| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Strauss JS et al. | The effect of 13-cis-retinoic acid on sebaceous glands. | 1987 | Arch Dermatol | pmid:2960273 |
| Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
| Wertz PW et al. | Essential fatty acids and epidermal integrity. | 1987 | Arch Dermatol | pmid:3310912 |
| Khodadadi I et al. | Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. | 2008 | Arch Iran Med | pmid:18154422 |
| Muakkassa FF et al. | Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. | 1991 | Arch Surg | pmid:1992995 |
| DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
| Rustin P et al. | Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. | 1983 | Arch. Biochem. Biophys. | pmid:6414377 |
| Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
| Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
| Hamberg M and Hamberg G | Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). | 1990 | Arch. Biochem. Biophys. | pmid:2275553 |
| Glasgow WC and Eling TE | Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8203891 |
| Guha SN et al. | Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. | 1993 | Arch. Biochem. Biophys. | pmid:8342946 |
| Sutherland MW and Gebicki JM | A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles. | 1982 | Arch. Biochem. Biophys. | pmid:6282219 |
| CENTURY B and HORWITT MK | ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS. | 1964 | Arch. Biochem. Biophys. | pmid:14161009 |
| BRESSLER R and FRIEDBERG SJ | SUBSTRATE SPECIFICITY OF THE FATTY ACID OXIDASE IN THE HEART. | 1964 | Arch. Biochem. Biophys. | pmid:14161011 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
| Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
| PORTMAN OW and SUGANO M | THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. | 1963 | Arch. Biochem. Biophys. | pmid:14072510 |
| Winterbourn CC et al. | Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. | 1992 | Arch. Biochem. Biophys. | pmid:1321589 |
| MATSUSHITA S et al. | CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS. | 1963 | Arch. Biochem. Biophys. | pmid:14072524 |
| Kearns EV et al. | The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). | 1991 | Arch. Biochem. Biophys. | pmid:1989527 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
| Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
| Gerwick WH et al. | Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. | 1991 | Arch. Biochem. Biophys. | pmid:1929410 |
| Draper AJ and Hammock BD | Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10729206 |
| Loftin CD and Eling TE | Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. | 1996 | Arch. Biochem. Biophys. | pmid:8660674 |
| Fukuzawa K et al. | Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. | 1991 | Arch. Biochem. Biophys. | pmid:1656881 |
| Hamberg M et al. | Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. | 1994 | Arch. Biochem. Biophys. | pmid:8117115 |
| VIOQUE E and HOLMAN RT | Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. | 1962 | Arch. Biochem. Biophys. | pmid:13997422 |
| Ashida H et al. | Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:3688880 |
| Hennig B et al. | Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. | 1986 | Arch. Biochem. Biophys. | pmid:3729421 |
| Hörnsten L et al. | Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8806734 |
| PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
| Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
| Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
| MEDES G et al. | Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. | 1951 | Arch. Biochem. Biophys. | pmid:14847665 |
| Kulkarni AP and Sajan M | Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. | 1999 | Arch. Biochem. Biophys. | pmid:10545208 |
| Behrends W et al. | The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. | 1988 | Arch. Biochem. Biophys. | pmid:3369861 |
| Duthie GG et al. | Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. | 1992 | Arch. Biochem. Biophys. | pmid:1632646 |
| PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
| TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
| KHAN NA | Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. | 1953 | Arch. Biochem. Biophys. | pmid:13058378 |
| TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
| Laidler P et al. | Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? | 2007 | Arch. Biochem. Biophys. | pmid:17466258 |
| Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
| Hamberg M | Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. | 1998 | Arch. Biochem. Biophys. | pmid:9448728 |
| Nemecz G et al. | Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. | 1991 | Arch. Biochem. Biophys. | pmid:1897956 |
| SIDDIQI AM and TAPPEL AL | Catalysis of linoleate oxidation by pea lipoxidase. | 1956 | Arch. Biochem. Biophys. | pmid:13283592 |
| KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
| Fukuzawa K et al. | Site-specific induction of lipid peroxidation by iron in charged micelles. | 1988 | Arch. Biochem. Biophys. | pmid:2829725 |