| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Diffuse Cerebral Sclerosis of Schilder | D002549 | 8 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Metabolic Diseases | D008659 | 12 associated lipids |
| Adrenocortical Hyperfunction | D000308 | 3 associated lipids |
HEXACOSANOIC ACID
HEXACOSANOIC ACID is a lipid of Fatty Acyls (FA) class. Hexacosanoic acid is associated with abnormalities such as Adrenoleukodystrophy, Adrenal gland hypofunction and Chronic liver disease NOS. The involved functions are known as peroxisome targeting signal-2 binding activity, Oxidation, Demyelination, Mutation and Biosynthetic Pathways. Hexacosanoic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane and Cytoplasm. The associated genes with HEXACOSANOIC ACID are ABCD1 gene, TRAM1 gene, GPX1 gene, SOD1 gene and SOD2 gene. The related lipids are Fatty Acids, Stearic acid, inositolphosphorylceramide, Very long chain fatty acid and Nonesterified Fatty Acids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of HEXACOSANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with HEXACOSANOIC ACID?
HEXACOSANOIC ACID is suspected in Adrenoleukodystrophy, Adrenal gland hypofunction, Chronic liver disease NOS and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with HEXACOSANOIC ACID
PubChem Associated disorders and diseases
What pathways are associated with HEXACOSANOIC ACID
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with HEXACOSANOIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with HEXACOSANOIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with HEXACOSANOIC ACID?
Knock-out
Knock-out are used in the study 'A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.' (Fourcade S et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with HEXACOSANOIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Deng F et al. | New flavonoids and other constituents from Lespedeza cuneata. | J Asian Nat Prod Res | pmid:17943561 | |
| Kaal E et al. | A fast method for the identification of Mycobacterium tuberculosis in sputum and cultures based on thermally assisted hydrolysis and methylation followed by gas chromatography-mass spectrometry. | 2009 | J Chromatogr A | pmid:19631943 |
| Chen JH et al. | Clinical evaluation of 546 tetracycline-stained teeth treated with porcelain laminate veneers. | 2005 | J Dent | pmid:15652162 |
| Bai Y et al. | Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. | 2011 | J Nat Med | pmid:21301979 |
| Meng Z et al. | Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography. | 2007 | J Sep Sci | pmid:17623434 |
| Zarrouk A et al. | Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. | 2015 | J. Alzheimers Dis. | pmid:25428249 |
| Tsuji S et al. | Increased synthesis of hexacosanoic acid (C23:0) by cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and adrenomyeloneuropathy (AMN). | 1981 | J. Biochem. | pmid:7309718 |
| Pillai BK et al. | Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. | 2009 | J. Biol. Chem. | pmid:19801636 |
| Shivashankar S and Sumathi M | Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? | 2015 | J. Biosci. | pmid:25963264 |
| Moser HW | Adrenoleukodystrophy: from bedside to molecular biology. | 1987 | J. Child Neurol. | pmid:3598142 |
| Caruso U et al. | Determination of very-long-chain fatty acids in plasma by a simplified gas chromatographic-mass spectrometric procedure. | 1991 | J. Chromatogr. | pmid:2026688 |
| Wanders RJ et al. | Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. | 1987 | J. Clin. Invest. | pmid:3680527 |
| Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
| Lambert MA et al. | Analysis of mycolic acid cleavage products and cellular fatty acids of Mycobacterium species by capillary gas chromatography. | 1986 | J. Clin. Microbiol. | pmid:3084554 |
| Cappa M et al. | Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible? | 2011 | J. Endocrinol. Invest. | pmid:21399389 |
| Engelen M et al. | Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation. | 2012 | J. Inherit. Metab. Dis. | pmid:22447153 |
| Cappa M et al. | A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers. | 2012 | J. Inherit. Metab. Dis. | pmid:22189598 |
| Watkins PA et al. | Adrenoleukodystrophy: biochemical procedures in diagnosis, prevention and treatment. | 1987 | J. Inherit. Metab. Dis. | pmid:3119941 |
| Govaerts L et al. | Disturbed very long chain (C24-C26) fatty acid pattern in fibroblasts of patients with Zellweger's syndrome. | 1985 | J. Inherit. Metab. Dis. | pmid:3921760 |
| Christensen E et al. | A new peroxisomal beta-oxidation disorder in twin neonates: defective oxidation of both cerotic and pristanic acids. | 1997 | J. Inherit. Metab. Dis. | pmid:9323560 |