(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Koval'ova VA et al. | [Effects of natural antioxidants on the content of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ulceration]. | 2014 | Fiziol Zh | pmid:25007524 |
Liu CI et al. | Structural insights into the catalytic mechanism of human squalene synthase. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531458 |
Maksimenko A et al. | A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24385587 |
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Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
Gillard P et al. | Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. | 2014 | BMC Infect. Dis. | pmid:24628789 |
Tran TV et al. | NF-κB inhibitors from Eurycoma longifolia. | 2014 | J. Nat. Prod. | pmid:24467387 |
Vinay TN et al. | Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus). | 2014 | Vet. Immunol. Immunopathol. | pmid:23570990 |
Maksimenko A et al. | Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. | 2014 | ACS Nano | pmid:24555414 |
Chmielewska AM et al. | Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses. | 2014 | J. Virol. | pmid:24599994 |
Furubayashi M et al. | Directed evolution of squalene synthase for dehydrosqualene biosynthesis. | 2014 | FEBS Lett. | pmid:25093296 |
Brown AJ et al. | Cholesterol precursors: more than mere markers of biosynthesis. | 2014 | Curr. Opin. Lipidol. | pmid:24378747 |
Poder A et al. | An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. | 2014 | Vaccine | pmid:24252703 |