| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fourcade S et al. | A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18854420 |
| Okahashi A et al. | Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children. | 2009 | Clin. Chim. Acta | pmid:19135040 |
| Kaal E et al. | A fast method for the identification of Mycobacterium tuberculosis in sputum and cultures based on thermally assisted hydrolysis and methylation followed by gas chromatography-mass spectrometry. | 2009 | J Chromatogr A | pmid:19631943 |
| Di Benedetto R et al. | RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function. | 2008 | Neurochem. Int. | pmid:18178290 |
| Kume A et al. | High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. | 2008 | Diabetes Res. Clin. Pract. | pmid:18242759 |
| Fourcade S et al. | Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. | 2008 | Hum. Mol. Genet. | pmid:18344354 |
| Yanagisawa N et al. | Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 | Lipids Health Dis | pmid:19038055 |
| Deon M et al. | Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo's oil effect. | 2008 | Metab Brain Dis | pmid:18026827 |
| Chung TC et al. | A simple and sensitive liquid chromatographic method for the analysis of free docosanoic, tetracosanoic and hexacosanoic acids in human plasma as fluorescent derivatives. | 2008 | Anal. Chim. Acta | pmid:18298975 |
| Qin WJ et al. | [Studies on chemical constituents of Heterosmilax yunnanensis]. | 2007 | Zhong Yao Cai | pmid:18074845 |
| Gutierrez AL et al. | Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. | 2007 | Glycobiology | pmid:17369287 |
| Ohta M et al. | Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). | 2007 | J. Lipid Res. | pmid:17164223 |
| Meng Z et al. | Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. | 2007 | J Sep Sci | pmid:17623434 |
| Matias AC et al. | Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. | 2007 | Free Radic. Biol. Med. | pmid:17936191 |
| Deon M et al. | Induction of lipid peroxidation and decrease of antioxidant defenses in symptomatic and asymptomatic patients with X-linked adrenoleukodystrophy. | 2007 | Int. J. Dev. Neurosci. | pmid:17928186 |
| Hubbard WC et al. | Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings. | 2006 Sep-Oct | Mol. Genet. Metab. | pmid:16828324 |
| Chen JH et al. | [Measurement and comparison of the spectral transmittance of cerinate porcelain and human enamel]. | 2006 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:17334072 |
| Deon M et al. | The effect of Lorenzo's oil on oxidative stress in X-linked adrenoleukodystrophy. | 2006 | J. Neurol. Sci. | pmid:16750542 |
| Chen YG et al. | Compounds with DNA cleaving activity from Kadsura ananosma. | 2006 | Pharmazie | pmid:17069433 |
| Dhaunsi GS et al. | Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts. | 2005 Jan-Feb | Cell Biochem. Funct. | pmid:15565636 |