(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ernst J et al. | The crystal structure of squalene. | 1976 | Angew. Chem. Int. Ed. Engl. | pmid:827944 |
Hoshino T et al. | Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15593147 |
Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-intricatetraol. | 2007 | Angew. Chem. Int. Ed. Engl. | pmid:17191285 |
Tong R and McDonald FE | Mimicking biosynthesis: total synthesis of the triterpene natural product abudinol B from a squalene-like precursor. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18459096 |
RodrÃguez-López J et al. | Epoxide-opening cascades triggered by a Nicholas reaction: total synthesis of teurilene. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23436322 |
Zhang W et al. | Feeding with supplemental squalene enhances the productive performance in boars. | 2008 | Anim. Reprod. Sci. | pmid:18164149 |
Wepierre J | [Impermeability of mouse skin to tritiated perhydrosqualene]. | 1967 Jul-Aug | Ann Pharm Fr | pmid:5618585 |
Montagnani S et al. | Autoimmune hemolytic anemia following MF59-adjuvanted influenza vaccine administration: a report of two cases. | 2011 | Ann Pharmacother | pmid:21189364 |
Cicchini T et al. | [The importance of man, mouse and rat skin surface lipid fractions on the "in vitro" penetration of "Schistosoma mansoni" cercariae (author's transl)]. | 1977 Sep-Oct | Ann Sclavo | pmid:616258 |
Bartfai E et al. | [Studies on the genotoxic effects of crude liver oils from 3 species of Mediterranean sharks by means of in vitro micronucleus test using human lymphocytes]. | 2000 Sep-Oct | Ann. Biol. Clin. (Paris) | pmid:11022102 |