| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
2,5-hexanedione
2,5-hexanedione is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 1519 references associated with 2,5-hexanedione in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 2,5-hexanedione
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2,5-hexanedione
NCBI Entrez Crosslinks
All references with 2,5-hexanedione
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang Z et al. | 2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway. | 2017 | PLoS ONE | pmid:28654704 |
| Li S et al. | Taurine inhibits 2,5-hexanedione-induced oxidative stress and mitochondria-dependent apoptosis in PC12 cells. | 2017 | Ind Health | pmid:27840369 |
| Dere E et al. | From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure. | 2016 | Toxicol. Sci. | pmid:27466211 |
| Liu S et al. | 2,5-hexanedione induced apoptosis of rat bone marrow mesenchymal stem cells by reactive oxygen species. | 2016 | J Occup Health | pmid:27010086 |
| Ma SX et al. | Impaired expression of neuronal nitric oxide synthase in the gracile nucleus is involved in neuropathic changes in Zucker Diabetic Fatty rats with and without 2,5-hexanedione intoxication. | 2016 | Neurosci. Res. | pmid:26519861 |
| Chen R et al. | 2,5-hexanedione induced apoptosis in mesenchymal stem cells from rat bone marrow via mitochondria-dependent caspase-3 pathway. | 2015 | Ind Health | pmid:25739802 |
| LoPachin RM and Gavin T | Toxic neuropathies: Mechanistic insights based on a chemical perspective. | 2015 | Neurosci. Lett. | pmid:25218479 |
| Gagnaire F and Boucard S | Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione. | 2014 | Neurotoxicology | pmid:24373906 |
| Catlin NR et al. | The stage-specific testicular germ cell apoptotic response to low-dose X-irradiation and 2,5-hexanedione combined exposure. I: Validation of the laser capture microdissection method for qRT-PCR array application. | 2014 | Toxicol Pathol | pmid:24717900 |
| Catlin NR et al. | The stage-specific testicular germ cell apoptotic response to low-dose radiation and 2,5-hexanedione combined exposure. II: qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. | 2014 | Toxicol Pathol | pmid:24670816 |
| Zhu MX et al. | [Formation of pyrrole adducts in 2,5-hexanedione-containing human serum cultured in vitro]. | 2013 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:24053965 |
| Yin H et al. | Correlation between levels of 2, 5-hexanedione and pyrrole adducts in tissues of rats exposure to n-hexane for 5-days. | 2013 | PLoS ONE | pmid:24098756 |
| Zhang W et al. | Apoptosis of rat ovarian granulosa cells by 2,5-hexanedione in vitro and its relevant gene expression. | 2013 | J Appl Toxicol | pmid:22337490 |
| Erdos Z et al. | Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats. | 2013 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:23348767 |
| Pacheco SE et al. | Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting. | 2012 Sep-Oct | J. Androl. | pmid:22240558 |
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| Hanai Y et al. | Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice. | 2012 | Cancer Cell Int. | pmid:22364569 |
| Sun Y et al. | 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways. | 2012 | Arch. Toxicol. | pmid:21901545 |
| Song F et al. | 2,5-hexanedione altered the degradation of low-molecular-weight neurofilament in rat nerve tissues. | 2012 | Food Chem. Toxicol. | pmid:22967723 |
| Pacheco SE et al. | Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat. | 2012 | PLoS ONE | pmid:22952946 |
| Liu HF et al. | [Studying the damages of mouse retina induced by 2,5-hexanedione]. | 2012 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22804983 |
| Campion SN et al. | Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure. | 2012 | Reprod. Toxicol. | pmid:22382377 |
| Cheng X et al. | Exposure to 2,5-hexanedione can induce neural malformations in chick embryos. | 2012 | Neurotoxicology | pmid:22841600 |
| Lee MY et al. | External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals. | 2011 | Saf Health Work | pmid:22953206 |
| Yan BC et al. | The high dosage of earthworm (Eisenia andrei) extract decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus. | 2011 | Anat Cell Biol | pmid:22025974 |
| Viarisio D et al. | E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice. | 2011 | PLoS Pathog. | pmid:21779166 |
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| Koilkonda RD and Guy J | Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside. | 2011 | J Ophthalmol | pmid:21253496 |
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| Wang Q et al. | Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation. | 2011 | Biochem. Pharmacol. | pmid:21219885 |
| Zhao L et al. | The effect of 2,5-hexanedione on myelin protein zero expression, and its mitigation using Ginkgo biloba extract. | 2011 | Biomed. Environ. Sci. | pmid:22108326 |
| Saenko EV et al. | Communication: stabilization of radical anions with weakly bound electron in condensed media: a case study of diacetonyl radical anion. | 2011 | J Chem Phys | pmid:21932869 |
| Kang SK and Kim EA | Occupational diseases in Korea. | 2010 | J. Korean Med. Sci. | pmid:21258589 |
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| Rose G et al. | Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. | 2010 | PLoS ONE | pmid:20976236 |
| Yu D et al. | Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C. | 2010 | PLoS ONE | pmid:20976138 |
| Santoro A et al. | Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. | 2010 | PLoS ONE | pmid:20700462 |
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| Bandyopadhyay D et al. | Remarkable iodine-catalyzed synthesis of novel pyrrole-bearing N-polyaromatic beta-lactams. | 2010 | Molecules | pmid:20335963 |
| Pacenti M et al. | New automated and high-throughput quantitative analysis of urinary ketones by multifiber exchange-solid phase microextraction coupled to fast gas chromatography/negative chemical-electron ionization/mass spectrometry. | 2010 | J Autom Methods Manag Chem | pmid:20628512 |
| Liu Q et al. | The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats. | 2010 | Hum Exp Toxicol | pmid:20051453 |
| Liu QJ et al. | [The effect of 2,5-hexanedione on nerve growth factor in sciatic nerve of rats and VSC4.1 cell]. | 2010 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:20388358 |
| Müller M et al. | Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae. | 2010 | Org. Biomol. Chem. | pmid:20237665 |
| Campion SN et al. | Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis. | 2010 | Toxicol. Sci. | pmid:20616204 |
| Yamasaki H et al. | Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. | 2010 | Toxicol. Sci. | pmid:20616207 |
| Campion SN et al. | Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways. | 2010 | Toxicol. Sci. | pmid:20616210 |
| Liu Q et al. | [Effect of 2,5-hexanedione on myelin protein zero in sciatic nerve and its antibody in serum of rats at different time points]. | 2010 | Wei Sheng Yan Jiu | pmid:20568451 |
| Zhang L et al. | Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons. | 2010 | Toxicol. Sci. | pmid:20554699 |
| Katzberg M et al. | Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example. | 2010 | Int J Mol Sci | pmid:20480039 |
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| Santos AC et al. | 1,5-Bis(2,5-dimethyl-1H-pyrrol-1-yl)naphthalene. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578234 |
| Tshala-Katumbay D et al. | Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane. | 2009 | Toxicol. Sci. | pmid:19033394 |
| Fang F et al. | Workplace exposures and the risk of amyotrophic lateral sclerosis. | 2009 | Environ. Health Perspect. | pmid:19750102 |
| DeCaprio AP et al. | Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat. | 2009 | J. Toxicol. Environ. Health Part A | pmid:19557614 |
| Sari-Minodier I et al. | The effect of workload on biological monitoring of occupational exposure to toluene and n-Hexane: contribution of physiologically based toxicokinetic modeling. | 2009 | J Occup Environ Hyg | pmid:19384711 |
| Kim MS et al. | Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis. | 2009 | Toxicology | pmid:19464574 |
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| Gao XC et al. | [Effects of garlic oil on 2, 5-HD induced lipid peroxidation damage in rat nerve tissues]. | 2008 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:19467181 |
| Machielsen R et al. | Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures. | 2008 | Extremophiles | pmid:18452026 |
| Coleman MD et al. | A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y. | 2008 | Basic Clin. Pharmacol. Toxicol. | pmid:17973901 |
| Song F et al. | The reversibility of neurofilaments decline induced by 2,5-hexanedione in rat nerve tissues. | 2008 | Biochem. Pharmacol. | pmid:18001694 |
| Wang QS et al. | Changes of cytoskeletal proteins in nerve tissues and serum of rats treated with 2,5-hexanedione. | 2008 | Toxicology | pmid:18177991 |
| Wang QS et al. | Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy. | 2008 | Toxicology | pmid:18423835 |
| Qian Y and Zeng F | Re-establishment of spermatogenesis by diethylstilbestrol after 2,5-hexanedione-induced irreversible testicular atrophy in rats. | 2008 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:18480992 |
| Wang QS et al. | 2,5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18582483 |
| Bryant BH et al. | Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. | 2008 | Toxicol Pathol | pmid:18467684 |
| Jiang YG et al. | Resveratrol reestablishes spermatogenesis after testicular injury in rats caused by 2, 5-hexanedione. | 2008 | Chin. Med. J. | pmid:18710639 |
| Prieto-Castelló MJ et al. | Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane. | 2007 | Toxicology | pmid:17125898 |
| Elci OC et al. | Working conditions and related neuropsychiatric problems among shoemakers in Turkey: Do child workers differ from others? | 2007 | Indian J Occup Environ Med | pmid:21957366 |
| Song F et al. | Time-dependent alteration of cytoskeletal proteins in cerebral cortex of rat during 2,5-hexanedione-induced neuropathy. | 2007 | Neurochem. Res. | pmid:17447142 |
| Moffit JS et al. | Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. | 2007 | Toxicol Pathol | pmid:17763286 |
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| Carelli V et al. | Grand rounds: could occupational exposure to n-hexane and other solvents precipitate visual failure in leber hereditary optic neuropathy? | 2007 | Environ. Health Perspect. | pmid:17366829 |
| Pei W et al. | Two new reactive targets of 2,5-hexanedione in vitro - beta-alanine and glycine. | 2007 | Amino Acids | pmid:16733615 |
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| Yamamoto T et al. | Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants. | 2005 | J Toxicol Sci | pmid:15928459 |
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