HEXACOSANOIC ACID

HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with HEXACOSANOIC ACID?

HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Metabolic Diseases D008659 12 associated lipids
Adrenocortical Hyperfunction D000308 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with HEXACOSANOIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with HEXACOSANOIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with HEXACOSANOIC ACID?

Knock-out

Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with HEXACOSANOIC ACID

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Per page 10 20 50 100 | Total 136
Authors Title Published Journal PubMed Link
pmid:
Pai GS et al. Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. 2000 Mol. Genet. Metab. pmid:10870849
Petroni A et al. Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. 2000 Neurosci. Lett. pmid:10904139
Antoku Y et al. Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. 2000 Atherosclerosis pmid:11058712
Tomosaka H et al. Lupeol esters from the twig bark of Japanese pear (Pyrus serotina Rehd.) cv. Shinko. 2001 Biosci. Biotechnol. Biochem. pmid:11440139
Rudenskaia GE et al. [Clinical heterogeneity of X-linked adrenoleukodystrophy ]. 2002 Zh Nevrol Psikhiatr Im S S Korsakova pmid:12497991
Wen J et al. [Studies on the chemical constituent of Ephedra likiangensis]. 1997 Zhong Yao Cai pmid:12572520
Tao ZY et al. [Studies on the chemical constituents of Zanthoxylum dimorphophyllum Hemsl. var spinifolium Rhed. et Wils]. 2001 Yao Xue Xue Bao pmid:12585082
Lii JR et al. [Lipid compounds from Echinacea purpurea]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12774354
Chen JH et al. [Clinical evaluation of 546 tetracycline-stained teeth treated with Cerinate laminate veneers]. 2003 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:12887798