| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Pai GS et al. | Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. | 2000 | Mol. Genet. Metab. | pmid:10870849 |
| Petroni A et al. | Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. | 2000 | Neurosci. Lett. | pmid:10904139 |
| Antoku Y et al. | Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. | 2000 | Atherosclerosis | pmid:11058712 |
| Tomosaka H et al. | Lupeol esters from the twig bark of Japanese pear (Pyrus serotina Rehd.) cv. Shinko. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440139 |
| Rudenskaia GE et al. | [Clinical heterogeneity of X-linked adrenoleukodystrophy ]. | 2002 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:12497991 |
| Wen J et al. | [Studies on the chemical constituent of Ephedra likiangensis]. | 1997 | Zhong Yao Cai | pmid:12572520 |
| Tao ZY et al. | [Studies on the chemical constituents of Zanthoxylum dimorphophyllum Hemsl. var spinifolium Rhed. et Wils]. | 2001 | Yao Xue Xue Bao | pmid:12585082 |
| Lii JR et al. | [Lipid compounds from Echinacea purpurea]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774354 |
| Chen JH et al. | [Clinical evaluation of 546 tetracycline-stained teeth treated with Cerinate laminate veneers]. | 2003 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:12887798 |
| Singh B and Singh S | Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. | 2003 | Phytother Res | pmid:12916085 |
| Di Biase A et al. | Free radical release in C6 glial cells enriched in hexacosanoic acid: implication for X-linked adrenoleukodystrophy pathogenesis. | 2004 | Neurochem. Int. | pmid:14602084 |
| Vargas CR et al. | Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. | 2004 | Biochim. Biophys. Acta | pmid:14732478 |
| Nagy K et al. | An HPLC-MS approach for analysis of very long chain fatty acids and other apolar compounds on octadecyl-silica phase using partly miscible solvents. | 2004 | Anal. Chem. | pmid:15053654 |
| Zhang C and Fang YX | [Studies on the chemical constituents of Chinese herb Melastoma dodecandrum]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15139128 |
| Dhaunsi GS et al. | Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts. | 2005 Jan-Feb | Cell Biochem. Funct. | pmid:15565636 |
| Cheng J et al. | [Studies on the constituents from the stems of Spatholobus suberectus]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617498 |
| Chen JH et al. | Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers. | 2005 | J Dent | pmid:15652162 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| Ramjit HG et al. | A novel coaxial electrospray ionization method for characterizing hexacosanoylceramides by Fourier transform ion cyclotron resonance mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15838927 |
| Moser HW et al. | Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's oil. | 2005 | Arch. Neurol. | pmid:16009761 |
| Chen YG et al. | 11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi. | 2005 | Arch. Pharm. Res. | pmid:16276973 |
| Deon M et al. | The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. | 2006 | J. Neurol. Sci. | pmid:16750542 |
| Hubbard WC et al. | Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings. | 2006 Sep-Oct | Mol. Genet. Metab. | pmid:16828324 |
| Wanders RJ et al. | Infantile phytanic acid storage disease, a disorder of peroxisome biogenesis: a case report. | 1990 | J. Neurol. Sci. | pmid:1700075 |
| Chen YG et al. | Compounds with DNA cleaving activity from Kadsura ananosma. | 2006 | Pharmazie | pmid:17069433 |
| Ohta M et al. | Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). | 2007 | J. Lipid Res. | pmid:17164223 |
| Chen JH et al. | [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. | 2006 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:17334072 |
| Gutierrez AL et al. | Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. | 2007 | Glycobiology | pmid:17369287 |
| Meng Z et al. | Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. | 2007 | J Sep Sci | pmid:17623434 |
| Deon M et al. | Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. | 2007 | Int. J. Dev. Neurosci. | pmid:17928186 |
| Matias AC et al. | Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. | 2007 | Free Radic. Biol. Med. | pmid:17936191 |
| Deng F et al. | New flavonoids and other constituents from Lespedeza cuneata. | J Asian Nat Prod Res | pmid:17943561 | |
| Deon M et al. | Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect. | 2008 | Metab Brain Dis | pmid:18026827 |
| Qin WJ et al. | [Studies on chemical constituents of Heterosmilax yunnanensis]. | 2007 | Zhong Yao Cai | pmid:18074845 |
| Di Benedetto R et al. | RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function. | 2008 | Neurochem. Int. | pmid:18178290 |
| Kume A et al. | High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. | 2008 | Diabetes Res. Clin. Pract. | pmid:18242759 |
| Chung TC et al. | A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives. | 2008 | Anal. Chim. Acta | pmid:18298975 |
| Fourcade S et al. | Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. | 2008 | Hum. Mol. Genet. | pmid:18344354 |
| Jakobs BS and Wanders RJ | Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872864 |
| Fourcade S et al. | A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854420 |
| Brites P et al. | Plasmalogens participate in very-long-chain fatty acid-induced pathology. | 2009 | Brain | pmid:19022859 |
| Yanagisawa N et al. | Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 | Lipids Health Dis | pmid:19038055 |
| Lageweg W et al. | Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. | 1991 | Biochim. Biophys. Acta | pmid:1911873 |
| Okahashi A et al. | Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children. | 2009 | Clin. Chim. Acta | pmid:19135040 |
| Figueiras AN et al. | Epicuticular lipids induce aggregation in Chagas disease vectors. | 2009 | Parasit Vectors | pmid:19173716 |
| Jardim LB et al. | X-linked adrenoleukodystrophy: clinical course and minimal incidence in South Brazil. | 2010 | Brain Dev. | pmid:19269120 |
| Rezanka T and Sigler K | Odd-numbered very-long-chain fatty acids from the microbial, animal and plant kingdoms. | 2009 May-Jul | Prog. Lipid Res. | pmid:19336244 |
| Veerapen N et al. | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19502056 |
| Bojesen IN | Direct determination of unbound lipophilic ligands in aqueous solutions. | 2004 | Biol Proced Online | pmid:19565308 |
| Kaal E et al. | A fast method for the identification of Mycobacterium tuberculosis in sputum and cultures based on thermally assisted hydrolysis and methylation followed by gas chromatography-mass spectrometry. | 2009 | J Chromatogr A | pmid:19631943 |
| Pillai BK et al. | Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. | 2009 | J. Biol. Chem. | pmid:19801636 |
| Wilkins A et al. | Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. | 2009 | Mult. Scler. | pmid:19965514 |
| Ryabova NY et al. | Investigation of stratum corneum lipid model membranes with free fatty acid composition by neutron diffraction. | 2010 | Eur. Biophys. J. | pmid:20012954 |
| Khare G et al. | Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. | 2009 | PLoS ONE | pmid:20027301 |
| Lageweg W et al. | Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. | 1991 | Eur. J. Biochem. | pmid:2007410 |
| Engelen M et al. | Lovastatin in X-linked adrenoleukodystrophy. | 2010 | N. Engl. J. Med. | pmid:20089986 |
| Fourcade S et al. | Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy. | 2010 | Hum. Mol. Genet. | pmid:20179078 |
| Caruso U et al. | Determination of very-long-chain fatty acids in plasma by a simplified gas chromatographic-mass spectrometric procedure. | 1991 | J. Chromatogr. | pmid:2026688 |
| Xue Q et al. | Two new compounds from Semen celosiae and their protective effects against CClâ‚„-induced hepatotoxicity. | 2011 | Nat. Prod. Res. | pmid:20306359 |
| Khan MA et al. | Phytochemical investigation of the fruit peels of Citrus reticulata Blanco. | 2010 | Nat. Prod. Res. | pmid:20401792 |
| Veerapen N et al. | Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20462758 |
| Broz AK et al. | Plant neighbor identity influences plant biochemistry and physiology related to defense. | 2010 | BMC Plant Biol. | pmid:20565801 |
| Hsu WY et al. | Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. | 2010 | Anal. Chem. | pmid:20704371 |
| Veerapen N et al. | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. | 2011 | Bioorg. Med. Chem. | pmid:21145749 |
| Bai Y et al. | Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. | 2011 | J Nat Med | pmid:21301979 |
| Cappa M et al. | Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? | 2011 | J. Endocrinol. Invest. | pmid:21399389 |
| Huang CW and Hsueh CH | Piston-on-three-ball versus piston-on-ring in evaluating the biaxial strength of dental ceramics. | 2011 | Dent Mater | pmid:21459428 |
| López-Erauskin J et al. | Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. | 2011 | Ann. Neurol. | pmid:21786300 |
| Yuan C et al. | Mychonastes afer HSO-3-1 as a potential new source of biodiesel. | 2011 | Biotechnol Biofuels | pmid:22040677 |
| Schlüter A et al. | Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. | 2012 | Hum. Mol. Genet. | pmid:22095690 |
| Cappa M et al. | A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers. | 2012 | J. Inherit. Metab. Dis. | pmid:22189598 |
| Joffry SM et al. | Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. | 2012 | Evid Based Complement Alternat Med | pmid:22242040 |
| Tresch S et al. | Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. | 2012 | Phytochemistry | pmid:22284369 |
| Engelen M et al. | Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation. | 2012 | J. Inherit. Metab. Dis. | pmid:22447153 |
| El Hajj HI et al. | The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy). | 2012 | Endocrinology | pmid:22508517 |
| Rockenbach FJ et al. | The effect of bone marrow transplantation on oxidative stress in X-linked adrenoleukodystrophy. | 2012 | Mol. Genet. Metab. | pmid:22525090 |
| Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
| Lü S et al. | Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status. | 2012 | Plant Physiol. | pmid:22635115 |
| Kyllerman M et al. | Central nervous system malformations and white matter changes in pseudo-neonatal adrenoleukodystrophy. | 1990 | Neuropediatrics | pmid:2290480 |
| Sadeghi-Nejad A and Senior B | Adrenomyeloneuropathy presenting as Addison's disease in childhood. | 1990 | N. Engl. J. Med. | pmid:2294415 |
| Dang NA et al. | Rapid diagnosis of TB using GC-MS and chemometrics. | 2013 | Bioanalysis | pmid:24320132 |
| Singh H et al. | Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. | 1987 | Arch. Biochem. Biophys. | pmid:2437859 |
| Moser AB et al. | A new dietary therapy for adrenoleukodystrophy: biochemical and preliminary clinical results in 36 patients. | 1987 | Ann. Neurol. | pmid:2440378 |
| Miyazaki T et al. | High hexacosanoic acid levels are associated with coronary artery disease. | 2014 | Atherosclerosis | pmid:24530774 |
| Ginanni Corradini S et al. | Plasma fatty acid lipidome is associated with cirrhosis prognosis and graft damage in liver transplantation. | 2014 | Am. J. Clin. Nutr. | pmid:24965302 |
| Zarrouk A et al. | Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. | 2015 | J. Alzheimers Dis. | pmid:25428249 |
| Zarrouk A et al. | Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. | 2015 | Rev. Neurol. (Paris) | pmid:25577946 |
| Shivashankar S and Sumathi M | Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? | 2015 | J. Biosci. | pmid:25963264 |
| Yamamoto Y et al. | Chemical Synthesis of a Very Long-Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid. | 2015 | J. Nutr. Sci. Vitaminol. | pmid:26226958 |
| Nasrallah F et al. | X-linked Adrenoleukodystrophy, The Tunisian Experience. | 2015 | Clin. Lab. | pmid:26642716 |
| Rizzo WB et al. | Dietary erucic acid therapy for X-linked adrenoleukodystrophy. | 1989 | Neurology | pmid:2682348 |
| Harris HM et al. | Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. | 1989 | Clin. Chem. | pmid:2702761 |
| Mika A et al. | Hyper-Elongation in Colorectal Cancer Tissue - Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies. | 2017 | Cell. Physiol. Biochem. | pmid:28214830 |
| Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
| Wanders RJ et al. | Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. | 1988 | Lancet | pmid:2899227 |
| Turpin JC et al. | [Adult disclosure of a case of familial adrenoleukodystrophy]. | 1985 | Rev. Neurol. (Paris) | pmid:2990005 |
| Rizzo WB et al. | Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. | 1987 | Ann. Neurol. | pmid:3037987 |
| Lambert MA et al. | Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. | 1986 | J. Clin. Microbiol. | pmid:3084554 |
| Watkins PA et al. | Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. | 1987 | J. Inherit. Metab. Dis. | pmid:3119941 |