| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
2,5-hexanedione
2,5-hexanedione is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 1519 references associated with 2,5-hexanedione in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 2,5-hexanedione
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2,5-hexanedione
NCBI Entrez Crosslinks
All references with 2,5-hexanedione
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| LoPachin RM and DeCaprio AP | gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15289087 |
| LoPachin RM et al. | 2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15207649 |
| Chapin RE | Nature is complex: our orchestra seats at the most wonderful show on earth. | 2004 | Toxicol. Sci. | pmid:15237525 |
| Markelewicz RJ et al. | 2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules. | 2004 | Toxicol. Sci. | pmid:15141104 |
| Pereira ME et al. | 2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro. | 2004 | Toxicol. Lett. | pmid:14687764 |
| Strassnig S et al. | Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15556528 |
| Amarnath V et al. | Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. | 2004 | Chem. Res. Toxicol. | pmid:15025512 |
| Prieto MJ et al. | Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry. | 2003 | Toxicol. Lett. | pmid:14580896 |
| Baldasseroni A et al. | Occupational exposure to n-hexane in Italy--analysis of a registry of biological monitoring. | 2003 | Int Arch Occup Environ Health | pmid:12768281 |
| Canesi M et al. | Poor metabolization of n-hexane in Parkinson's disease. | 2003 | J. Neurol. | pmid:12736734 |
| Nowak I and Robins MJ | Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety. | 2003 | Org. Lett. | pmid:12943423 |
| Hernandez-Viadel M et al. | Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo. | 2003 | Neurochem. Int. | pmid:12590934 |
| Boekelheide K et al. | 2,5-hexanedione-induced testicular injury. | 2003 | Annu. Rev. Pharmacol. Toxicol. | pmid:12471174 |
| LoPachin RM et al. | gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14613714 |
| Burgaz S et al. | Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde. | 2002 Mar-Apr | Biomarkers | pmid:12101634 |
| Mayan O et al. | Urinary 2,5 hexanedione as a biomarker of n-hexane exposure. | 2002 Jul-Aug | Biomarkers | pmid:12171757 |
| Pastore C et al. | Partial conduction blocks in N-hexane neuropathy. | 2002 | Muscle Nerve | pmid:12115958 |
| Shibata E et al. | Changes in n-hexane toxicokinetics in short-term single exposure due to co-exposure to methyl ethyl ketone in volunteers. | 2002 | Int Arch Occup Environ Health | pmid:12070636 |
| dos Santos CR et al. | Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12376131 |
| Carney R et al. | Early spatial memory deficit induced by 2,5-hexanedione in the rat. | 2002 | Toxicol. Lett. | pmid:11869822 |
| LoPachin RM et al. | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione. | 2002 | Neurotoxicology | pmid:12164553 |
| Yokoyama K et al. | Computerized posturography with sway frequency analysis: application in occupational and environmental health. | 2002 | Ind Health | pmid:11926510 |
| Mateus ML et al. | Evidence of zinc protection against 2,5-hexanedione neurotoxicity: correlation of neurobehavioral testing with biomarkers of excretion. | 2002 | Neurotoxicology | pmid:12520764 |
| Hernandez-Viadel ML et al. | Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione. | 2002 | Toxicol Ind Health | pmid:15068133 |
| Kato M et al. | Overview of studies on rat sperm motion analysis using a Hamilton-Thorne Sperm Analyzer--collaborative working study. | 2001 | J Toxicol Sci | pmid:11871125 |
| Xu G et al. | Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles. | 2001 | Chem. Res. Toxicol. | pmid:11258975 |
| Stone JD et al. | Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration. | 2001 | J. Neurosci. | pmid:11264303 |
| Boekelheide K and Schoenfeld HA | Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury. | 2001 | Adv. Exp. Med. Biol. | pmid:11764975 |
| Mateus ML et al. | Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure. | 2001 | Toxicol. Lett. | pmid:11275420 |
| Opanashuk LA et al. | Gamma-diketone peripheral neuropathy III. Neurofilament gene expression. | 2001 | Neurotoxicology | pmid:11405253 |
| Mateus ML et al. | Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride. | 2000 May-Jun | J Appl Toxicol | pmid:10797474 |
| Horimoto M et al. | Rat epididymal sperm motion changes induced by ethylene glycol monoethyl ether, sulfasalazine, and 2,5-hexandione. | 2000 Jan-Feb | Reprod. Toxicol. | pmid:10689203 |
| LoPachin RM | Redefining toxic distal axonopathies. | 2000 | Toxicol. Lett. | pmid:10720709 |
| Heijink E et al. | Effects of 2,5-hexanedione on calpain-mediated degradation of human neurofilaments in vitro. | 2000 | Chem. Biol. Interact. | pmid:11137063 |
| Johnson KJ et al. | Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. | 2000 | Endocrinology | pmid:10650949 |
| Lehning EJ et al. | gamma-diketone peripheral neuropathy. I. Quality morphometric analyses of axonal atrophy and swelling. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10828208 |
| Chiu FC et al. | gamma-diketone peripheral neuropathy. II. Neurofilament subunit content. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10828209 |
| Yokoyama K et al. | Decrease of glucose utilization rate in the spinal cord of experimental 2,5-hexanedione poisoning rats: application of microdetermination technique. | 2000 | Ind Health | pmid:10812841 |
| Boekelheide K et al. | Role of Sertoli cells in injury-associated testicular germ cell apoptosis. | 2000 | Proc. Soc. Exp. Biol. Med. | pmid:11044252 |
| Podrez EA et al. | Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein. | 2000 | J. Lipid Res. | pmid:10974053 |
| Stone JD et al. | Neurofilaments are non-essential elements of toxicant-induced reductions in fast axonal transport: pulse labeling in CNS neurons. | 2000 | Neurotoxicology | pmid:11022855 |
| Schmuck G et al. | Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity. | 2000 | In Vitr Mol Toxicol | pmid:10900406 |
| Hirai T et al. | Neurotoxic effects of 2,5-hexanedione on normal and neurofilament-deficient quail. | 1999 May-Jun | Toxicol Pathol | pmid:10356712 |
| Xu G et al. | Rapid cross-linking of proteins by 4-ketoaldehydes and 4-hydroxy-2-alkenals does not arise from the lysine-derived monoalkylpyrroles. | 1999 | Chem. Res. Toxicol. | pmid:10490508 |
| Schulte MD et al. | Volumes of aqueous alcohols, ethers, and ketones to T = 523 K and p = 28 MPa. | 1999 | J Chem Thermodyn | pmid:11543305 |
| Stone JD et al. | Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: video-enhanced differential interference microscopy in peripheral nervous system axons. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10558923 |
| Ishihara A et al. | [Effect of 2,5-hexanedione on myosin heavy chain isoform content in perineal muscles of the rats]. | 1999 | Nihon Seirigaku Zasshi | pmid:10668552 |
| Lee J et al. | The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. | 1999 | Endocrinology | pmid:9927315 |
| Blanchard KT et al. | Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression. | 1998 | Endocrinology | pmid:9421420 |
| Bäckström B et al. | 2,5-Hexanedione concentrations and morphological changes within the eye of albino rat. | 1998 | Arch. Toxicol. | pmid:9806432 |
| Bavazzano P et al. | Determination of urinary 2,5-hexanedione in the general Italian population. | 1998 | Int Arch Occup Environ Health | pmid:9638486 |
| Zhao W et al. | Relationship between 2,5-hexanedione concentrations in nerve, serum, and urine alone or under co-treatment with different doses of methyl ethyl ketone, acetone, and toluene. | 1998 | Neurochem. Res. | pmid:9572672 |
| Mortensen B et al. | Metabolic interaction of n-hexane and methyl ethyl ketone in vitro in a head space rat liver S9 vial equilibration system. | 1998 | Pharmacol. Toxicol. | pmid:9498234 |
| Andreoli R et al. | Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 1. 2,5-hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization. | 1998 | Rapid Commun. Mass Spectrom. | pmid:9773526 |
| Hartley CL et al. | Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies. | 1997 | Neuropathol. Appl. Neurobiol. | pmid:9364461 |
| Mortensen B et al. | Comparison and in vivo relevance of two different in vitro head space metabolic systems: liver S9 and liver slices. | 1997 | Pharmacol. Toxicol. | pmid:9258983 |
| Graham DG | Protein crosslinking correlates with axonal atrophy, swelling and degeneration in gamma-diketone neuropathy: commentary on forum position paper. | 1997 | Neurotoxicology | pmid:9215983 |
| Sayre LM and Gambetti P | Mechanistic importance of axonal atrophy and swelling in gamma-diketone axonopathy: commentary on forum position paper. | 1997 | Neurotoxicology | pmid:9215984 |
| Jackson JR et al. | Changes in immunoglobulin concentrations and urinary 2,5-hexanedione concentrations. | 1997 | Hum Exp Toxicol | pmid:9192211 |
| Ogata M et al. | Large-scale biological monitoring in Japan. | 1997 | Sci. Total Environ. | pmid:9200864 |
| DeCaprio AP et al. | Regioselective binding of 2,5-hexanedione to high-molecular-weight rat neurofilament proteins in vitro. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9221839 |
| Cohen SD et al. | Selective protein covalent binding and target organ toxicity. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9073586 |
| Misumi J et al. | Different administration schedules of the same dose of 2,5-hexanedione influence the development of neuropathy and the toxicokinetics. | 1997 | Neurochem. Res. | pmid:9021758 |
| Zhu M et al. | Characterization of glutathione conjugates of pyrrolylated amino acids and peptides by liquid chromatography-mass spectrometry and tandem mass spectrometry with electrospray ionization. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9061455 |
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| Allard EK et al. | Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2,5-hexanedione-induced testicular atrophy in rats. | 1996 | Biol. Reprod. | pmid:8793074 |
| Blanchard KT et al. | Fate of germ cells in 2,5-hexanedione-induced testicular injury. I. Apoptosis is the mechanism of germ cell death. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8661338 |
| Oishi Y et al. | The effects of 2,5-hexanedione and acrylamide on myosin heavy chain isoforms of slow and fast skeletal muscles of the rat. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8685898 |
| Gupta RP and Abou-Donia MB | Alterations in the neutral proteinase activities of central and peripheral nervous systems of acrylamide-, carbon disulfide-, or 2,5-hexanedione-treated rats. | 1996 | Mol. Chem. Neuropathol. | pmid:8887940 |
| Passarin MG et al. | Cytoskeletal changes in cultured human fibroblasts following exposure to 2,5-hexanedione. | 1996 | Neuropathol. Appl. Neurobiol. | pmid:8866784 |
| Ogawa Y et al. | 2,5-Hexanedione induced apoptosis in cultured mouse DRG neurons. | 1996 | Int Arch Occup Environ Health | pmid:8891791 |
| Yan B et al. | Solid-state 13C-NMR spectroscopy of adduction products of 2,5-hexanedione with ribonuclease, albumin, and rat neurofilament protein. | 1996 | Chem. Biol. Interact. | pmid:8950225 |
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| Rosiepen G et al. | The duration of the cycle of the seminiferous epithelium is altered by administration of 2,5-hexanedione in the adult Sprague-Dawley rat. | 1995 Mar-Apr | J. Androl. | pmid:7559142 |
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| Hall ES et al. | 2,5-Hexanedione exposure alters microtubule motor distribution in adult rat testis. | 1995 | Fundam Appl Toxicol | pmid:7737429 |
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