HEXACOSANOIC ACID

HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with HEXACOSANOIC ACID?

HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Diseases D007674 29 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Arteriosclerosis D001161 86 associated lipids
Metabolic Diseases D008659 12 associated lipids
Adrenocortical Hyperfunction D000308 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with HEXACOSANOIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with HEXACOSANOIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with HEXACOSANOIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with HEXACOSANOIC ACID?

Knock-out

Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with HEXACOSANOIC ACID

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Authors Title Published Journal PubMed Link
Nasrallah F et al. X-linked Adrenoleukodystrophy, The Tunisian Experience. 2015 Clin. Lab. pmid:26642716
Rizzo WB et al. Dietary erucic acid therapy for X-linked adrenoleukodystrophy. 1989 Neurology pmid:2682348
Harris HM et al. Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. 1989 Clin. Chem. pmid:2702761
Mika A et al. Hyper-Elongation in Colorectal Cancer Tissue - Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies. 2017 Cell. Physiol. Biochem. pmid:28214830
Whitcomb RW et al. Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. 1988 J. Clin. Invest. pmid:2891726
Wanders RJ et al. Impaired ability of peroxisomes to activate very-long-chain fatty acids in X-linked adrenoleukodystrophy. 1988 Lancet pmid:2899227
Turpin JC et al. [Adult disclosure of a case of familial adrenoleukodystrophy]. 1985 Rev. Neurol. (Paris) pmid:2990005
Rizzo WB et al. Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. 1987 Ann. Neurol. pmid:3037987
Lambert MA et al. Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. 1986 J. Clin. Microbiol. pmid:3084554
Watkins PA et al. Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. 1987 J. Inherit. Metab. Dis. pmid:3119941