| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Anorexia | D000855 | 8 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
| Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. | 1982 Mar-Apr | Arteriosclerosis | pmid:7039581 | |
| Lucchi L et al. | Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients. | 2005 | Artif Organs | pmid:15854218 |
| Canudas N et al. | Photosensitizing properties of Actarit, an antirheumatic drug. | 2008 | Arzneimittelforschung | pmid:18540480 |
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| Liu Q et al. | Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. | 2017 Mar-Apr | Asian J. Androl. | pmid:26763547 |
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| Tilvis RS et al. | Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. | 1987 | Atherosclerosis | pmid:3619988 |
| Sneddon AA et al. | Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. | 2003 | Atherosclerosis | pmid:14642406 |
| Kromhout D et al. | Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol. | 1987 | Atherosclerosis | pmid:3632757 |
| Berlin E et al. | Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men. | 1987 | Atherosclerosis | pmid:3632760 |
| Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
| Huang YS et al. | Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). | 1982 | Atherosclerosis | pmid:6279122 |
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| Allman-Farinelli MA et al. | Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. | 1999 | Atherosclerosis | pmid:9920517 |
| HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
| Ramasamy S et al. | Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. | 1996 | Atherosclerosis | pmid:8645361 |
| Hornstra G and Kester AD | Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. | 1997 | Atherosclerosis | pmid:9180241 |
| de Waart FG et al. | Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. | 1997 | Atherosclerosis | pmid:9298686 |
| van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
| Wilson TA et al. | Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. | 1998 | Atherosclerosis | pmid:9733225 |
| Jones PJ et al. | High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. | 2015 | Atherosclerosis | pmid:25528432 |
| Porkkala-Sarataho E et al. | Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. | 1996 | Atherosclerosis | pmid:8800496 |
| Válek J et al. | Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. | 1985 | Atherosclerosis | pmid:3994777 |
| Waddington EI et al. | Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. | 2003 | Atherosclerosis | pmid:12618275 |
| Weldon S et al. | Conjugated linoleic acid and atherosclerosis: no effect on molecular markers of cholesterol homeostasis in THP-1 macrophages. | 2004 | Atherosclerosis | pmid:15136056 |
| Naqvi AZ et al. | Dietary fatty acids and peripheral artery disease in adults. | 2012 | Atherosclerosis | pmid:22552117 |
| van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
| Ohrvall M et al. | Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. | 1994 | Atherosclerosis | pmid:7980703 |
| Lee KN et al. | Conjugated linoleic acid and atherosclerosis in rabbits. | 1994 | Atherosclerosis | pmid:7980704 |
| Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
| Shiina T et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. | 1993 | Atherosclerosis | pmid:8141854 |
| Liu SX et al. | Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. | 1998 | Atherosclerosis | pmid:9544730 |
| Fuhrman B et al. | Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. | 1994 | Atherosclerosis | pmid:7840815 |
| Ramasamy S et al. | Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. | 1993 | Atherosclerosis | pmid:8292102 |
| Uehara Y et al. | Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. | 2007 | Atherosclerosis | pmid:16730733 |
| Lux CA et al. | Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. | 2009 | Atherosclerosis | pmid:19423111 |
| Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
| Hannah JS et al. | High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. | 1997 | Atherosclerosis | pmid:9247355 |
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| Singh SP et al. | Absence of effect of prostaglandins on cholesteryl ester metabolism of 3T3 mouse fibroblasts grown in tissue culture. | 1982 | Atherosclerosis | pmid:6952877 |
| Koo SI and Ramlet JS | Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol. | 1984 | Atherosclerosis | pmid:6712766 |
| Tavendale R et al. | Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. | 1992 | Atherosclerosis | pmid:1632870 |
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