| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Boggs JM et al. | Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. | 1988 | Biochim. Biophys. Acta | pmid:3349071 |
| Sano M et al. | [Two adult cases of adrenoleukodystrophy with clinical features of striatonigral degeneration--a probable variant of adrenoleukodystrophy]. | 1988 | Rinsho Shinkeigaku | pmid:3246111 |
| Kawahara K et al. | Hexacosanoate contents in Japanese common foods. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:3244051 |
| Wanders RJ et al. | Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. | 1987 | J. Clin. Invest. | pmid:3680527 |
| Tanaka K et al. | Electronmicroscopic study on biopsied rectal mucosa in adrenoleukodystrophy. | 1987 | Neurology | pmid:3587618 |
| Watkins PA et al. | Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. | 1987 | J. Inherit. Metab. Dis. | pmid:3119941 |
| Rizzo WB et al. | Adrenoleukodystrophy: dietary oleic acid lowers hexacosanoate levels. | 1987 | Ann. Neurol. | pmid:3037987 |
| Sereni C et al. | Adult adrenoleukodystrophy: a sporadic case? | 1987 | J. Neurol. Sci. | pmid:3681326 |
| Moser HW | Adrenoleukodystrophy: from bedside to molecular biology. | 1987 | J. Child Neurol. | pmid:3598142 |
| Wanders RJ et al. | Prenatal diagnosis of Zellweger syndrome by measurement of very long chain fatty acid (C26:0) beta-oxidation in cultured chorionic villous fibroblasts: implications for early diagnosis of other peroxisomal disorders. | 1987 | Clin. Chim. Acta | pmid:3652452 |
| Moser AB et al. | A new dietary therapy for adrenoleukodystrophy: biochemical and preliminary clinical results in 36 patients. | 1987 | Ann. Neurol. | pmid:2440378 |
| Singh H et al. | Beta-oxidation of very-long-chain fatty acids and their coenzyme A derivatives by human skin fibroblasts. | 1987 | Arch. Biochem. Biophys. | pmid:2437859 |
| Lambert MA et al. | Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. | 1986 | J. Clin. Microbiol. | pmid:3084554 |
| Rizzo WB et al. | Adrenoleukodystrophy: oleic acid lowers fibroblast saturated C22-26 fatty acids. | 1986 | Neurology | pmid:3951702 |
| Tsuji S et al. | Metabolism of [17,18-3H2]hexacosanoic acid and [15,16-3H2]lignoceric acid in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1985 | J. Neurol. Sci. | pmid:4087029 |
| Turpin JC et al. | [Adult disclosure of a case of familial adrenoleukodystrophy]. | 1985 | Rev. Neurol. (Paris) | pmid:2990005 |
| Boué J et al. | First trimester prenatal diagnosis of adrenoleukodystrophy by determination of very long chain fatty acid levels and by linkage analysis to a DNA probe. | 1985 | Hum. Genet. | pmid:3856557 |
| Govaerts L et al. | Disturbed very long chain (C24-C26) fatty acid pattern in fibroblasts of patients with Zellweger's syndrome. | 1985 | J. Inherit. Metab. Dis. | pmid:3921760 |
| Krause KH et al. | [EMG and evoked potentials in adrenomyeloneuropathy]. | 1985 | EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb | pmid:3930208 |
| Sakai T et al. | Very long-chain fatty acids in neutral lipids and glycerophospholipids of adrenoleukodystrophy-cultured skin fibroblasts. | 1985 | J. Neurol. Sci. | pmid:4087027 |
| Bakkeren JA et al. | Serum very long chain fatty acid pattern in Zellweger syndrome. | 1984 | Clin. Chim. Acta | pmid:6723067 |
| Pretorius PJ et al. | Biochemical evidence for clinically diagnosed adrenoleucodystrophy in two brothers. | 1984 | S. Afr. Med. J. | pmid:6729621 |
| Moser AE et al. | The cerebrohepatorenal (Zellweger) syndrome. Increased levels and impaired degradation of very-long-chain fatty acids and their use in prenatal diagnosis. | 1984 | N. Engl. J. Med. | pmid:6709009 |
| Van Duyn MA et al. | The design of a diet restricted in saturated very long-chain fatty acids: therapeutic application in adrenoleukodystrophy. | 1984 | Am. J. Clin. Nutr. | pmid:6465061 |
| Moser HW et al. | Adrenoleukodystrophy: survey of 303 cases: biochemistry, diagnosis, and therapy. | 1984 | Ann. Neurol. | pmid:6524872 |
| Poulos A and Sharp P | Plasma and skin fibroblast C26 fatty acids in infantile Refsum's disease. | 1984 | Neurology | pmid:6209596 |
| Moser HW et al. | The prenatal diagnosis of adrenoleukodystrophy. Demonstration of increased hexacosanoic acid levels in cultured amniocytes and fetal adrenal gland. | 1982 | Pediatr. Res. | pmid:7063272 |
| Moser HW et al. | Adrenoleukodystrophy: increased plasma content of saturated very long chain fatty acids. | 1981 | Neurology | pmid:7202134 |
| Tsuji S et al. | Increased synthesis of hexacosanoic acid (C23:0) by cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1981 | J. Biochem. | pmid:7309718 |
| Molzer B et al. | Fatty acid patterns in brain, fibroblast, leukocyte and body fluid lipids in adrenoleukodystrophy. | 1981 | Acta Neuropathol Suppl | pmid:6939237 |
| Gunasekera SP et al. | Constituents of Nealchornea yapurenis (Euophorbiaceae). | 1980 Mar-Apr | J. Nat. Prod. | pmid:7381509 |
| Moser HW et al. | Adrenoleukodystrophy: elevated C26 fatty acid in cultured skin fibroblasts. | 1980 | Ann. Neurol. | pmid:7436359 |
| Kishimoto Y et al. | Adrenoleukodystrophy: evidence that abnormal very long chain fatty acids of brain cholesterol esters are of exogenous origin. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7437052 |
| Kawamura N et al. | High concentration of hexacosanoate in cultured skin fibroblast lipids from adrenoleukodystrophy patients. | 1978 | Biochem. Biophys. Res. Commun. | pmid:666828 |
| Deng F et al. | New flavonoids and other constituents from Lespedeza cuneata. | J Asian Nat Prod Res | pmid:17943561 | |
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