| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Molzer B et al. | Fatty acid patterns in brain, fibroblast, leukocyte and body fluid lipids in adrenoleukodystrophy. | 1981 | Acta Neuropathol Suppl | pmid:6939237 |
| Ginanni Corradini S et al. | Plasma fatty acid lipidome is associated with cirrhosis prognosis and graft damage in liver transplantation. | 2014 | Am. J. Clin. Nutr. | pmid:24965302 |
| Van Duyn MA et al. | The design of a diet restricted in saturated very long-chain fatty acids: therapeutic application in adrenoleukodystrophy. | 1984 | Am. J. Clin. Nutr. | pmid:6465061 |
| Fourcade S et al. | A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854420 |
| Nagy K et al. | An HPLC-MS approach for analysis of very long chain fatty acids and other apolar compounds on octadecyl-silica phase using partly miscible solvents. | 2004 | Anal. Chem. | pmid:15053654 |
| Hsu WY et al. | Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. | 2010 | Anal. Chem. | pmid:20704371 |
| Chung TC et al. | A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives. | 2008 | Anal. Chim. Acta | pmid:18298975 |
| López-Erauskin J et al. | Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. | 2011 | Ann. Neurol. | pmid:21786300 |
| Rizzo WB et al. | Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. | 1987 | Ann. Neurol. | pmid:3037987 |
| Moser AB et al. | A new dietary therapy for adrenoleukodystrophy: biochemical and preliminary clinical results in 36 patients. | 1987 | Ann. Neurol. | pmid:2440378 |
| Moser HW et al. | Adrenoleukodystrophy: elevated C26 fatty acid in cultured skin fibroblasts. | 1980 | Ann. Neurol. | pmid:7436359 |
| Moser HW et al. | Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. | 1984 | Ann. Neurol. | pmid:6524872 |
| Singh H et al. | Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. | 1987 | Arch. Biochem. Biophys. | pmid:2437859 |
| Moser HW et al. | Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's oil. | 2005 | Arch. Neurol. | pmid:16009761 |
| Chen YG et al. | 11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi. | 2005 | Arch. Pharm. Res. | pmid:16276973 |
| Miyazaki T et al. | High hexacosanoic acid levels are associated with coronary artery disease. | 2014 | Atherosclerosis | pmid:24530774 |
| Antoku Y et al. | Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. | 2000 | Atherosclerosis | pmid:11058712 |
| Dang NA et al. | Rapid diagnosis of TB using GC-MS and chemometrics. | 2013 | Bioanalysis | pmid:24320132 |
| Jakobs BS and Wanders RJ | Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872864 |
| Wanders RJ et al. | Direct demonstration that the deficient oxidation of very long chain fatty acids in X-linked adrenoleukodystrophy is due to an impaired ability of peroxisomes to activate very long chain fatty acids. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3382393 |
| Kawamura N et al. | High concentration of hexacosanoate in cultured skin fibroblast lipids from adrenoleukodystrophy patients. | 1978 | Biochem. Biophys. Res. Commun. | pmid:666828 |
| Kishimoto Y et al. | Adrenoleukodystrophy: evidence that abnormal very long chain fatty acids of brain cholesterol esters are of exogenous origin. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437052 |
| Vargas CR et al. | Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. | 2004 | Biochim. Biophys. Acta | pmid:14732478 |
| Lageweg W et al. | Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. | 1991 | Biochim. Biophys. Acta | pmid:1911873 |
| Boggs JM et al. | Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. | 1988 | Biochim. Biophys. Acta | pmid:3349071 |
| Bojesen IN | Direct determination of unbound lipophilic ligands in aqueous solutions. | 2004 | Biol Proced Online | pmid:19565308 |
| Veerapen N et al. | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. | 2011 | Bioorg. Med. Chem. | pmid:21145749 |
| Veerapen N et al. | Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462758 |
| Veerapen N et al. | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19502056 |
| Tomosaka H et al. | Lupeol esters from the twig bark of Japanese pear (Pyrus serotina Rehd.) cv. Shinko. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440139 |
| Yuan C et al. | Mychonastes afer HSO-3-1 as a potential new source of biodiesel. | 2011 | Biotechnol Biofuels | pmid:22040677 |
| Broz AK et al. | Plant neighbor identity influences plant biochemistry and physiology related to defense. | 2010 | BMC Plant Biol. | pmid:20565801 |
| Brites P et al. | Plasmalogens participate in very-long-chain fatty acid-induced pathology. | 2009 | Brain | pmid:19022859 |
| Jardim LB et al. | X-linked adrenoleukodystrophy: clinical course and minimal incidence in South Brazil. | 2010 | Brain Dev. | pmid:19269120 |
| Dhaunsi GS et al. | Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts. | 2005 Jan-Feb | Cell Biochem. Funct. | pmid:15565636 |
| Mika A et al. | Hyper-Elongation in Colorectal Cancer Tissue - Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies. | 2017 | Cell. Physiol. Biochem. | pmid:28214830 |
| Aveldaño MI and Donnari D | Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. | 1996 | Clin. Chem. | pmid:8598113 |
| Harris HM et al. | Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. | 1989 | Clin. Chem. | pmid:2702761 |
| Wanders RJ et al. | Prenatal diagnosis of Zellweger syndrome by measurement of very long chain fatty acid (C26:0) beta-oxidation in cultured chorionic villous fibroblasts: implications for early diagnosis of other peroxisomal disorders. | 1987 | Clin. Chim. Acta | pmid:3652452 |
| Bakkeren JA et al. | Serum very long chain fatty acid pattern in Zellweger syndrome. | 1984 | Clin. Chim. Acta | pmid:6723067 |
| Miwa A et al. | Very long-chain fatty acid pattern in crush syndrome patients in the Kobe earthquake. | 1997 | Clin. Chim. Acta | pmid:9074810 |
| Okahashi A et al. | Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children. | 2009 | Clin. Chim. Acta | pmid:19135040 |
| Nasrallah F et al. | X-linked Adrenoleukodystrophy, The Tunisian Experience. | 2015 | Clin. Lab. | pmid:26642716 |
| Huang CW and Hsueh CH | Piston-on-three-ball versus piston-on-ring in evaluating the biaxial strength of dental ceramics. | 2011 | Dent Mater | pmid:21459428 |
| Kume A et al. | High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. | 2008 | Diabetes Res. Clin. Pract. | pmid:18242759 |
| Krause KH et al. | [EMG and evoked potentials in adrenomyeloneuropathy]. | 1985 | EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb | pmid:3930208 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| El Hajj HI et al. | The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy). | 2012 | Endocrinology | pmid:22508517 |
| Ryabova NY et al. | Investigation of stratum corneum lipid model membranes with free fatty acid composition by neutron diffraction. | 2010 | Eur. Biophys. J. | pmid:20012954 |
| Lageweg W et al. | Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. | 1991 | Eur. J. Biochem. | pmid:2007410 |
| Joffry SM et al. | Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. | 2012 | Evid Based Complement Alternat Med | pmid:22242040 |
| Matias AC et al. | Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. | 2007 | Free Radic. Biol. Med. | pmid:17936191 |
| Gutierrez AL et al. | Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. | 2007 | Glycobiology | pmid:17369287 |
| Chen JH et al. | [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. | 2006 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:17334072 |
| Boué J et al. | First trimester prenatal diagnosis of adrenoleukodystrophy by determination of very long chain fatty acid levels and by linkage analysis to a DNA probe. | 1985 | Hum. Genet. | pmid:3856557 |
| Fourcade S et al. | Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy. | 2010 | Hum. Mol. Genet. | pmid:20179078 |
| Fourcade S et al. | Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. | 2008 | Hum. Mol. Genet. | pmid:18344354 |
| Schlüter A et al. | Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. | 2012 | Hum. Mol. Genet. | pmid:22095690 |
| Deon M et al. | Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. | 2007 | Int. J. Dev. Neurosci. | pmid:17928186 |
| Deng F et al. | New flavonoids and other constituents from Lespedeza cuneata. | J Asian Nat Prod Res | pmid:17943561 | |
| Kaal E et al. | A fast method for the identification of Mycobacterium tuberculosis in sputum and cultures based on thermally assisted hydrolysis and methylation followed by gas chromatography-mass spectrometry. | 2009 | J Chromatogr A | pmid:19631943 |
| Chen JH et al. | Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers. | 2005 | J Dent | pmid:15652162 |
| Bai Y et al. | Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. | 2011 | J Nat Med | pmid:21301979 |
| Meng Z et al. | Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. | 2007 | J Sep Sci | pmid:17623434 |
| Zarrouk A et al. | Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. | 2015 | J. Alzheimers Dis. | pmid:25428249 |
| Tsuji S et al. | Increased synthesis of hexacosanoic acid (C23:0) by cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1981 | J. Biochem. | pmid:7309718 |
| Pillai BK et al. | Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. | 2009 | J. Biol. Chem. | pmid:19801636 |
| Shivashankar S and Sumathi M | Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? | 2015 | J. Biosci. | pmid:25963264 |
| Moser HW | Adrenoleukodystrophy: from bedside to molecular biology. | 1987 | J. Child Neurol. | pmid:3598142 |
| Caruso U et al. | Determination of very-long-chain fatty acids in plasma by a simplified gas chromatographic-mass spectrometric procedure. | 1991 | J. Chromatogr. | pmid:2026688 |
| Wanders RJ et al. | Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. | 1987 | J. Clin. Invest. | pmid:3680527 |
| Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
| Lambert MA et al. | Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. | 1986 | J. Clin. Microbiol. | pmid:3084554 |
| Cappa M et al. | Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? | 2011 | J. Endocrinol. Invest. | pmid:21399389 |
| Engelen M et al. | Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation. | 2012 | J. Inherit. Metab. Dis. | pmid:22447153 |
| Cappa M et al. | A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers. | 2012 | J. Inherit. Metab. Dis. | pmid:22189598 |
| Watkins PA et al. | Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. | 1987 | J. Inherit. Metab. Dis. | pmid:3119941 |
| Govaerts L et al. | Disturbed very long chain (C24-C26) fatty acid pattern in fibroblasts of patients with Zellweger's syndrome. | 1985 | J. Inherit. Metab. Dis. | pmid:3921760 |
| Christensen E et al. | A new peroxisomal beta-oxidation disorder in twin neonates: defective oxidation of both cerotic and pristanic acids. | 1997 | J. Inherit. Metab. Dis. | pmid:9323560 |
| Ohta M et al. | Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). | 2007 | J. Lipid Res. | pmid:17164223 |
| Gunasekera SP et al. | Constituents of Nealchornea yapurenis (Euophorbiaceae). | 1980 Mar-Apr | J. Nat. Prod. | pmid:7381509 |
| Tsuji S et al. | Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1985 | J. Neurol. Sci. | pmid:4087029 |
| Deon M et al. | The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. | 2006 | J. Neurol. Sci. | pmid:16750542 |
| Wanders RJ et al. | Infantile phytanic acid storage disease, a disorder of peroxisome biogenesis: a case report. | 1990 | J. Neurol. Sci. | pmid:1700075 |
| Sereni C et al. | Adult adrenoleukodystrophy: a sporadic case? | 1987 | J. Neurol. Sci. | pmid:3681326 |
| Sakai T et al. | Very long-chain fatty acids in neutral lipids and glycerophospholipids of adrenoleukodystrophy-cultured skin fibroblasts. | 1985 | J. Neurol. Sci. | pmid:4087027 |
| Yamamoto Y et al. | Chemical Synthesis of a Very Long-Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid. | 2015 | J. Nutr. Sci. Vitaminol. | pmid:26226958 |
| Kawahara K et al. | Hexacosanoate contents in Japanese common foods. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:3244051 |
| Wanders RJ et al. | Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. | 1988 | Lancet | pmid:2899227 |
| Yanagisawa N et al. | Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 | Lipids Health Dis | pmid:19038055 |
| Deon M et al. | Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect. | 2008 | Metab Brain Dis | pmid:18026827 |
| Rockenbach FJ et al. | The effect of bone marrow transplantation on oxidative stress in X-linked adrenoleukodystrophy. | 2012 | Mol. Genet. Metab. | pmid:22525090 |
| Hubbard WC et al. | Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings. | 2006 Sep-Oct | Mol. Genet. Metab. | pmid:16828324 |
| Pai GS et al. | Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. | 2000 | Mol. Genet. Metab. | pmid:10870849 |
| Wilkins A et al. | Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. | 2009 | Mult. Scler. | pmid:19965514 |
| Engelen M et al. | Lovastatin in X-linked adrenoleukodystrophy. | 2010 | N. Engl. J. Med. | pmid:20089986 |
| Sadeghi-Nejad A and Senior B | Adrenomyeloneuropathy presenting as Addison's disease in childhood. | 1990 | N. Engl. J. Med. | pmid:2294415 |
| Moser AE et al. | The cerebrohepatorenal (Zellweger) syndrome. Increased levels and impaired degradation of very-long-chain fatty acids and their use in prenatal diagnosis. | 1984 | N. Engl. J. Med. | pmid:6709009 |
| Khan MA et al. | Phytochemical investigation of the fruit peels of Citrus reticulata Blanco. | 2010 | Nat. Prod. Res. | pmid:20401792 |