. | pmid:2584738 |
| Stewart ME et al. | Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. | 1984 | J. Invest. Dermatol. | pmid:6228612 |
| Thiele JJ et al. | Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. | 1999 | J. Invest. Dermatol. | pmid:10594744 |
| Nazzaro-Porro M et al. | Lipoxygenase activity of Pityrosporum in vitro and in vivo. | 1986 | J. Invest. Dermatol. | pmid:3088129 |
| Matsuo I et al. | Lipid peroxidative potency of photosensitized thiazide diuretics. | 1986 | J. Invest. Dermatol. | pmid:3772156 |
| Downing DT et al. | The time course of lipid formation in human sebaceous glands. | 1977 | J. Invest. Dermatol. | pmid:903669 |
| Ottaviani M et al. | Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. | 2006 | J. Invest. Dermatol. | pmid:16778793 |
| Morita T and Nozawa Y | Effects of antifungal agents on ergosterol biosynthesis in Candida albicans and Trichophyton mentagrophytes: differential inhibitory sites of naphthiomate and miconazole. | 1985 | J. Invest. Dermatol. | pmid:3902987 |
| NICOLAIDES N and ROTHMAN S | The site of sterol and squalene synthesis in the human skin. | 1955 | J. Invest. Dermatol. | pmid:14354270 |
| BOUGHTON B et al. | Some observations of the nature, origin and possible function of the squalene and other hydrocarbons of human sebum. | 1955 | J. Invest. Dermatol. | pmid:14354278 |
| Kellum RE et al. | Human sebaceous gland lipids: in vitro incubations with 14C-labelled compounds. | 1973 | J. Invest. Dermatol. | pmid:4684160 |
| NICOLAIDES N and ROTHMAN S | Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. | 1952 | J. Invest. Dermatol. | pmid:13023010 |
| Ramasastry P et al. | Chemical composition of human skin surface lipids from birth to puberty. | 1970 | J. Invest. Dermatol. | pmid:5414607 |
| Pochi PE et al. | Sebaceous gland response in man to prolonged total caloric deprivation. | 1970 | J. Invest. Dermatol. | pmid:5483834 |
| SOBEL H | Squalene in sebum and sebum-like materials. | 1949 | J. Invest. Dermatol. | pmid:15398762 |
| Downing DT et al. | Variability in the chemical composition of human skin surface lipids. | 1969 | J. Invest. Dermatol. | pmid:5347411 |
| Pelle E et al. | Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. | 2008 | J. Invest. Dermatol. | pmid:18007585 |
| Downing DT et al. | Estimation of sebum production rates in man by measurement of the squalene content of skin biopsies. | 1981 | J. Invest. Dermatol. | pmid:7276619 |
| Kellum RE | Short chain fatty acids (below C12) of human skin surface lipids. | 1967 | J. Invest. Dermatol. | pmid:6022603 |
| Ekanayake Mudiyanselage S et al. | Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo. | 2003 | J. Invest. Dermatol. | pmid:12787115 |
| Hsia SL et al. | Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. | 1966 | J. Invest. Dermatol. | pmid:5924299 |
| Kligman LH and Kligman AM | The effect on rhino mouse skin of agents which influence keratinization and exfoliation. | 1979 | J. Invest. Dermatol. | pmid:501133 |
| SOBEL H et al. | Determinations of squalene in sebum from the forehead of patients with skin cancer. | 1957 | J. Invest. Dermatol. | pmid:13491890 |
| Strauss JS et al. | The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. | 1980 | J. Invest. Dermatol. | pmid:6444323 |
| Gabutti G et al. | Safety and immunogenicity of conventional subunit and MF59-adjuvanted influenza vaccines in human immunodeficiency virus-1-seropositive patients. | 2005 Jul-Aug | J. Int. Med. Res. | pmid:16104444 |
| Goodfellow RD and Liu GC | Squalene metabolism in the larva of the fly, Sarcophaga bullata. | 1972 | J. Insect Physiol. | pmid:5009197 |
| Ballou WR et al. | Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. | 2003 | J. Infect. Dis. | pmid:12599085 |
| Lopez P et al. | Combined, concurrent, and sequential administration of seasonal influenza and MF59-adjuvanted A/H5N1 vaccines: a phase II randomized, controlled trial of immunogenicity and safety in healthy adults. | 2011 | J. Infect. Dis. | pmid:21606530 |
| Traquina P et al. | MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. | 1996 | J. Infect. Dis. | pmid:8940205 |
| Nichol KL and Treanor JJ | Vaccines for seasonal and pandemic influenza. | 2006 | J. Infect. Dis. | pmid:17163383 |
| McFarland EJ et al. | Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. | 2001 | J. Infect. Dis. | pmid:11679925 |
| Kahn JO et al. | Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers. | 1994 | J. Infect. Dis. | pmid:7963729 |
| Bernstein DI et al. | Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults. | 2002 | J. Infect. Dis. | pmid:11865427 |
| Ray R et al. | Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins. | 2010 | J. Infect. Dis. | pmid:20677942 |
| Andrews N et al. | Age-specific effectiveness of an oil-in-water adjuvanted pandemic (H1N1) 2009 vaccine against confirmed infection in high risk groups in England. | 2011 | J. Infect. Dis. | pmid:21148494 |
| Launay O et al. | Safety and immunogenicity of a monovalent 2009 influenza A/H1N1v vaccine adjuvanted with AS03A or unadjuvanted in HIV-infected adults: a randomized, controlled trial. | 2011 | J. Infect. Dis. | pmid:21628666 |
| Bernstein DI et al. | Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. | 2008 | J. Infect. Dis. | pmid:18260764 |
| Zhao RY et al. | Cloning and characterization of squalene synthase gene from Fusarium fujikuroi (Saw.) Wr. | 2010 | J. Ind. Microbiol. Biotechnol. | pmid:20585832 |
| Matyas GR et al. | Induction and detection of antibodies to squalene. | 2000 | J. Immunol. Methods | pmid:11042279 |
| Matyas GR et al. | Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and mice. | 2004 | J. Immunol. Methods | pmid:15087221 |
| Matyas GR et al. | Induction and detection of antibodies to squalene. II. Optimization of the assay for murine antibodies. | 2002 | J. Immunol. Methods | pmid:12165433 |
| Valensi JP et al. | Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. | 1994 | J. Immunol. | pmid:7930610 |
| Caproni E et al. | MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. | 2012 | J. Immunol. | pmid:22351935 |
| Seubert A et al. | The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. | 2008 | J. Immunol. | pmid:18390722 |
| Gylling H et al. | The metabolism of cholestanol in primary biliary cirrhosis. | 1996 | J. Hepatol. | pmid:8738731 |
| Relas H et al. | Postprandial retinyl palmitate and squalene metabolism is age dependent. | 2000 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:11078083 |
| Vajdy M et al. | Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. | 2006 | J. Gen. Virol. | pmid:16847121 |
| David MH and Kirsop BH | A correlation between oxygen requirements and the products of sterol synthesis in strains of Saccharomyces cerevisiae. | 1973 | J. Gen. Microbiol. | pmid:4584066 |
| Aaronson S and Fulco L | Effect of hypocholesteremic compounds on bacterial multiplication. | 1968 | J. Gen. Microbiol. | pmid:5640227 |
| Asano KG et al. | Chemical composition of fingerprints for gender determination. | 2002 | J. Forensic Sci. | pmid:12136987 |
| Weyermann C et al. | Initial results on the composition of fingerprints and its evolution as a function of time by GC/MS analysis. | 2011 | J. Forensic Sci. | pmid:20707835 |
| Soto G et al. | Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. | 2011 | J. Exp. Bot. | pmid:21908473 |
| Worsham DN et al. | Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. | 2003 | J. Eukaryot. Microbiol. | pmid:14736216 |
| Bhavnani BR | Oestrogen biosynthesis in the pregnant mare. | 1981 | J. Endocrinol. | pmid:6453917 |
| Ainsworth L and Nitchuk WM | Cholesterol biosynthesis by sheep foetal liver and placenta in vitro. | 1972 | J. Endocrinol. | pmid:5062219 |
| Sun Y et al. | A reproducible in-vivo model of lymphatic malformation in rats. | 2011 | J. Comp. Pathol. | pmid:21419420 |
| Pass RF | Development and evidence for efficacy of CMV glycoprotein B vaccine with MF59 adjuvant. | 2009 | J. Clin. Virol. | pmid:19647480 |