| MeSH term | MeSH ID | Detail |
|---|---|---|
| Crush Syndrome | D003444 | 1 associated lipids |
| Blepharospasm | D001764 | 1 associated lipids |
| Iron Metabolism Disorders | D019189 | 1 associated lipids |
| Tics | D020323 | 1 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wanders RJ et al. | Direct demonstration that the deficient oxidation of very long chain fatty acids in X-linked adrenoleukodystrophy is due to an impaired ability of peroxisomes to activate very long chain fatty acids. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3382393 |
| Kawamura N et al. | High concentration of hexacosanoate in cultured skin fibroblast lipids from adrenoleukodystrophy patients. | 1978 | Biochem. Biophys. Res. Commun. | pmid:666828 |
| Kishimoto Y et al. | Adrenoleukodystrophy: evidence that abnormal very long chain fatty acids of brain cholesterol esters are of exogenous origin. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437052 |
| Vargas CR et al. | Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. | 2004 | Biochim. Biophys. Acta | pmid:14732478 |
| Lageweg W et al. | Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. | 1991 | Biochim. Biophys. Acta | pmid:1911873 |
| Boggs JM et al. | Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. | 1988 | Biochim. Biophys. Acta | pmid:3349071 |
| Bojesen IN | Direct determination of unbound lipophilic ligands in aqueous solutions. | 2004 | Biol Proced Online | pmid:19565308 |
| Veerapen N et al. | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. | 2011 | Bioorg. Med. Chem. | pmid:21145749 |
| Veerapen N et al. | Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462758 |
| Veerapen N et al. | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19502056 |