(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
Morton RA | Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. | 1970 | Biochem. Soc. Symp. | pmid:4944436 |
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Epstein WW and Rilling HC | Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. | 1970 | J. Biol. Chem. | pmid:4318477 |
Rilling HC | Biosynthesis of presqualene pyrophosphate by liver microsomes. | 1970 | J. Lipid Res. | pmid:4322765 |
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Lewis RW | Distribution of dietary squalene in a wandering Albatross, diomedea exultans. | 1969 | Nature | pmid:5358352 |
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Schlösser E et al. | Sterols in species of Pythium. | 1969 | Arch Mikrobiol | pmid:5384630 |
Yamamoto S et al. | Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. | 1969 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5257956 |
Porcellati G and Giorgini D | The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. | 1969 | Biochem. Pharmacol. | pmid:5772592 |
Goad LJ and Goodwin TW | Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. | 1969 | Eur. J. Biochem. | pmid:5780485 |
Eppenberger U et al. | [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. | 1969 | Eur. J. Biochem. | pmid:5781271 |
Theiner M and Friedman L | Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. | 1969 | Proc. Soc. Exp. Biol. Med. | pmid:4183040 |
Witiak DT et al. | Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. | 1969 | J. Med. Chem. | pmid:5793168 |
Rees HH et al. | 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. | 1969 | Biochim. Biophys. Acta | pmid:5797101 |
Walton TJ et al. | Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. | 1969 | Biochem. J. | pmid:5801311 |
Miettinen TA | Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. | 1969 | Life Sci. | pmid:5801489 |
Foti L et al. | Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. | 1969 | Life Sci. | pmid:5804653 |