| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Deng F et al. | New flavonoids and other constituents from Lespedeza cuneata. | J Asian Nat Prod Res | pmid:17943561 | |
| pmid: | ||||
| Kawamura N et al. | High concentration of hexacosanoate in cultured skin fibroblast lipids from adrenoleukodystrophy patients. | 1978 | Biochem. Biophys. Res. Commun. | pmid:666828 |
| Moser HW et al. | Adrenoleukodystrophy: elevated C26 fatty acid in cultured skin fibroblasts. | 1980 | Ann. Neurol. | pmid:7436359 |
| Kishimoto Y et al. | Adrenoleukodystrophy: evidence that abnormal very long chain fatty acids of brain cholesterol esters are of exogenous origin. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437052 |
| Gunasekera SP et al. | Constituents of Nealchornea yapurenis (Euophorbiaceae). | 1980 Mar-Apr | J. Nat. Prod. | pmid:7381509 |
| Moser HW et al. | Adrenoleukodystrophy: increased plasma content of saturated very long chain fatty acids. | 1981 | Neurology | pmid:7202134 |
| Tsuji S et al. | Increased synthesis of hexacosanoic acid (C23:0) by cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1981 | J. Biochem. | pmid:7309718 |
| Molzer B et al. | Fatty acid patterns in brain, fibroblast, leukocyte and body fluid lipids in adrenoleukodystrophy. | 1981 | Acta Neuropathol Suppl | pmid:6939237 |
| Moser HW et al. | The prenatal diagnosis of adrenoleukodystrophy. Demonstration of increased hexacosanoic acid levels in cultured amniocytes and fetal adrenal gland. | 1982 | Pediatr. Res. | pmid:7063272 |
| Bakkeren JA et al. | Serum very long chain fatty acid pattern in Zellweger syndrome. | 1984 | Clin. Chim. Acta | pmid:6723067 |
| Pretorius PJ et al. | Biochemical evidence for clinically diagnosed adrenoleucodystrophy in two brothers. | 1984 | S. Afr. Med. J. | pmid:6729621 |
| Moser AE et al. | The cerebrohepatorenal (Zellweger) syndrome. Increased levels and impaired degradation of very-long-chain fatty acids and their use in prenatal diagnosis. | 1984 | N. Engl. J. Med. | pmid:6709009 |
| Van Duyn MA et al. | The design of a diet restricted in saturated very long-chain fatty acids: therapeutic application in adrenoleukodystrophy. | 1984 | Am. J. Clin. Nutr. | pmid:6465061 |
| Moser HW et al. | Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. | 1984 | Ann. Neurol. | pmid:6524872 |
| Poulos A and Sharp P | Plasma and skin fibroblast C26 fatty acids in infantile Refsum's disease. | 1984 | Neurology | pmid:6209596 |
| Tsuji S et al. | Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1985 | J. Neurol. Sci. | pmid:4087029 |
| Turpin JC et al. | [Adult disclosure of a case of familial adrenoleukodystrophy]. | 1985 | Rev. Neurol. (Paris) | pmid:2990005 |
| Boué J et al. | First trimester prenatal diagnosis of adrenoleukodystrophy by determination of very long chain fatty acid levels and by linkage analysis to a DNA probe. | 1985 | Hum. Genet. | pmid:3856557 |
| Govaerts L et al. | Disturbed very long chain (C24-C26) fatty acid pattern in fibroblasts of patients with Zellweger's syndrome. | 1985 | J. Inherit. Metab. Dis. | pmid:3921760 |
| Krause KH et al. | [EMG and evoked potentials in adrenomyeloneuropathy]. | 1985 | EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb | pmid:3930208 |
| Sakai T et al. | Very long-chain fatty acids in neutral lipids and glycerophospholipids of adrenoleukodystrophy-cultured skin fibroblasts. | 1985 | J. Neurol. Sci. | pmid:4087027 |
| Lambert MA et al. | Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. | 1986 | J. Clin. Microbiol. | pmid:3084554 |
| Rizzo WB et al. | Adrenoleukodystrophy: oleic acid lowers fibroblast saturated C22-26 fatty acids. | 1986 | Neurology | pmid:3951702 |
| Wanders RJ et al. | Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. | 1987 | J. Clin. Invest. | pmid:3680527 |
| Tanaka K et al. | Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. | 1987 | Neurology | pmid:3587618 |
| Watkins PA et al. | Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. | 1987 | J. Inherit. Metab. Dis. | pmid:3119941 |
| Rizzo WB et al. | Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. | 1987 | Ann. Neurol. | pmid:3037987 |
| Sereni C et al. | Adult adrenoleukodystrophy: a sporadic case? | 1987 | J. Neurol. Sci. | pmid:3681326 |
| Moser HW | Adrenoleukodystrophy: from bedside to molecular biology. | 1987 | J. Child Neurol. | pmid:3598142 |
| Wanders RJ et al. | Prenatal diagnosis of Zellweger syndrome by measurement of very long chain fatty acid (C26:0) beta-oxidation in cultured chorionic villous fibroblasts: implications for early diagnosis of other peroxisomal disorders. | 1987 | Clin. Chim. Acta | pmid:3652452 |
| Moser AB et al. | A new dietary therapy for adrenoleukodystrophy: biochemical and preliminary clinical results in 36 patients. | 1987 | Ann. Neurol. | pmid:2440378 |
| Singh H et al. | Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. | 1987 | Arch. Biochem. Biophys. | pmid:2437859 |
| Wanders RJ et al. | Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. | 1988 | Lancet | pmid:2899227 |
| Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
| Wanders RJ et al. | Direct demonstration that the deficient oxidation of very long chain fatty acids in X-linked adrenoleukodystrophy is due to an impaired ability of peroxisomes to activate very long chain fatty acids. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3382393 |
| Boggs JM et al. | Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. | 1988 | Biochim. Biophys. Acta | pmid:3349071 |
| Sano M et al. | [Two adult cases of adrenoleukodystrophy with clinical features of striatonigral degeneration--a probable variant of adrenoleukodystrophy]. | 1988 | Rinsho Shinkeigaku | pmid:3246111 |
| Kawahara K et al. | Hexacosanoate contents in Japanese common foods. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:3244051 |
| Harris HM et al. | Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. | 1989 | Clin. Chem. | pmid:2702761 |
| Rizzo WB et al. | Dietary erucic acid therapy for X-linked adrenoleukodystrophy. | 1989 | Neurology | pmid:2682348 |
| Wanders RJ et al. | Infantile phytanic acid storage disease, a disorder of peroxisome biogenesis: a case report. | 1990 | J. Neurol. Sci. | pmid:1700075 |
| Kyllerman M et al. | Central nervous system malformations and white matter changes in pseudo-neonatal adrenoleukodystrophy. | 1990 | Neuropediatrics | pmid:2290480 |
| Sadeghi-Nejad A and Senior B | Adrenomyeloneuropathy presenting as Addison's disease in childhood. | 1990 | N. Engl. J. Med. | pmid:2294415 |
| Jakobs BS and Wanders RJ | Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1872864 |
| Lageweg W et al. | Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. | 1991 | Biochim. Biophys. Acta | pmid:1911873 |
| Caruso U et al. | Determination of very-long-chain fatty acids in plasma by a simplified gas chromatographic-mass spectrometric procedure. | 1991 | J. Chromatogr. | pmid:2026688 |
| Lageweg W et al. | Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. | 1991 | Eur. J. Biochem. | pmid:2007410 |
| Van den Branden C et al. | Altered adrenocortical response under the influence of experimentally increased serum very long chain fatty acids in rats. | 1993 | Pathol. Res. Pract. | pmid:8397390 |
| Aveldaño MI and Donnari D | Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. | 1996 | Clin. Chem. | pmid:8598113 |
| Christensen E et al. | A new peroxisomal beta-oxidation disorder in twin neonates: defective oxidation of both cerotic and pristanic acids. | 1997 | J. Inherit. Metab. Dis. | pmid:9323560 |
| Di Biase A et al. | Effects of exogenous hexacosanoic acid on biochemical myelin composition in weaning and post-weaning rats. | 1997 | Neurochem. Res. | pmid:9051669 |
| Wen J et al. | [Studies on the chemical constituent of Ephedra likiangensis]. | 1997 | Zhong Yao Cai | pmid:12572520 |
| Miwa A et al. | Very long-chain fatty acid pattern in crush syndrome patients in the Kobe earthquake. | 1997 | Clin. Chim. Acta | pmid:9074810 |
| Miyajima H et al. | Increased very long-chain fatty acids in erythrocyte membranes of patients with aceruloplasminemia. | 1998 | Neurology | pmid:9443469 |
| Mdluli K et al. | Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. | 1998 | Science | pmid:9616124 |
| Petroni A et al. | Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. | 2000 | Neurosci. Lett. | pmid:10904139 |
| Antoku Y et al. | Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. | 2000 | Atherosclerosis | pmid:11058712 |
| Pai GS et al. | Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. | 2000 | Mol. Genet. Metab. | pmid:10870849 |
| Tomosaka H et al. | Lupeol esters from the twig bark of Japanese pear (Pyrus serotina Rehd.) cv. Shinko. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440139 |
| Tao ZY et al. | [Studies on the chemical constituents of Zanthoxylum dimorphophyllum Hemsl. var spinifolium Rhed. et Wils]. | 2001 | Yao Xue Xue Bao | pmid:12585082 |
| Lii JR et al. | [Lipid compounds from Echinacea purpurea]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774354 |
| Rudenskaia GE et al. | [Clinical heterogeneity of X-linked adrenoleukodystrophy ]. | 2002 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:12497991 |
| Singh B and Singh S | Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. | 2003 | Phytother Res | pmid:12916085 |
| Chen JH et al. | [Clinical evaluation of 546 tetracycline-stained teeth treated with Cerinate laminate veneers]. | 2003 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:12887798 |
| Cheng J et al. | [Studies on the constituents from the stems of Spatholobus suberectus]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617498 |
| Zhang C and Fang YX | [Studies on the chemical constituents of Chinese herb Melastoma dodecandrum]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15139128 |
| Vargas CR et al. | Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. | 2004 | Biochim. Biophys. Acta | pmid:14732478 |
| Bojesen IN | Direct determination of unbound lipophilic ligands in aqueous solutions. | 2004 | Biol Proced Online | pmid:19565308 |
| Nagy K et al. | An HPLC-MS approach for analysis of very long chain fatty acids and other apolar compounds on octadecyl-silica phase using partly miscible solvents. | 2004 | Anal. Chem. | pmid:15053654 |
| Di Biase A et al. | Free radical release in C6 glial cells enriched in hexacosanoic acid: implication for X-linked adrenoleukodystrophy pathogenesis. | 2004 | Neurochem. Int. | pmid:14602084 |
| Chen YG et al. | 11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi. | 2005 | Arch. Pharm. Res. | pmid:16276973 |
| Ramjit HG et al. | A novel coaxial electrospray ionization method for characterizing hexacosanoylceramides by Fourier transform ion cyclotron resonance mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15838927 |
| Chen JH et al. | Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers. | 2005 | J Dent | pmid:15652162 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| Moser HW et al. | Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's oil. | 2005 | Arch. Neurol. | pmid:16009761 |
| Dhaunsi GS et al. | Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts. | 2005 Jan-Feb | Cell Biochem. Funct. | pmid:15565636 |
| Chen JH et al. | [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. | 2006 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:17334072 |
| Deon M et al. | The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. | 2006 | J. Neurol. Sci. | pmid:16750542 |
| Chen YG et al. | Compounds with DNA cleaving activity from Kadsura ananosma. | 2006 | Pharmazie | pmid:17069433 |
| Hubbard WC et al. | Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings. | 2006 Sep-Oct | Mol. Genet. Metab. | pmid:16828324 |
| Qin WJ et al. | [Studies on chemical constituents of Heterosmilax yunnanensis]. | 2007 | Zhong Yao Cai | pmid:18074845 |
| Gutierrez AL et al. | Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. | 2007 | Glycobiology | pmid:17369287 |
| Ohta M et al. | Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). | 2007 | J. Lipid Res. | pmid:17164223 |
| Meng Z et al. | Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. | 2007 | J Sep Sci | pmid:17623434 |
| Matias AC et al. | Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. | 2007 | Free Radic. Biol. Med. | pmid:17936191 |
| Deon M et al. | Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. | 2007 | Int. J. Dev. Neurosci. | pmid:17928186 |
| Di Benedetto R et al. | RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function. | 2008 | Neurochem. Int. | pmid:18178290 |
| Kume A et al. | High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. | 2008 | Diabetes Res. Clin. Pract. | pmid:18242759 |
| Fourcade S et al. | Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. | 2008 | Hum. Mol. Genet. | pmid:18344354 |
| Yanagisawa N et al. | Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 | Lipids Health Dis | pmid:19038055 |
| Deon M et al. | Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect. | 2008 | Metab Brain Dis | pmid:18026827 |
| Chung TC et al. | A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives. | 2008 | Anal. Chim. Acta | pmid:18298975 |
| Veerapen N et al. | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19502056 |
| Fourcade S et al. | A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854420 |
| Khare G et al. | Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. | 2009 | PLoS ONE | pmid:20027301 |
| Pillai BK et al. | Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. | 2009 | J. Biol. Chem. | pmid:19801636 |
| Figueiras AN et al. | Epicuticular lipids induce aggregation in Chagas disease vectors. | 2009 | Parasit Vectors | pmid:19173716 |
| Brites P et al. | Plasmalogens participate in very-long-chain fatty acid-induced pathology. | 2009 | Brain | pmid:19022859 |
| Okahashi A et al. | Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children. | 2009 | Clin. Chim. Acta | pmid:19135040 |