HEXACOSANOIC ACID

HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with HEXACOSANOIC ACID?

HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Metabolic Diseases D008659 12 associated lipids
Adrenocortical Hyperfunction D000308 3 associated lipids
Per page 10 20 | Total 17

PubChem Associated disorders and diseases

What pathways are associated with HEXACOSANOIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with HEXACOSANOIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with HEXACOSANOIC ACID?

Knock-out

Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with HEXACOSANOIC ACID

Download all related citations
Per page 10 20 50 100 | Total 136
Authors Title Published Journal PubMed Link
Mika A et al. Hyper-Elongation in Colorectal Cancer Tissue - Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies. 2017 Cell. Physiol. Biochem. pmid:28214830
Zarrouk A et al. Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. 2015 Rev. Neurol. (Paris) pmid:25577946
Zarrouk A et al. Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. 2015 J. Alzheimers Dis. pmid:25428249
Yamamoto Y et al. Chemical Synthesis of a Very Long-Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid. 2015 J. Nutr. Sci. Vitaminol. pmid:26226958
Shivashankar S and Sumathi M Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? 2015 J. Biosci. pmid:25963264
Nasrallah F et al. X-linked Adrenoleukodystrophy, The Tunisian Experience. 2015 Clin. Lab. pmid:26642716
Miyazaki T et al. High hexacosanoic acid levels are associated with coronary artery disease. 2014 Atherosclerosis pmid:24530774
Ginanni Corradini S et al. Plasma fatty acid lipidome is associated with cirrhosis prognosis and graft damage in liver transplantation. 2014 Am. J. Clin. Nutr. pmid:24965302
Dang NA et al. Rapid diagnosis of TB using GC-MS and chemometrics. 2013 Bioanalysis pmid:24320132
Rockenbach FJ et al. The effect of bone marrow transplantation on oxidative stress in X-linked adrenoleukodystrophy. 2012 Mol. Genet. Metab. pmid:22525090
Yang P et al. Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. 2012 PLoS ONE pmid:22536429
Engelen M et al. Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation. 2012 J. Inherit. Metab. Dis. pmid:22447153
El Hajj HI et al. The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy). 2012 Endocrinology pmid:22508517
Lü S et al. Arabidopsis ECERIFERUM9 involvement in cuticle formation and maintenance of plant water status. 2012 Plant Physiol. pmid:22635115
Joffry SM et al. Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. 2012 Evid Based Complement Alternat Med pmid:22242040
Schlüter A et al. Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. 2012 Hum. Mol. Genet. pmid:22095690
Cappa M et al. A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers. 2012 J. Inherit. Metab. Dis. pmid:22189598
Tresch S et al. Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases. 2012 Phytochemistry pmid:22284369
Huang CW and Hsueh CH Piston-on-three-ball versus piston-on-ring in evaluating the biaxial strength of dental ceramics. 2011 Dent Mater pmid:21459428
Yuan C et al. Mychonastes afer HSO-3-1 as a potential new source of biodiesel. 2011 Biotechnol Biofuels pmid:22040677
López-Erauskin J et al. Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. 2011 Ann. Neurol. pmid:21786300
Veerapen N et al. Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. 2011 Bioorg. Med. Chem. pmid:21145749
Cappa M et al. Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? 2011 J. Endocrinol. Invest. pmid:21399389
Xue Q et al. Two new compounds from Semen celosiae and their protective effects against CClâ‚„-induced hepatotoxicity. 2011 Nat. Prod. Res. pmid:20306359
Bai Y et al. Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. 2011 J Nat Med pmid:21301979
Ryabova NY et al. Investigation of stratum corneum lipid model membranes with free fatty acid composition by neutron diffraction. 2010 Eur. Biophys. J. pmid:20012954
Fourcade S et al. Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy. 2010 Hum. Mol. Genet. pmid:20179078
Veerapen N et al. Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000. 2010 Bioorg. Med. Chem. Lett. pmid:20462758
Broz AK et al. Plant neighbor identity influences plant biochemistry and physiology related to defense. 2010 BMC Plant Biol. pmid:20565801
Engelen M et al. Lovastatin in X-linked adrenoleukodystrophy. 2010 N. Engl. J. Med. pmid:20089986
Hsu WY et al. Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. 2010 Anal. Chem. pmid:20704371
Jardim LB et al. X-linked adrenoleukodystrophy: clinical course and minimal incidence in South Brazil. 2010 Brain Dev. pmid:19269120
Khan MA et al. Phytochemical investigation of the fruit peels of Citrus reticulata Blanco. 2010 Nat. Prod. Res. pmid:20401792
Rezanka T and Sigler K Odd-numbered very-long-chain fatty acids from the microbial, animal and plant kingdoms. 2009 May-Jul Prog. Lipid Res. pmid:19336244
Veerapen N et al. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. 2009 Bioorg. Med. Chem. Lett. pmid:19502056
Fourcade S et al. A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:18854420
Khare G et al. Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis. 2009 PLoS ONE pmid:20027301
Pillai BK et al. Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. 2009 J. Biol. Chem. pmid:19801636
Wilkins A et al. Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. 2009 Mult. Scler. pmid:19965514
Figueiras AN et al. Epicuticular lipids induce aggregation in Chagas disease vectors. 2009 Parasit Vectors pmid:19173716
Brites P et al. Plasmalogens participate in very-long-chain fatty acid-induced pathology. 2009 Brain pmid:19022859
Okahashi A et al. Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children. 2009 Clin. Chim. Acta pmid:19135040
Kaal E et al. A fast method for the identification of Mycobacterium tuberculosis in sputum and cultures based on thermally assisted hydrolysis and methylation followed by gas chromatography-mass spectrometry. 2009 J Chromatogr A pmid:19631943
Di Benedetto R et al. RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function. 2008 Neurochem. Int. pmid:18178290
Kume A et al. High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. 2008 Diabetes Res. Clin. Pract. pmid:18242759
Fourcade S et al. Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. 2008 Hum. Mol. Genet. pmid:18344354
Yanagisawa N et al. Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. 2008 Lipids Health Dis pmid:19038055
Deon M et al. Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect. 2008 Metab Brain Dis pmid:18026827
Chung TC et al. A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives. 2008 Anal. Chim. Acta pmid:18298975
Qin WJ et al. [Studies on chemical constituents of Heterosmilax yunnanensis]. 2007 Zhong Yao Cai pmid:18074845
Gutierrez AL et al. Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. 2007 Glycobiology pmid:17369287
Ohta M et al. Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). 2007 J. Lipid Res. pmid:17164223
Meng Z et al. Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. 2007 J Sep Sci pmid:17623434
Matias AC et al. Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. 2007 Free Radic. Biol. Med. pmid:17936191
Deon M et al. Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. 2007 Int. J. Dev. Neurosci. pmid:17928186
Hubbard WC et al. Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings. 2006 Sep-Oct Mol. Genet. Metab. pmid:16828324
Chen JH et al. [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. 2006 Hua Xi Kou Qiang Yi Xue Za Zhi pmid:17334072
Deon M et al. The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. 2006 J. Neurol. Sci. pmid:16750542
Chen YG et al. Compounds with DNA cleaving activity from Kadsura ananosma. 2006 Pharmazie pmid:17069433
Dhaunsi GS et al. Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts. 2005 Jan-Feb Cell Biochem. Funct. pmid:15565636
Chen YG et al. 11-Methoxyviburtinal, a new iridoid from Valeriana jatamansi. 2005 Arch. Pharm. Res. pmid:16276973
Ramjit HG et al. A novel coaxial electrospray ionization method for characterizing hexacosanoylceramides by Fourier transform ion cyclotron resonance mass spectrometry. 2005 Rapid Commun. Mass Spectrom. pmid:15838927
Chen JH et al. Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers. 2005 J Dent pmid:15652162
Vallée B and Riezman H Lip1p: a novel subunit of acyl-CoA ceramide synthase. 2005 EMBO J. pmid:15692566
Moser HW et al. Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's oil. 2005 Arch. Neurol. pmid:16009761
Vargas CR et al. Evidence that oxidative stress is increased in patients with X-linked adrenoleukodystrophy. 2004 Biochim. Biophys. Acta pmid:14732478
Bojesen IN Direct determination of unbound lipophilic ligands in aqueous solutions. 2004 Biol Proced Online pmid:19565308
Nagy K et al. An HPLC-MS approach for analysis of very long chain fatty acids and other apolar compounds on octadecyl-silica phase using partly miscible solvents. 2004 Anal. Chem. pmid:15053654
Di Biase A et al. Free radical release in C6 glial cells enriched in hexacosanoic acid: implication for X-linked adrenoleukodystrophy pathogenesis. 2004 Neurochem. Int. pmid:14602084
Singh B and Singh S Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. 2003 Phytother Res pmid:12916085
Chen JH et al. [Clinical evaluation of 546 tetracycline-stained teeth treated with Cerinate laminate veneers]. 2003 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:12887798
Cheng J et al. [Studies on the constituents from the stems of Spatholobus suberectus]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617498
Zhang C and Fang YX [Studies on the chemical constituents of Chinese herb Melastoma dodecandrum]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15139128
Lii JR et al. [Lipid compounds from Echinacea purpurea]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12774354
Rudenskaia GE et al. [Clinical heterogeneity of X-linked adrenoleukodystrophy ]. 2002 Zh Nevrol Psikhiatr Im S S Korsakova pmid:12497991
Tomosaka H et al. Lupeol esters from the twig bark of Japanese pear (Pyrus serotina Rehd.) cv. Shinko. 2001 Biosci. Biotechnol. Biochem. pmid:11440139
Tao ZY et al. [Studies on the chemical constituents of Zanthoxylum dimorphophyllum Hemsl. var spinifolium Rhed. et Wils]. 2001 Yao Xue Xue Bao pmid:12585082
Petroni A et al. Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. 2000 Neurosci. Lett. pmid:10904139
Antoku Y et al. Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. 2000 Atherosclerosis pmid:11058712
Pai GS et al. Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. 2000 Mol. Genet. Metab. pmid:10870849
Miyajima H et al. Increased very long-chain fatty acids in erythrocyte membranes of patients with aceruloplasminemia. 1998 Neurology pmid:9443469
Mdluli K et al. Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. 1998 Science pmid:9616124
Christensen E et al. A new peroxisomal beta-oxidation disorder in twin neonates: defective oxidation of both cerotic and pristanic acids. 1997 J. Inherit. Metab. Dis. pmid:9323560
Di Biase A et al. Effects of exogenous hexacosanoic acid on biochemical myelin composition in weaning and post-weaning rats. 1997 Neurochem. Res. pmid:9051669
Wen J et al. [Studies on the chemical constituent of Ephedra likiangensis]. 1997 Zhong Yao Cai pmid:12572520
Miwa A et al. Very long-chain fatty acid pattern in crush syndrome patients in the Kobe earthquake. 1997 Clin. Chim. Acta pmid:9074810
Aveldaño MI and Donnari D Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. 1996 Clin. Chem. pmid:8598113
Van den Branden C et al. Altered adrenocortical response under the influence of experimentally increased serum very long chain fatty acids in rats. 1993 Pathol. Res. Pract. pmid:8397390
Jakobs BS and Wanders RJ Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. 1991 Biochem. Biophys. Res. Commun. pmid:1872864
Lageweg W et al. Oxidation of very-long-chain fatty acids in rat brain: cerotic acid is beta-oxidized exclusively in rat brain peroxisomes. 1991 Biochim. Biophys. Acta pmid:1911873
Caruso U et al. Determination of very-long-chain fatty acids in plasma by a simplified gas chromatographic-mass spectrometric procedure. 1991 J. Chromatogr. pmid:2026688
Lageweg W et al. Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. 1991 Eur. J. Biochem. pmid:2007410
Wanders RJ et al. Infantile phytanic acid storage disease, a disorder of peroxisome biogenesis: a case report. 1990 J. Neurol. Sci. pmid:1700075
Kyllerman M et al. Central nervous system malformations and white matter changes in pseudo-neonatal adrenoleukodystrophy. 1990 Neuropediatrics pmid:2290480
Sadeghi-Nejad A and Senior B Adrenomyeloneuropathy presenting as Addison's disease in childhood. 1990 N. Engl. J. Med. pmid:2294415
Harris HM et al. Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. 1989 Clin. Chem. pmid:2702761
Rizzo WB et al. Dietary erucic acid therapy for X-linked adrenoleukodystrophy. 1989 Neurology pmid:2682348
Whitcomb RW et al. Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. 1988 J. Clin. Invest. pmid:2891726
Wanders RJ et al. Direct demonstration that the deficient oxidation of very long chain fatty acids in X-linked adrenoleukodystrophy is due to an impaired ability of peroxisomes to activate very long chain fatty acids. 1988 Biochem. Biophys. Res. Commun. pmid:3382393
Boggs JM et al. Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. 1988 Biochim. Biophys. Acta pmid:3349071