(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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SQUALENE and cholesterol synthesis in the human skin. | 1956 | Nutr. Rev. | pmid:13309889 | |
VILLALBA GOMEZ GM | [Squalene index]. | 1956 May-Aug | Rev Sanid Asist Soc | pmid:13379961 |
BOUGHTON B et al. | Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. | 1957 | Biochem. J. | pmid:13426103 |
HELLER JH et al. | Squalene content of various shark livers. | 1957 | Nature | pmid:13430738 |
TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
TCHEN TT and BLOCH K | On the mechanism of enzymatic cyclization of squalene. | 1957 | J. Biol. Chem. | pmid:13438882 |
SOBEL H et al. | Determinations of squalene in sebum from the forehead of patients with skin cancer. | 1957 | J. Invest. Dermatol. | pmid:13491890 |
DITURI F et al. | Precursors of squalene and cholesterol. | 1957 | J. Biol. Chem. | pmid:13502345 |
EIDINOFF ML et al. | Cholesterol biosynthesis: studies related to the metabolic role of squalene. | 1958 | J. Clin. Invest. | pmid:13539207 |
POPJAK G et al. | Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13546172 |