HEXACOSANOIC ACID

HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with HEXACOSANOIC ACID?

HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID

MeSH term MeSH ID Detail
Blepharospasm D001764 1 associated lipids
Iron Metabolism Disorders D019189 1 associated lipids
Tics D020323 1 associated lipids
Crush Syndrome D003444 1 associated lipids
Adrenocortical Hyperfunction D000308 3 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Metabolic Diseases D008659 12 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 | Total 17

PubChem Associated disorders and diseases

What pathways are associated with HEXACOSANOIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with HEXACOSANOIC ACID?

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Location Cross reference Weighted score Related literatures
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What functions are associated with HEXACOSANOIC ACID?


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Function Cross reference Weighted score Related literatures

What lipids are associated with HEXACOSANOIC ACID?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with HEXACOSANOIC ACID?

Knock-out

Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with HEXACOSANOIC ACID

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Authors Title Published Journal PubMed Link
Jakobs BS and Wanders RJ Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. 1991 Biochem. Biophys. Res. Commun. pmid:1872864
Kawamura N et al. High concentration of hexacosanoate in cultured skin fibroblast lipids from adrenoleukodystrophy patients. 1978 Biochem. Biophys. Res. Commun. pmid:666828
Kishimoto Y et al. Adrenoleukodystrophy: evidence that abnormal very long chain fatty acids of brain cholesterol esters are of exogenous origin. 1980 Biochem. Biophys. Res. Commun. pmid:7437052
Vargas CR et al. Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. 2004 Biochim. Biophys. Acta pmid:14732478
Lageweg W et al. Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. 1991 Biochim. Biophys. Acta pmid:1911873
Boggs JM et al. Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. 1988 Biochim. Biophys. Acta pmid:3349071
Bojesen IN Direct determination of unbound lipophilic ligands in aqueous solutions. 2004 Biol Proced Online pmid:19565308
Veerapen N et al. Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. 2011 Bioorg. Med. Chem. pmid:21145749
Veerapen N et al. Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. 2010 Bioorg. Med. Chem. Lett. pmid:20462758
Veerapen N et al. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. 2009 Bioorg. Med. Chem. Lett. pmid:19502056