HEXACOSANOIC ACID

HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with HEXACOSANOIC ACID?

HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Metabolic Diseases D008659 12 associated lipids
Adrenocortical Hyperfunction D000308 3 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Blepharospasm D001764 1 associated lipids
Iron Metabolism Disorders D019189 1 associated lipids
Tics D020323 1 associated lipids
Crush Syndrome D003444 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with HEXACOSANOIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with HEXACOSANOIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with HEXACOSANOIC ACID?

Knock-out

Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with HEXACOSANOIC ACID

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Authors Title Published Journal PubMed Link
Krause KH et al. [EMG and evoked potentials in adrenomyeloneuropathy]. 1985 EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb pmid:3930208
Sakai T et al. Very long-chain fatty acids in neutral lipids and glycerophospholipids of adrenoleukodystrophy-cultured skin fibroblasts. 1985 J. Neurol. Sci. pmid:4087027
Lambert MA et al. Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. 1986 J. Clin. Microbiol. pmid:3084554
Rizzo WB et al. Adrenoleukodystrophy: oleic acid lowers fibroblast saturated C22-26 fatty acids. 1986 Neurology pmid:3951702
Tanaka K et al. Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. 1987 Neurology pmid:3587618
Watkins PA et al. Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. 1987 J. Inherit. Metab. Dis. pmid:3119941
Rizzo WB et al. Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. 1987 Ann. Neurol. pmid:3037987
Sereni C et al. Adult adrenoleukodystrophy: a sporadic case? 1987 J. Neurol. Sci. pmid:3681326
Moser HW Adrenoleukodystrophy: from bedside to molecular biology. 1987 J. Child Neurol. pmid:3598142
Singh H et al. Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. 1987 Arch. Biochem. Biophys. pmid:2437859