(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Scallen TJ et al. | Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. | 1968 | Biochem. Biophys. Res. Commun. | pmid:5653642 |
Markelova VF and Levachev MM | [Inclusion of C14-acetate in cholesterol and tissue squalene of rats in choline-protein deficiency]. | 1967 Nov-Dec | Vopr Pitan | pmid:5610866 |
Young TE and Maggs RJ | The use of a moving wire detector system for the study of liquid chromatographic columns. | 1967 May-Jun | Anal. Chim. Acta | pmid:6045413 |
Wepierre J | [Impermeability of mouse skin to tritiated perhydrosqualene]. | 1967 Jul-Aug | Ann Pharm Fr | pmid:5618585 |
Blumer M | Hydrocarbons in digestive tract and liver of a basking shark. | 1967 | Science | pmid:5609822 |
Rao KS and Olson RE | The effect of exogenous cholesterol on the synthesis in vivo of cholesterol, ubiquinone, and squalene in rat liver. | 1967 | Biochem. Biophys. Res. Commun. | pmid:6030977 |
Arffmann E and Glavind J | Studies by the newt test on carcinogenic properties of rats. | 1967 | Acta Pathol Microbiol Scand | pmid:6050372 |
Grob EC and Csupor L | [Information on the leaf lipids of Acer platanoides L. during autumn yellowing]. | 1967 | Experientia | pmid:6077859 |
Cain CE et al. | Hydrocarbons from human meninges and meningiomas. | 1967 | Biochim. Biophys. Acta | pmid:6078120 |
Graebe JE | Isoprenoid biosynthesis in a cell-free system from pea shoots. | 1967 | Science | pmid:4381746 |
Charlton JM et al. | Incorporation of 2-[14C]mevalonic acid into phytoene by isolated chloroplasts. | 1967 | Biochem. J. | pmid:4383323 |
Short RV | The synthesis and secretion of steroids by the corpus luteum. | 1967 | Arch Anat Microsc Morphol Exp | pmid:4973334 |
Johnson WS | Nonenzymic biogenetic-like olefinic cyclizations. | 1967 | Trans N Y Acad Sci | pmid:5237390 |
Benveniste P et al. | [Biosynthesis of squalene with the help of microsomes originating from the tissue of tobacco cultivated in vitro]. | 1967 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4967365 |
Nightingale MS et al. | Testicular sterols. VI. Incorporation of mevalonate into squalene and sterols by cell-free preparations of testicular tissue. | 1967 | J. Biol. Chem. | pmid:4290213 |
Stone KJ and Hemming FW | The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. | 1967 | Biochem. J. | pmid:4292001 |
Willett JD et al. | Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. | 1967 | J. Biol. Chem. | pmid:6061706 |
van Tamelen EE et al. | Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6064361 |
Kishi M et al. | Acid-catalyzed cyclization of squalene oxide. | 1967 | Chem. Pharm. Bull. | pmid:5583148 |
Voogt PA | Biosynthesis of 3-beta-sterols in a snail, Arion rufus L., from 1-14C-acetate. | 1967 | Arch. Int. Physiol. Biochim. | pmid:4167714 |
Schubert K and Schumann W | [On the biosynthesis of sterines]. | 1967 | Acta Biol. Med. Ger. | pmid:5593407 |
Corey EJ and Ortiz de Montellano PR | Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6042774 |
van Tamelen EE et al. | On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6042776 |
Corey EJ et al. | 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. | 1967 | J. Am. Chem. Soc. | pmid:6043808 |
Corey EJ and Gross SK | Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6046552 |
Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
Katsuki H and Bloch K | Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. | 1967 | J. Biol. Chem. | pmid:6016607 |
Kellum RE | Human sebaceous gland lipids. Analysis by thin-layer chromatography. | 1967 | Arch Dermatol | pmid:6019001 |
Matschiner JT et al. | Effect of indigestible oils on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021812 |
Matschiner JT et al. | Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. | 1967 | J. Nutr. | pmid:6021953 |
Kellum RE | Short chain fatty acids (below C12) of human skin surface lipids. | 1967 | J. Invest. Dermatol. | pmid:6022603 |
Frantz ID and Schroepfer GJ | Sterol biosynthesis. | 1967 | Annu. Rev. Biochem. | pmid:18257735 |
Dean PD et al. | A soluble 2,3-oxidosqualene sterol cyclase. | 1967 | J. Biol. Chem. | pmid:6027261 |
Cherkes AI and Klebanov BM | [Cholesterine synthesis as an object of the action of drugs. (Review of the literature)]. | 1966 Nov-Dec | Farmakol Toksikol | pmid:6000378 |
Garbuzov AG et al. | Presence of squalene in human aorta. | 1966 May-Jun | Fed Proc Transl Suppl | pmid:5222095 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379289 |
Cornforth JW et al. | Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. | 1966 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:4379291 |
Blondin GA et al. | The biosynthesis of squalene and sterols in fish. | 1966 | Comp. Biochem. Physiol. | pmid:4380202 |
Krishna G et al. | Enzymic conversion of farnesyl pyrophosphate to squalene. | 1966 | Arch. Biochem. Biophys. | pmid:4380977 |
Akhtar M et al. | The obligatory intermediacy of a cholesta-5,7-diene system in the hepatic biosynthesis of cholesterol. | 1966 | Biochem. J. | pmid:4381706 |
Cory EJ et al. | 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. | 1966 | J. Am. Chem. Soc. | pmid:5918046 |
Corey EJ and Russey WE | Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. | 1966 | J. Am. Chem. Soc. | pmid:5918047 |
Van Tamelen EE et al. | Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. | 1966 | J. Am. Chem. Soc. | pmid:5918048 |
Cmelik SH and Webster GD | Squalene in vernix caseosa from African neonates. | 1966 | Cent Afr J Med | pmid:5919884 |
Hsia SL et al. | Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. | 1966 | J. Invest. Dermatol. | pmid:5924299 |
Butterworth PH et al. | In vivo incorporation of [2-14-C]-mevalonate into dolichol of rabbit and pig liver. | 1966 | Arch. Biochem. Biophys. | pmid:5944963 |
Chesterton CJ | The subcellular site of cholesterol synthesis in rat liver. | 1966 | Biochem. Biophys. Res. Commun. | pmid:5971766 |
Brooks CJ et al. | Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. | 1966 | Biochim. Biophys. Acta | pmid:5973204 |
Van Tamelen EE et al. | Nonenzymic laboratory cyclization of squalene 2,3-oxide. | 1966 | J. Am. Chem. Soc. | pmid:5980879 |
Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |