| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wanders RJ et al. | Prenatal diagnosis of Zellweger syndrome by measurement of very long chain fatty acid (C26:0) beta-oxidation in cultured chorionic villous fibroblasts: implications for early diagnosis of other peroxisomal disorders. | 1987 | Clin. Chim. Acta | pmid:3652452 |
| Bakkeren JA et al. | Serum very long chain fatty acid pattern in Zellweger syndrome. | 1984 | Clin. Chim. Acta | pmid:6723067 |
| Miwa A et al. | Very long-chain fatty acid pattern in crush syndrome patients in the Kobe earthquake. | 1997 | Clin. Chim. Acta | pmid:9074810 |
| Nasrallah F et al. | X-linked Adrenoleukodystrophy, The Tunisian Experience. | 2015 | Clin. Lab. | pmid:26642716 |
| Huang CW and Hsueh CH | Piston-on-three-ball versus piston-on-ring in evaluating the biaxial strength of dental ceramics. | 2011 | Dent Mater | pmid:21459428 |
| Kume A et al. | High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. | 2008 | Diabetes Res. Clin. Pract. | pmid:18242759 |
| Krause KH et al. | [EMG and evoked potentials in adrenomyeloneuropathy]. | 1985 | EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb | pmid:3930208 |
| Vallée B and Riezman H | Lip1p: a novel subunit of acyl-CoA ceramide synthase. | 2005 | EMBO J. | pmid:15692566 |
| El Hajj HI et al. | The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy). | 2012 | Endocrinology | pmid:22508517 |
| Ryabova NY et al. | Investigation of stratum corneum lipid model membranes with free fatty acid composition by neutron diffraction. | 2010 | Eur. Biophys. J. | pmid:20012954 |
| Lageweg W et al. | Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study. | 1991 | Eur. J. Biochem. | pmid:2007410 |
| Joffry SM et al. | Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review. | 2012 | Evid Based Complement Alternat Med | pmid:22242040 |
| Matias AC et al. | Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. | 2007 | Free Radic. Biol. Med. | pmid:17936191 |
| Gutierrez AL et al. | Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. | 2007 | Glycobiology | pmid:17369287 |
| Chen JH et al. | [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. | 2006 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:17334072 |
| Boué J et al. | First trimester prenatal diagnosis of adrenoleukodystrophy by determination of very long chain fatty acid levels and by linkage analysis to a DNA probe. | 1985 | Hum. Genet. | pmid:3856557 |
| Fourcade S et al. | Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy. | 2010 | Hum. Mol. Genet. | pmid:20179078 |
| Fourcade S et al. | Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. | 2008 | Hum. Mol. Genet. | pmid:18344354 |
| Schlüter A et al. | Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy. | 2012 | Hum. Mol. Genet. | pmid:22095690 |
| Deon M et al. | Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. | 2007 | Int. J. Dev. Neurosci. | pmid:17928186 |