Trans-selacholeic acid

Trans-selacholeic acid is a lipid of Fatty Acyls (FA) class. Trans-selacholeic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Metabolic syndrome. The involved functions are known as Inflammation, Insulin Resistance and Synthesis. The associated genes with Trans-selacholeic acid are TNF gene and CCL2 gene. The related lipids are nervonic acid, palmitoleic acid and Sphingolipids.

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Introduction

To understand associated biological information of Trans-selacholeic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Trans-selacholeic acid?

Trans-selacholeic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Trans-selacholeic acid

MeSH term MeSH ID Detail
Adrenoleukodystrophy D000326 29 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with Trans-selacholeic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Trans-selacholeic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Trans-selacholeic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Trans-selacholeic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Trans-selacholeic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Trans-selacholeic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Trans-selacholeic acid

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Authors Title Published Journal PubMed Link
pmid:
Mizushina Y et al. Mode analysis of binding of fatty acids to mammalian DNA polymerases. 2000 Biochim. Biophys. Acta pmid:10903472
Mizushina Y et al. Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. 2000 J. Mol. Biol. pmid:11090281
Kasai N et al. Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase. 2002 J. Biochem. pmid:12417034
Agazzi ME et al. In-house validation of an improved sample extraction and clean-up method for GC determination of isomers of nervonic acid in meat products. 2003 Anal Bioanal Chem pmid:12732919
Bettger WJ et al. Nervonic acid is transferred from the maternal diet to milk and tissues of suckling rat pups. 2003 J. Nutr. Biochem. pmid:12742544
FULCO AJ and MEAD JF The biosynthesis of lignoceric, cerebronic, and nervonic acids. 1961 J. Biol. Chem. pmid:13702539
Weidner E and Findley A Catalase in microsporidian spores before and during discharge. 2003 Biol. Bull. pmid:14583549
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Erkkilä AT et al. Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children. 2005 J Craniofac Surg pmid:16192854
Oda E et al. Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors. 2005 Int Heart J pmid:16394593
Singh B et al. Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn. 2006 Phytother Res pmid:16841368
Murakami S et al. Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta. 2006 Biochem. Biophys. Res. Commun. pmid:16996474
Odabasi E et al. Lipophilic components of different therapeutic mud species. 2007 J Altern Complement Med pmid:18166123
Guo Y et al. Increase in nervonic acid content in transformed yeast and transgenic plants by introduction of a Lunaria annua L. 3-ketoacyl-CoA synthase (KCS) gene. 2009 Plant Mol. Biol. pmid:19082744
Yang J et al. Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. 2009 Biochemistry Mosc. pmid:19747104
Taylor DC et al. Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use. 2009 Plant Biotechnol. J. pmid:19843251
Vluggens A et al. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. 2010 Lab. Invest. pmid:20195242