(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Banzhoff A et al. | MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. | 2009 | PLoS ONE | pmid:19197383 |
Surls J et al. | Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. | 2012 | PLoS ONE | pmid:22723880 |
Leszczynska A et al. | Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. | 2009 | PLoS ONE | pmid:20041128 |
Lai RP et al. | Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants. | 2012 | PLoS ONE | pmid:22509385 |
Marinaro M et al. | A caprine herpesvirus 1 vaccine adjuvanted with MF59â„¢ protects against vaginal infection and interferes with the establishment of latency in goats. | 2012 | PLoS ONE | pmid:22511971 |
Meyer K et al. | A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infection. | 2011 | PLoS ONE | pmid:21887300 |
Gefenaite G et al. | Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. | 2013 | PLoS ONE | pmid:23840413 |
Wijnans L et al. | Effectiveness of MF59â„¢ adjuvanted influenza A(H1N1)pdm09 vaccine in risk groups in the Netherlands. | 2013 | PLoS ONE | pmid:23646191 |
Bischoff AL et al. | Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. | 2013 | PLoS ONE | pmid:23637733 |
Henryk T et al. | [The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. | 2005 | Pol. Merkur. Lekarski | pmid:15997638 |
Lewkowicz N et al. | [Biological action and clinical application of shark liver oil]. | 2006 | Pol. Merkur. Lekarski | pmid:16875171 |
Sliwowski J | [Mechanisms of squalene cyclization to tetra- and pentacyclic triterpenes (author's transl)]. | 1974 | Postepy Biochem. | pmid:4849151 |
Wojciechowski ZA | [Protein activators of the biosynthesis and metabolism of cholesterol]. | 1986 | Postepy Biochem. | pmid:3550764 |
JACHYMCZYK W | [Biosynthesis of triterpenoid compounds]. | 1963 | Postepy Biochem. | pmid:13957182 |
Influenza vaccine with squalene adjuvant: new preparation. No better than available products. | 2004 | Prescrire Int | pmid:15599987 | |
Volkov GL et al. | [In vitro biosynthesis of cholesterol and its precursors in the osseous tissue of rats]. | 1976 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:1005362 |
Anisimov MM et al. | [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. | 1978 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:724665 |
Ellebedy AH et al. | Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21270336 |
Liu GC et al. | Measurement of cholesterol synthesis in man by isotope kinetics of squalene. | 1975 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1060141 |
Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
Maksimenko A et al. | A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24385587 |
Galli G et al. | Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19237568 |
Vono M et al. | The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24324152 |
Galli G et al. | Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19416838 |
Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
Mosca F et al. | Molecular and cellular signatures of human vaccine adjuvants. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18650390 |
Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
Stone KJ and Strominger JL | Inhibition of sterol biosynthesis by bacitracin. | 1972 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4338587 |
Niehaus TD et al. | Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21746901 |
Yamamoto S et al. | Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. | 1969 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5257956 |
Shibata N et al. | Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226224 |
Lin FY et al. | Mechanism of action and inhibition of dehydrosqualene synthase. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21098670 |
Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
Seubert A et al. | Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21690334 |
Babiychuk E et al. | Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18287026 |
Popják G et al. | Effects of 2,3-iminosqualene on cultured cells. | 1987 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:2894034 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379289 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379291 |
Cornforth J | Symmetry of squalene epoxidation in vivo. | 1977 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:22855 |
ALEXANDER GJ and ALEXANDER RB | INHIBITION OF CHOLESTEROL SYNTHESIS IN VIVO BY A CONVULSANT, METRAZOL. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14117448 |
BURGESS TL and WILSON JD | Studies on hormonal regulation of squalene synthesis in preputial gland and skin of the rat. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:14016990 |
GAYLOR JL | Anaerobic conversion of acetate to squalene by rat skin. | 1961 | Proc. Soc. Exp. Biol. Med. | pmid:13704081 |
Fiser RH et al. | Effects of acute infection on cholesterogenesis in the rhesus monkey. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:4399094 |
Beck FW and Whitehouse MW | I. Drug sensitivity of rat adjuvant arthritis, induced with "adjuvants" containing no mineral oil components. | 1974 | Proc. Soc. Exp. Biol. Med. | pmid:4841187 |
FLESCH P | Hair loss from squalene. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14844354 |
Theiner M and Friedman L | Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. | 1969 | Proc. Soc. Exp. Biol. Med. | pmid:4183040 |
Aaronson S | Inhibition of yeast multiplication by hypocholesteremic compounds and its annulment by lipids. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:5540639 |